Metabolomics for bioactivity assessment of natural products
Natural products historically have been a rich source of lead molecules in drug discovery, based on their capability to create unique and diverse chemical structures. However, it is also true that the vast number of metabolites typically present in natural products and their huge dynamic range res...
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John Wiley and Son, Ltd
2011
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| Online Access: | http://irep.iium.edu.my/33306/ http://irep.iium.edu.my/33306/ http://irep.iium.edu.my/33306/ http://irep.iium.edu.my/33306/1/Yuliana-N.D._Metabolomics-for-bioactivity-assessment-of-natural-products_2011.pdf |
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iium-333062013-12-12T14:05:49Z http://irep.iium.edu.my/33306/ Metabolomics for bioactivity assessment of natural products Yuliana, Nancy Dewi Khatib, Alfi Choi, Young Hae Verpoorte, Robert QD Chemistry Natural products historically have been a rich source of lead molecules in drug discovery, based on their capability to create unique and diverse chemical structures. However, it is also true that the vast number of metabolites typically present in natural products and their huge dynamic range results in the loss of many possibly bioactive natural compounds, becoming an inextricable obstacle for drug development. Recently, new strategies which favour a holistic approach as opposed to the traditional reductionist methods used previously, have been introduced with the purpose of overcoming the bottlenecks in natural product research. This approach is based on the application of new technologies, including metabolomics, for example. Metabolomics allows a systematic study of a complex mixture such as a phytochemical preparation, which can be linked to observations obtained through biological testing systems without the need for isolating active principles. This may put drug discovery from natural products back in the limelight again. In this review paper, the description of some examples of successful metabolomics applications in several important fields related to drug discovery from natural sources aims at raising the potential of metabolomics in reducing the gap between natural products (NP) and modern drug discovery demand. John Wiley and Son, Ltd 2011-01-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/33306/1/Yuliana-N.D._Metabolomics-for-bioactivity-assessment-of-natural-products_2011.pdf Yuliana, Nancy Dewi and Khatib, Alfi and Choi, Young Hae and Verpoorte, Robert (2011) Metabolomics for bioactivity assessment of natural products. Phytotherapy Research, 25 (2). pp. 157-169. ISSN 1099-1573 http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291099-1573 10.1002/ptr.3258 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
QD Chemistry |
| spellingShingle |
QD Chemistry Yuliana, Nancy Dewi Khatib, Alfi Choi, Young Hae Verpoorte, Robert Metabolomics for bioactivity assessment of natural products |
| description |
Natural products historically have been a rich source of lead molecules in drug discovery, based on their
capability to create unique and diverse chemical structures. However, it is also true that the vast number of
metabolites typically present in natural products and their huge dynamic range results in the loss of many
possibly bioactive natural compounds, becoming an inextricable obstacle for drug development. Recently, new
strategies which favour a holistic approach as opposed to the traditional reductionist methods used previously,
have been introduced with the purpose of overcoming the bottlenecks in natural product research. This
approach is based on the application of new technologies, including metabolomics, for example. Metabolomics
allows a systematic study of a complex mixture such as a phytochemical preparation, which can be linked to
observations obtained through biological testing systems without the need for isolating active principles. This
may put drug discovery from natural products back in the limelight again. In this review paper, the description
of some examples of successful metabolomics applications in several important fields related to drug discovery
from natural sources aims at raising the potential of metabolomics in reducing the gap between natural products
(NP) and modern drug discovery demand. |
| format |
Article |
| author |
Yuliana, Nancy Dewi Khatib, Alfi Choi, Young Hae Verpoorte, Robert |
| author_facet |
Yuliana, Nancy Dewi Khatib, Alfi Choi, Young Hae Verpoorte, Robert |
| author_sort |
Yuliana, Nancy Dewi |
| title |
Metabolomics for bioactivity assessment of natural products |
| title_short |
Metabolomics for bioactivity assessment of natural products |
| title_full |
Metabolomics for bioactivity assessment of natural products |
| title_fullStr |
Metabolomics for bioactivity assessment of natural products |
| title_full_unstemmed |
Metabolomics for bioactivity assessment of natural products |
| title_sort |
metabolomics for bioactivity assessment of natural products |
| publisher |
John Wiley and Son, Ltd |
| publishDate |
2011 |
| url |
http://irep.iium.edu.my/33306/ http://irep.iium.edu.my/33306/ http://irep.iium.edu.my/33306/ http://irep.iium.edu.my/33306/1/Yuliana-N.D._Metabolomics-for-bioactivity-assessment-of-natural-products_2011.pdf |
| first_indexed |
2023-09-18T20:48:08Z |
| last_indexed |
2023-09-18T20:48:08Z |
| _version_ |
1777409813601320960 |