Age-related rarefaction in retinal vasculature is not linear

The fractal dimension is a global measure of complexity and is useful for quantifying anatomical structures, including the retinal vascular network. A previous study found a linear declining trend with aging on the retinal vascular fractal dimension (DF); however, it was limited to the older populat...

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Main Authors:	Che Azemin, Mohd Zulfaezal, Ab Hamid, F., Aminuddin, A., Wang, J.J., Kawasaki, R., Kumar, D.K.
Format:	Article
Language:	English
Published:	Elsevier 2013
Subjects:	RE Ophthalmology TK7885 Computer engineering
Online Access:	http://irep.iium.edu.my/33330/ http://irep.iium.edu.my/33330/ http://irep.iium.edu.my/33330/ http://irep.iium.edu.my/33330/1/ExpEyeRes2013.pdf

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spelling	iium-333302013-12-16T04:31:41Z http://irep.iium.edu.my/33330/ Age-related rarefaction in retinal vasculature is not linear Che Azemin, Mohd Zulfaezal Ab Hamid, F. Aminuddin, A. Wang, J.J. Kawasaki, R. Kumar, D.K. RE Ophthalmology TK7885 Computer engineering The fractal dimension is a global measure of complexity and is useful for quantifying anatomical structures, including the retinal vascular network. A previous study found a linear declining trend with aging on the retinal vascular fractal dimension (DF); however, it was limited to the older population (49 years and older). This study aimed to investigate the possible models of the fractal dimension changes from young to old subjects (10-73 years). A total of 215 right-eye retinal samples, including those of 119 (55%) women and 96 (45%) men, were selected. The retinal vessels were segmented using computer-assisted software, and non-vessel fragments were deleted. The fractal dimension was measured based on the log-log plot of the number of grids versus the size. The retinal vascular DF was analyzed to determine changes with increasing age. Finally, the data were fitted to three polynomial models. All three models are statistically significant (Linear: R2 = 0.1270, 213 d.f., p < 0.001, Quadratic: R2 = 0.1536, 212 d.f., p < 0.001, Cubic: R2 = 0.1529, 211 d.f., p < 0.001). The quadratic regression is significantly better than the linear regression (p < 0.001); however, the increase in R2 from the quadratic model to the cubic model is not significant (p = 0.97). These results suggest that the decreasing trend of the fractal dimension associated with aging is better explained by the quadratic model than by the linear and cubic models in a sample with a broader age spectrum. Elsevier 2013-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/33330/1/ExpEyeRes2013.pdf Che Azemin, Mohd Zulfaezal and Ab Hamid, F. and Aminuddin, A. and Wang, J.J. and Kawasaki, R. and Kumar, D.K. (2013) Age-related rarefaction in retinal vasculature is not linear. Experimental Eye Research, 116. pp. 355-358. ISSN 0014-4835 http://www.sciencedirect.com/science/journal/00144835/116 http://dx.doi.org/10.1016/j.exer.2013.10.010
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RE Ophthalmology TK7885 Computer engineering
spellingShingle	RE Ophthalmology TK7885 Computer engineering Che Azemin, Mohd Zulfaezal Ab Hamid, F. Aminuddin, A. Wang, J.J. Kawasaki, R. Kumar, D.K. Age-related rarefaction in retinal vasculature is not linear
description	The fractal dimension is a global measure of complexity and is useful for quantifying anatomical structures, including the retinal vascular network. A previous study found a linear declining trend with aging on the retinal vascular fractal dimension (DF); however, it was limited to the older population (49 years and older). This study aimed to investigate the possible models of the fractal dimension changes from young to old subjects (10-73 years). A total of 215 right-eye retinal samples, including those of 119 (55%) women and 96 (45%) men, were selected. The retinal vessels were segmented using computer-assisted software, and non-vessel fragments were deleted. The fractal dimension was measured based on the log-log plot of the number of grids versus the size. The retinal vascular DF was analyzed to determine changes with increasing age. Finally, the data were fitted to three polynomial models. All three models are statistically significant (Linear: R2 = 0.1270, 213 d.f., p < 0.001, Quadratic: R2 = 0.1536, 212 d.f., p < 0.001, Cubic: R2 = 0.1529, 211 d.f., p < 0.001). The quadratic regression is significantly better than the linear regression (p < 0.001); however, the increase in R2 from the quadratic model to the cubic model is not significant (p = 0.97). These results suggest that the decreasing trend of the fractal dimension associated with aging is better explained by the quadratic model than by the linear and cubic models in a sample with a broader age spectrum.
format	Article
author	Che Azemin, Mohd Zulfaezal Ab Hamid, F. Aminuddin, A. Wang, J.J. Kawasaki, R. Kumar, D.K.
author_facet	Che Azemin, Mohd Zulfaezal Ab Hamid, F. Aminuddin, A. Wang, J.J. Kawasaki, R. Kumar, D.K.
author_sort	Che Azemin, Mohd Zulfaezal
title	Age-related rarefaction in retinal vasculature is not linear
title_short	Age-related rarefaction in retinal vasculature is not linear
title_full	Age-related rarefaction in retinal vasculature is not linear
title_fullStr	Age-related rarefaction in retinal vasculature is not linear
title_full_unstemmed	Age-related rarefaction in retinal vasculature is not linear
title_sort	age-related rarefaction in retinal vasculature is not linear
publisher	Elsevier
publishDate	2013
url	http://irep.iium.edu.my/33330/ http://irep.iium.edu.my/33330/ http://irep.iium.edu.my/33330/ http://irep.iium.edu.my/33330/1/ExpEyeRes2013.pdf
first_indexed	2023-09-18T20:48:10Z
last_indexed	2023-09-18T20:48:10Z
_version_	1777409815406968832

Age-related rarefaction in retinal vasculature is not linear

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