Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination

Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover events cluster, differ markedly in their genomic location between the species. We report that a 13-base pair sequence motif previously associated with the activity of 40% of human hotspots does not fu...

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Main Authors:	Myers, Simon, Bowden, Rory, Tumian, Afidalina, Bontrop, Ronald E, Freeman, Colin, MacFie, Tammie S., McVean, Gil, Donnelly, Peter
Format:	Article
Language:	English
Published:	American Association for the Advancement of Science 2010
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/31421/ http://irep.iium.edu.my/31421/ http://irep.iium.edu.my/31421/ http://irep.iium.edu.my/31421/1/myers2010.pdf

id	iium-31421
recordtype	eprints
spelling	iium-314212013-08-19T03:42:41Z http://irep.iium.edu.my/31421/ Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination Myers, Simon Bowden, Rory Tumian, Afidalina Bontrop, Ronald E Freeman, Colin MacFie, Tammie S. McVean, Gil Donnelly, Peter Q Science (General) Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover events cluster, differ markedly in their genomic location between the species. We report that a 13-base pair sequence motif previously associated with the activity of 40% of human hotspots does not function in chimpanzees and is being removed by self-destructive drive in the human lineage. Multiple lines of evidence suggest that the rapidly evolving zinc-finger protein PRDM9 binds to this motif and that sequence changes in the protein may be responsible for hotspot differences between species. The involvement of PRDM9, which causes histone H3 lysine 4 trimethylation, implies that there is a common mechanism for recombination hotspots in eukaryotes but raises questions about what forces have driven such rapid change. American Association for the Advancement of Science 2010-02-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/31421/1/myers2010.pdf Myers, Simon and Bowden, Rory and Tumian, Afidalina and Bontrop, Ronald E and Freeman, Colin and MacFie, Tammie S. and McVean, Gil and Donnelly, Peter (2010) Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science, 327 (5967). pp. 876-879. ISSN 0036-8075 http://www.sciencemag.org/content/327/5967/876.abstract 10.1126/science.1182363
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Myers, Simon Bowden, Rory Tumian, Afidalina Bontrop, Ronald E Freeman, Colin MacFie, Tammie S. McVean, Gil Donnelly, Peter Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination
description	Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover events cluster, differ markedly in their genomic location between the species. We report that a 13-base pair sequence motif previously associated with the activity of 40% of human hotspots does not function in chimpanzees and is being removed by self-destructive drive in the human lineage. Multiple lines of evidence suggest that the rapidly evolving zinc-finger protein PRDM9 binds to this motif and that sequence changes in the protein may be responsible for hotspot differences between species. The involvement of PRDM9, which causes histone H3 lysine 4 trimethylation, implies that there is a common mechanism for recombination hotspots in eukaryotes but raises questions about what forces have driven such rapid change.
format	Article
author	Myers, Simon Bowden, Rory Tumian, Afidalina Bontrop, Ronald E Freeman, Colin MacFie, Tammie S. McVean, Gil Donnelly, Peter
author_facet	Myers, Simon Bowden, Rory Tumian, Afidalina Bontrop, Ronald E Freeman, Colin MacFie, Tammie S. McVean, Gil Donnelly, Peter
author_sort	Myers, Simon
title	Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination
title_short	Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination
title_full	Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination
title_fullStr	Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination
title_full_unstemmed	Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination
title_sort	drive against hotspot motifs in primates implicates the prdm9 gene in meiotic recombination
publisher	American Association for the Advancement of Science
publishDate	2010
url	http://irep.iium.edu.my/31421/ http://irep.iium.edu.my/31421/ http://irep.iium.edu.my/31421/ http://irep.iium.edu.my/31421/1/myers2010.pdf
first_indexed	2023-09-18T20:45:37Z
last_indexed	2023-09-18T20:45:37Z
_version_	1777409655024123904

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination

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