A Study of Paraoxonase (PON-1) Activity and Concentration in Coronary Artery Disease Patients in Kuantan, Pahang

Introduction: Paraoxonase 1 (PON1) is a high density lipoprotein (HDL) associated enzyme that is known to inhibit oxidative modification of low density lipoprotein (LDL), thus implicated in the pathogenesis of atherosclerosis and coronary artery disease (CAD). It has been suggested that the varia...

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Main Authors:	Abdullah, Nor Zamzila, Muhammad Musa, Nur Ashikin, A.Talib, Norlelawati, Nik Ahmad, Nik Nur Fatnoon
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/32176/ http://irep.iium.edu.my/32176/4/Nor_Zamzila.pdf

id	iium-32176
recordtype	eprints
spelling	iium-321762013-11-22T07:35:31Z http://irep.iium.edu.my/32176/ A Study of Paraoxonase (PON-1) Activity and Concentration in Coronary Artery Disease Patients in Kuantan, Pahang Abdullah, Nor Zamzila Muhammad Musa, Nur Ashikin A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon RB Pathology Introduction: Paraoxonase 1 (PON1) is a high density lipoprotein (HDL) associated enzyme that is known to inhibit oxidative modification of low density lipoprotein (LDL), thus implicated in the pathogenesis of atherosclerosis and coronary artery disease (CAD). It has been suggested that the variability in this enzyme activity is attributed to polymorphism in PON-1 gene. Nevertheless, even within the same genotype, PON-1 activity and concentration has been shown to vary widely between the different individuals. Therefore, recent studies in various populations have emphasized on the importance of measuring the PON1 activity and concentration in assessing the risk of CAD. The data of such study is however scarce in Malaysia. Objective: The aim of this study was to compare the PON-1 activities and concentration between the healthy controls and CAD patients. Methods: A comparative cross sectional study was carried out on 187 CAD patients in Tengku Ampuan Afzan Hospital, Kuantan and 188 healthy controls. Serum samples were analyzed for PON-1 activities towards paraoxon and phenylacetate as well as for HDLcholesterol. PON1 concentration was expressed as PON1 activity per mmol of HDL. Results: Serum PON-1 activities as well as concentration were found to be lower in CAD patients than in the healthy controls but the results were not significant (p > 0.05). Conclusion: Our finding suggested that PON1 activities and concentration were similar between healthy control and CAD patients in Kuantan, Pahang. A multicentre study may be required to confirm our findings in Malaysian population. 2013 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/32176/4/Nor_Zamzila.pdf Abdullah, Nor Zamzila and Muhammad Musa, Nur Ashikin and A.Talib, Norlelawati and Nik Ahmad, Nik Nur Fatnoon (2013) A Study of Paraoxonase (PON-1) Activity and Concentration in Coronary Artery Disease Patients in Kuantan, Pahang. In: International Conference on Medical and Health Sciences, 22nd - 24th May 2013, Renaissance Hotel, Kota Bahru, Kelantan.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Abdullah, Nor Zamzila Muhammad Musa, Nur Ashikin A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon A Study of Paraoxonase (PON-1) Activity and Concentration in Coronary Artery Disease Patients in Kuantan, Pahang
description	Introduction: Paraoxonase 1 (PON1) is a high density lipoprotein (HDL) associated enzyme that is known to inhibit oxidative modification of low density lipoprotein (LDL), thus implicated in the pathogenesis of atherosclerosis and coronary artery disease (CAD). It has been suggested that the variability in this enzyme activity is attributed to polymorphism in PON-1 gene. Nevertheless, even within the same genotype, PON-1 activity and concentration has been shown to vary widely between the different individuals. Therefore, recent studies in various populations have emphasized on the importance of measuring the PON1 activity and concentration in assessing the risk of CAD. The data of such study is however scarce in Malaysia. Objective: The aim of this study was to compare the PON-1 activities and concentration between the healthy controls and CAD patients. Methods: A comparative cross sectional study was carried out on 187 CAD patients in Tengku Ampuan Afzan Hospital, Kuantan and 188 healthy controls. Serum samples were analyzed for PON-1 activities towards paraoxon and phenylacetate as well as for HDLcholesterol. PON1 concentration was expressed as PON1 activity per mmol of HDL. Results: Serum PON-1 activities as well as concentration were found to be lower in CAD patients than in the healthy controls but the results were not significant (p > 0.05). Conclusion: Our finding suggested that PON1 activities and concentration were similar between healthy control and CAD patients in Kuantan, Pahang. A multicentre study may be required to confirm our findings in Malaysian population.
format	Conference or Workshop Item
author	Abdullah, Nor Zamzila Muhammad Musa, Nur Ashikin A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon
author_facet	Abdullah, Nor Zamzila Muhammad Musa, Nur Ashikin A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon
author_sort	Abdullah, Nor Zamzila
title	A Study of Paraoxonase (PON-1) Activity and Concentration in Coronary Artery Disease Patients in Kuantan, Pahang
title_short	A Study of Paraoxonase (PON-1) Activity and Concentration in Coronary Artery Disease Patients in Kuantan, Pahang
title_full	A Study of Paraoxonase (PON-1) Activity and Concentration in Coronary Artery Disease Patients in Kuantan, Pahang
title_fullStr	A Study of Paraoxonase (PON-1) Activity and Concentration in Coronary Artery Disease Patients in Kuantan, Pahang
title_full_unstemmed	A Study of Paraoxonase (PON-1) Activity and Concentration in Coronary Artery Disease Patients in Kuantan, Pahang
title_sort	study of paraoxonase (pon-1) activity and concentration in coronary artery disease patients in kuantan, pahang
publishDate	2013
url	http://irep.iium.edu.my/32176/ http://irep.iium.edu.my/32176/4/Nor_Zamzila.pdf
first_indexed	2023-09-18T20:46:26Z
last_indexed	2023-09-18T20:46:26Z
_version_	1777409706236575744

A Study of Paraoxonase (PON-1) Activity and Concentration in Coronary Artery Disease Patients in Kuantan, Pahang

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