Bioactive terpenoids from the stem bark of Entada spiralis Ridl.(Sintok)

The application of Entada sipralis Ridl. (Leguminoceae) stem bark containing saponin in the treatment of scalp and as body soap is well known for generations. Our previous investigation revealed E. spiralis stem bark contains several of terpenoid compounds and are responsible for the inhibitory effe...

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Main Authors:	Harun, Aiza, Mat So'ad, Siti Zaiton, Mohd Hassan, Norazian, Che Mohd Ramli, Neni Kartini
Format:	Conference or Workshop Item
Language:	English English
Published:	2012
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/32226/ http://irep.iium.edu.my/32226/ http://irep.iium.edu.my/32226/3/stssaiza.pdf http://irep.iium.edu.my/32226/5/Aiza11062012.pdf

id	iium-32226
recordtype	eprints
spelling	iium-322262014-11-26T05:22:07Z http://irep.iium.edu.my/32226/ Bioactive terpenoids from the stem bark of Entada spiralis Ridl.(Sintok) Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini QD Chemistry The application of Entada sipralis Ridl. (Leguminoceae) stem bark containing saponin in the treatment of scalp and as body soap is well known for generations. Our previous investigation revealed E. spiralis stem bark contains several of terpenoid compounds and are responsible for the inhibitory effect against bacteria Staphyloccus epidermis ATCC 12228 and skin disease dermatophytes, Microsporum gypseum ATCC 24102, Trichophyton mentagrophytes ATCC 9533 and Trichophyton tonsurans ATCC 28942. The aim of this work is to isolate and identify the chemical structure of some terpenoid compounds from the active fraction of E. spiralis stem bark. The isolation of active compounds was conducted by means of chromatographic separation, and the structure characterization was done based on spectroscopic analysis (1H,13C NMR, HMQC, HMBC and DEPT135) and comparison with those of the literature. We managed to isolate two terpenoid compounds known as ester saponin (1) and terpene benzoate (2). The extensive 1D and 2D Nuclear Magnetic Resonans (NMR) experiments identified (1) as 16-β-D-arabinofuranosyl-15-β-D-xylopyranosyl-5,8,9,10-tetrahydroxyl-17,18,19,20-tetramethyl diterpene ester and (2) as 4-(β-D-glucopyranosyl)-1-hydroxybenzene-(20-hydroxyl-18,19dimethylcyclotetradecanol) benzoate. The isolation and characterization of (1) and (2) is hoped to give new impact on the search of new natural antimicrobial drug as the compounds are not pharmacologically and chemically investigated to date. 2012 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/32226/3/stssaiza.pdf application/pdf en http://irep.iium.edu.my/32226/5/Aiza11062012.pdf Harun, Aiza and Mat So'ad, Siti Zaiton and Mohd Hassan, Norazian and Che Mohd Ramli, Neni Kartini (2012) Bioactive terpenoids from the stem bark of Entada spiralis Ridl.(Sintok). In: International Conference on Science, Technology & Social Science (ICSTSS2012), 21-22 Nov 2012, Kuantan, Pahang. http://icstss.phg.my/2012/index.php
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini Bioactive terpenoids from the stem bark of Entada spiralis Ridl.(Sintok)
description	The application of Entada sipralis Ridl. (Leguminoceae) stem bark containing saponin in the treatment of scalp and as body soap is well known for generations. Our previous investigation revealed E. spiralis stem bark contains several of terpenoid compounds and are responsible for the inhibitory effect against bacteria Staphyloccus epidermis ATCC 12228 and skin disease dermatophytes, Microsporum gypseum ATCC 24102, Trichophyton mentagrophytes ATCC 9533 and Trichophyton tonsurans ATCC 28942. The aim of this work is to isolate and identify the chemical structure of some terpenoid compounds from the active fraction of E. spiralis stem bark. The isolation of active compounds was conducted by means of chromatographic separation, and the structure characterization was done based on spectroscopic analysis (1H,13C NMR, HMQC, HMBC and DEPT135) and comparison with those of the literature. We managed to isolate two terpenoid compounds known as ester saponin (1) and terpene benzoate (2). The extensive 1D and 2D Nuclear Magnetic Resonans (NMR) experiments identified (1) as 16-β-D-arabinofuranosyl-15-β-D-xylopyranosyl-5,8,9,10-tetrahydroxyl-17,18,19,20-tetramethyl diterpene ester and (2) as 4-(β-D-glucopyranosyl)-1-hydroxybenzene-(20-hydroxyl-18,19dimethylcyclotetradecanol) benzoate. The isolation and characterization of (1) and (2) is hoped to give new impact on the search of new natural antimicrobial drug as the compounds are not pharmacologically and chemically investigated to date.
format	Conference or Workshop Item
author	Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini
author_facet	Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini
author_sort	Harun, Aiza
title	Bioactive terpenoids from the stem bark of Entada spiralis Ridl.(Sintok)
title_short	Bioactive terpenoids from the stem bark of Entada spiralis Ridl.(Sintok)
title_full	Bioactive terpenoids from the stem bark of Entada spiralis Ridl.(Sintok)
title_fullStr	Bioactive terpenoids from the stem bark of Entada spiralis Ridl.(Sintok)
title_full_unstemmed	Bioactive terpenoids from the stem bark of Entada spiralis Ridl.(Sintok)
title_sort	bioactive terpenoids from the stem bark of entada spiralis ridl.(sintok)
publishDate	2012
url	http://irep.iium.edu.my/32226/ http://irep.iium.edu.my/32226/ http://irep.iium.edu.my/32226/3/stssaiza.pdf http://irep.iium.edu.my/32226/5/Aiza11062012.pdf
first_indexed	2023-09-18T20:46:31Z
last_indexed	2023-09-18T20:46:31Z
_version_	1777409711228846080

Bioactive terpenoids from the stem bark of Entada spiralis Ridl.(Sintok)

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