Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study
Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine, International Islamic University Malaysia
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/33340/ http://irep.iium.edu.my/33340/ http://irep.iium.edu.my/33340/1/Vol12No2%2520Page%252003-10.pdf |
| Summary: | Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal
disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate
the potential effects of XSYWW on ethanol-induced gastric ulcer in rats by means of histological Study. On a
similar basis of treatment, ranitidine, a conventional medication was used as gold standard. Methods: Fifty
five male Sprague-Dawley rats (250-300 gm) were divided into four groups. Group I (ethanol treated group)
was the control group and gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II
(Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg
respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I.
Group III, was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Group
IV was given an oral dose of 200mg/kg ranitidine solution after one hour of ethanol administration. Five rats
from groups I, III and IV were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour
after ethanol administration. Results: Histological study of the stomachs from ethanol treated rats showed
multiple ulcers of various depths that reached the muscularis and the serosa. Conclusion: Pre or post-treated
rats with XSYWW showed that XSYWW has protective effect against ethanol-induced gastric mucosal lesion.
However, there was a faster and more complete healing process in the ranitidine treated group when compared
to the XSYWW treated subjects. |
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