Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves

A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of Misai kucing (Orthisphon stamineus) was developed. In this study, adenosine A1 receptor binding, which is related to the diuretic action in the treatment of kidney stones was tested. A combinat...

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Main Authors:	Khatib, Alfi, Yuliana, Nancy Dewi
Format:	Conference or Workshop Item
Language:	English English English English
Published:	2013
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/33290/ http://irep.iium.edu.my/33290/ http://irep.iium.edu.my/33290/1/certificate.pdf http://irep.iium.edu.my/33290/2/proceeding1.pdf http://irep.iium.edu.my/33290/3/proceeding2.pdf http://irep.iium.edu.my/33290/4/poster.pdf

id	iium-33290
recordtype	eprints
spelling	iium-332902013-12-16T03:09:10Z http://irep.iium.edu.my/33290/ Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves Khatib, Alfi Yuliana, Nancy Dewi QD Chemistry A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of Misai kucing (Orthisphon stamineus) was developed. In this study, adenosine A1 receptor binding, which is related to the diuretic action in the treatment of kidney stones was tested. A combination of thin layer chromatography of different extracts prepared by extraction with diverse solvents (n-hexane, chloroform, n-butanol and water), and multivariate data analysis based on orthogonal partial least squares proved to be a promising approach to determine these active compounds. Several methoxy flavonoids, fatty acids or terpenoids were estimated to be related o this activity. The results of this study support the traditional use of O. stamineus to treat kidney stone in Malaysia. 2013-09-06 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/33290/1/certificate.pdf application/pdf en http://irep.iium.edu.my/33290/2/proceeding1.pdf application/pdf en http://irep.iium.edu.my/33290/3/proceeding2.pdf application/pdf en http://irep.iium.edu.my/33290/4/poster.pdf Khatib, Alfi and Yuliana, Nancy Dewi (2013) Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves. In: 27th Scientific Meeting of Malaysian Society of Pharmacology and Physiology (MSPP2013), 6-8 Sep 2013, MS Garden Kuantan. http://www.mspp2013.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	QD Chemistry
spellingShingle	QD Chemistry Khatib, Alfi Yuliana, Nancy Dewi Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves
description	A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of Misai kucing (Orthisphon stamineus) was developed. In this study, adenosine A1 receptor binding, which is related to the diuretic action in the treatment of kidney stones was tested. A combination of thin layer chromatography of different extracts prepared by extraction with diverse solvents (n-hexane, chloroform, n-butanol and water), and multivariate data analysis based on orthogonal partial least squares proved to be a promising approach to determine these active compounds. Several methoxy flavonoids, fatty acids or terpenoids were estimated to be related o this activity. The results of this study support the traditional use of O. stamineus to treat kidney stone in Malaysia.
format	Conference or Workshop Item
author	Khatib, Alfi Yuliana, Nancy Dewi
author_facet	Khatib, Alfi Yuliana, Nancy Dewi
author_sort	Khatib, Alfi
title	Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves
title_short	Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves
title_full	Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves
title_fullStr	Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves
title_full_unstemmed	Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves
title_sort	application of tlc-based metabolomics to identify bioactive compounds possessing adenosine a1 receptor binding activity in misai kucing (orthosphon stamineus) leaves
publishDate	2013
url	http://irep.iium.edu.my/33290/ http://irep.iium.edu.my/33290/ http://irep.iium.edu.my/33290/1/certificate.pdf http://irep.iium.edu.my/33290/2/proceeding1.pdf http://irep.iium.edu.my/33290/3/proceeding2.pdf http://irep.iium.edu.my/33290/4/poster.pdf
first_indexed	2023-09-18T20:48:07Z
last_indexed	2023-09-18T20:48:07Z
_version_	1777409811830276096

Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves

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