Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis

The present study focuses on the bioassay guided isolation of antimicrobial compounds from Artocarpus altilis. The hexane, dichloromethane and methanol extracts were obtained from the dried (twigs of A. altilis) by using Soxhlet extraction. The plant crude extracts were evaluated for in vitro antimi...

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Main Authors:	Omar, Muhammad Nor, Zuberdi, Ahmad Muzammil, Khan, Naik T., Abdul Aziz, Muhammad Zahid, Kamal, Tara
Format:	Article
Language:	English
Published:	Merit Research Journal 2013
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/33451/ http://irep.iium.edu.my/33451/ http://irep.iium.edu.my/33451/1/Artocarpus_altilis_MRJEST.pdf

id	iium-33451
recordtype	eprints
spelling	iium-334512013-12-16T01:37:42Z http://irep.iium.edu.my/33451/ Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis Omar, Muhammad Nor Zuberdi, Ahmad Muzammil Khan, Naik T. Abdul Aziz, Muhammad Zahid Kamal, Tara QD Chemistry The present study focuses on the bioassay guided isolation of antimicrobial compounds from Artocarpus altilis. The hexane, dichloromethane and methanol extracts were obtained from the dried (twigs of A. altilis) by using Soxhlet extraction. The plant crude extracts were evaluated for in vitro antimicrobial and antioxidant activities revealed that twigs part of A. altilis had potent antimicrobial activities, further purification had been done through column chromatography(CC) of dichloromethane and hexane extracts of A. altilis, which were afforded stigmasterol and cycloartenyl acetate respectively, the two compounds exhibited in vitro antimicrobial activity against S. aureus value of (11±0.5mm) and (11.3±0.5mm). Whereas minimum inhibition concetration (MIC) and minimum bactericidal/minimum fungicidal concetration (MBC/MFC) for isolated compounds were ranged from 62.5-500 µg/ml. Their structures were identified by 1H-NMR, 13C-NMR, IR and the spectra obtained were compared with previous data. This study forms a strong basis for declaring A. altilis as antimicrobial potential source to treat pathogenic microorganisms. Merit Research Journal 2013-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/33451/1/Artocarpus_altilis_MRJEST.pdf Omar, Muhammad Nor and Zuberdi, Ahmad Muzammil and Khan, Naik T. and Abdul Aziz, Muhammad Zahid and Kamal, Tara (2013) Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis. Merit Research Journal of Environmental Science and Toxicology, 1 (8). pp. 147-155. ISSN 2350-2266 http://www.meritresearchjournals.org/est/index.htm
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Omar, Muhammad Nor Zuberdi, Ahmad Muzammil Khan, Naik T. Abdul Aziz, Muhammad Zahid Kamal, Tara Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis
description	The present study focuses on the bioassay guided isolation of antimicrobial compounds from Artocarpus altilis. The hexane, dichloromethane and methanol extracts were obtained from the dried (twigs of A. altilis) by using Soxhlet extraction. The plant crude extracts were evaluated for in vitro antimicrobial and antioxidant activities revealed that twigs part of A. altilis had potent antimicrobial activities, further purification had been done through column chromatography(CC) of dichloromethane and hexane extracts of A. altilis, which were afforded stigmasterol and cycloartenyl acetate respectively, the two compounds exhibited in vitro antimicrobial activity against S. aureus value of (11±0.5mm) and (11.3±0.5mm). Whereas minimum inhibition concetration (MIC) and minimum bactericidal/minimum fungicidal concetration (MBC/MFC) for isolated compounds were ranged from 62.5-500 µg/ml. Their structures were identified by 1H-NMR, 13C-NMR, IR and the spectra obtained were compared with previous data. This study forms a strong basis for declaring A. altilis as antimicrobial potential source to treat pathogenic microorganisms.
format	Article
author	Omar, Muhammad Nor Zuberdi, Ahmad Muzammil Khan, Naik T. Abdul Aziz, Muhammad Zahid Kamal, Tara
author_facet	Omar, Muhammad Nor Zuberdi, Ahmad Muzammil Khan, Naik T. Abdul Aziz, Muhammad Zahid Kamal, Tara
author_sort	Omar, Muhammad Nor
title	Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis
title_short	Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis
title_full	Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis
title_fullStr	Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis
title_full_unstemmed	Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis
title_sort	isolation and identification of bioactive compounds from twigs of artocarpus altilis
publisher	Merit Research Journal
publishDate	2013
url	http://irep.iium.edu.my/33451/ http://irep.iium.edu.my/33451/ http://irep.iium.edu.my/33451/1/Artocarpus_altilis_MRJEST.pdf
first_indexed	2023-09-18T20:48:21Z
last_indexed	2023-09-18T20:48:21Z
_version_	1777409826364588032

Isolation and identification of bioactive compounds from twigs of Artocarpus Altilis

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