Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study

Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats...

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Main Authors:	Al-Qaraghuli , Ahmed S, Abdel Wahab, Emad M N, Al-Ani, Imad Matloub Dally, Faisal, Ghasak Ghazi
Format:	Article
Language:	English
Published:	Faculty of Medicine, International Islamic University Malaysia 2013
Subjects:	QM Human anatomy QP Physiology RB Pathology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/33340/ http://irep.iium.edu.my/33340/ http://irep.iium.edu.my/33340/1/Vol12No2%2520Page%252003-10.pdf

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spelling	iium-333402015-12-18T02:36:54Z http://irep.iium.edu.my/33340/ Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study Al-Qaraghuli , Ahmed S Abdel Wahab, Emad M N Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi QM Human anatomy QP Physiology RB Pathology RS Pharmacy and materia medica Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats by means of histological Study. On a similar basis of treatment, ranitidine, a conventional medication was used as gold standard. Methods: Fifty five male Sprague-Dawley rats (250-300 gm) were divided into four groups. Group I (ethanol treated group) was the control group and gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II (Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I. Group III, was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Group IV was given an oral dose of 200mg/kg ranitidine solution after one hour of ethanol administration. Five rats from groups I, III and IV were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour after ethanol administration. Results: Histological study of the stomachs from ethanol treated rats showed multiple ulcers of various depths that reached the muscularis and the serosa. Conclusion: Pre or post-treated rats with XSYWW showed that XSYWW has protective effect against ethanol-induced gastric mucosal lesion. However, there was a faster and more complete healing process in the ranitidine treated group when compared to the XSYWW treated subjects. Faculty of Medicine, International Islamic University Malaysia 2013-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/33340/1/Vol12No2%2520Page%252003-10.pdf Al-Qaraghuli , Ahmed S and Abdel Wahab, Emad M N and Al-Ani, Imad Matloub Dally and Faisal, Ghasak Ghazi (2013) Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study. International Medical Journal Malaysia, 12 (2). pp. 3-10. ISSN 1823-4631 http://www.e-imj.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QM Human anatomy QP Physiology RB Pathology RS Pharmacy and materia medica
spellingShingle	QM Human anatomy QP Physiology RB Pathology RS Pharmacy and materia medica Al-Qaraghuli , Ahmed S Abdel Wahab, Emad M N Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study
description	Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats by means of histological Study. On a similar basis of treatment, ranitidine, a conventional medication was used as gold standard. Methods: Fifty five male Sprague-Dawley rats (250-300 gm) were divided into four groups. Group I (ethanol treated group) was the control group and gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II (Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I. Group III, was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Group IV was given an oral dose of 200mg/kg ranitidine solution after one hour of ethanol administration. Five rats from groups I, III and IV were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour after ethanol administration. Results: Histological study of the stomachs from ethanol treated rats showed multiple ulcers of various depths that reached the muscularis and the serosa. Conclusion: Pre or post-treated rats with XSYWW showed that XSYWW has protective effect against ethanol-induced gastric mucosal lesion. However, there was a faster and more complete healing process in the ranitidine treated group when compared to the XSYWW treated subjects.
format	Article
author	Al-Qaraghuli , Ahmed S Abdel Wahab, Emad M N Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi
author_facet	Al-Qaraghuli , Ahmed S Abdel Wahab, Emad M N Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi
author_sort	Al-Qaraghuli , Ahmed S
title	Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study
title_short	Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study
title_full	Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study
title_fullStr	Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study
title_full_unstemmed	Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study
title_sort	effects of xiang sha yang wei wan on ethanol-induced gastric ulcer in sprague dawley rats: a histological study
publisher	Faculty of Medicine, International Islamic University Malaysia
publishDate	2013
url	http://irep.iium.edu.my/33340/ http://irep.iium.edu.my/33340/ http://irep.iium.edu.my/33340/1/Vol12No2%2520Page%252003-10.pdf
first_indexed	2023-09-18T20:48:11Z
last_indexed	2023-09-18T20:48:11Z
_version_	1777409816114757632

Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study

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