Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents

Several studies recommended that plants are potential source of bioactive compounds. Phyllanthus niruri is one of plants, which used as a traditional medicine due its richness of phytomedicine metabolites. Identifying the appropriate solvent of extracting these bioactive components from Phyllanthus...

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Main Authors:	Mediani, Ahmed, Abas, Faridah, Khatib, Alfi, Ismail , Intan Safinar, Shaari, Khozirah, Ismail, Amin, Lajis, Nurdin Hj
Format:	Article
Language:	English
Published:	2013
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/31373/ http://irep.iium.edu.my/31373/ http://irep.iium.edu.my/31373/1/254TOPROCJ.htm

id	iium-31373
recordtype	eprints
spelling	iium-313732013-09-27T02:41:32Z http://irep.iium.edu.my/31373/ Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents Mediani, Ahmed Abas, Faridah Khatib, Alfi Ismail , Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nurdin Hj QD Chemistry Several studies recommended that plants are potential source of bioactive compounds. Phyllanthus niruri is one of plants, which used as a traditional medicine due its richness of phytomedicine metabolites. Identifying the appropriate solvent of extracting these bioactive components from Phyllanthus niruri is thus a crucial step to increase its significance and competence. The influence of drying on its quality and productivity was also evaluated. Three extracting solvents (ethanol, methanol, water) with different ratio were assessed for their effects on biological activities of P. niruri which are dried with three drying methods (air, oven and freeze). The antioxidant activity was evaluated using free radical scavenging ability (DPPH), FRAP and total phenolic content (TPC) assays and antidiabetic by a-glucosidase assay. The selectivity of solvents was also evaluated in terms of the phytochemical compounds present and their concentrations based on quantifying them by LCMS. As function to solvent and drying methods, freeze dried, P. niruri extracted with 80% methanol and water exhibited valuable and higher antioxidant and antidiabetic activities. Principal component analysis (PCA) revealed the relationship among the potential antioxidant activity, total phenolic, a-glucosidase and metabolites levels of the extracts. The present study proposes that P. niruri can be a prominent and constructive medicinal plant. 2013-03-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/31373/1/254TOPROCJ.htm Mediani, Ahmed and Abas, Faridah and Khatib, Alfi and Ismail , Intan Safinar and Shaari, Khozirah and Ismail, Amin and Lajis, Nurdin Hj (2013) Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents. The Open Conference Proceedings Journal. ISSN 2210-2892 http://www.benthamscience.com/open/toprocj/articles/V004/254TOPROCJ.htm
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Mediani, Ahmed Abas, Faridah Khatib, Alfi Ismail , Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nurdin Hj Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents
description	Several studies recommended that plants are potential source of bioactive compounds. Phyllanthus niruri is one of plants, which used as a traditional medicine due its richness of phytomedicine metabolites. Identifying the appropriate solvent of extracting these bioactive components from Phyllanthus niruri is thus a crucial step to increase its significance and competence. The influence of drying on its quality and productivity was also evaluated. Three extracting solvents (ethanol, methanol, water) with different ratio were assessed for their effects on biological activities of P. niruri which are dried with three drying methods (air, oven and freeze). The antioxidant activity was evaluated using free radical scavenging ability (DPPH), FRAP and total phenolic content (TPC) assays and antidiabetic by a-glucosidase assay. The selectivity of solvents was also evaluated in terms of the phytochemical compounds present and their concentrations based on quantifying them by LCMS. As function to solvent and drying methods, freeze dried, P. niruri extracted with 80% methanol and water exhibited valuable and higher antioxidant and antidiabetic activities. Principal component analysis (PCA) revealed the relationship among the potential antioxidant activity, total phenolic, a-glucosidase and metabolites levels of the extracts. The present study proposes that P. niruri can be a prominent and constructive medicinal plant.
format	Article
author	Mediani, Ahmed Abas, Faridah Khatib, Alfi Ismail , Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nurdin Hj
author_facet	Mediani, Ahmed Abas, Faridah Khatib, Alfi Ismail , Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nurdin Hj
author_sort	Mediani, Ahmed
title	Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents
title_short	Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents
title_full	Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents
title_fullStr	Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents
title_full_unstemmed	Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents
title_sort	antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents
publishDate	2013
url	http://irep.iium.edu.my/31373/ http://irep.iium.edu.my/31373/ http://irep.iium.edu.my/31373/1/254TOPROCJ.htm
first_indexed	2023-09-18T20:45:36Z
last_indexed	2023-09-18T20:45:36Z
_version_	1777409653307604992

Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents

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