The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney

Proteus mirabilis has previously been shown to be capable of persisting in the rat kidney for up to 8 weeks and induces many physiological changes following a single inoculation of the urinary bladder. The present study examined kidney tissue from infected animals for evidence of renal damage.The e...

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Main Authors:	Al-Ani, Imad Matloub Dally, Al-Murayati, H.Y., Ghani, H.M.
Format:	Conference or Workshop Item
Language:	English English English
Published:	2011
Subjects:	QM Human anatomy QP Physiology QR Microbiology RB Pathology
Online Access:	http://irep.iium.edu.my/33496/ http://irep.iium.edu.my/33496/1/COVER_PAGE.pdf http://irep.iium.edu.my/33496/2/ABSTRACT.pdf http://irep.iium.edu.my/33496/3/CERTIFICATE.pdf

id	iium-33496
recordtype	eprints
spelling	iium-334962015-12-18T02:48:16Z http://irep.iium.edu.my/33496/ The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney Al-Ani, Imad Matloub Dally Al-Murayati, H.Y. Ghani, H.M. QM Human anatomy QP Physiology QR Microbiology RB Pathology Proteus mirabilis has previously been shown to be capable of persisting in the rat kidney for up to 8 weeks and induces many physiological changes following a single inoculation of the urinary bladder. The present study examined kidney tissue from infected animals for evidence of renal damage.The earliest histologic changes seen on the 2nd and 4th days, consisted of mild cellular sloughing and edema associated with mononuclear infiltration in the medulla and to a lesser extent in the cortex. On the 1st and following weeks, tubular atrophy, interstitial fibrosis, and a mononuclear infiltrate had advanced in the renal parenchyma re-sulting in chronic pyelonephritis. The observed renal degenerations with a corresponding ascending bacterial infection in the intra-renal reflux suggest that Proteus mirabilis is capable of producing chronic pyelonephritis in the rats after a single reflux challenge. Key Words: Kidney, Proteus mirabilis, Pyelonephritis, Rats, Urinary tract. 2011 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/33496/1/COVER_PAGE.pdf application/pdf en http://irep.iium.edu.my/33496/2/ABSTRACT.pdf application/pdf en http://irep.iium.edu.my/33496/3/CERTIFICATE.pdf Al-Ani, Imad Matloub Dally and Al-Murayati, H.Y. and Ghani, H.M. (2011) The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney. In: 2nd Malaysian Anatomical Conference, 8-9 June 2011, Shah Alam, Selangor. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QM Human anatomy QP Physiology QR Microbiology RB Pathology
spellingShingle	QM Human anatomy QP Physiology QR Microbiology RB Pathology Al-Ani, Imad Matloub Dally Al-Murayati, H.Y. Ghani, H.M. The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney
description	Proteus mirabilis has previously been shown to be capable of persisting in the rat kidney for up to 8 weeks and induces many physiological changes following a single inoculation of the urinary bladder. The present study examined kidney tissue from infected animals for evidence of renal damage.The earliest histologic changes seen on the 2nd and 4th days, consisted of mild cellular sloughing and edema associated with mononuclear infiltration in the medulla and to a lesser extent in the cortex. On the 1st and following weeks, tubular atrophy, interstitial fibrosis, and a mononuclear infiltrate had advanced in the renal parenchyma re-sulting in chronic pyelonephritis. The observed renal degenerations with a corresponding ascending bacterial infection in the intra-renal reflux suggest that Proteus mirabilis is capable of producing chronic pyelonephritis in the rats after a single reflux challenge. Key Words: Kidney, Proteus mirabilis, Pyelonephritis, Rats, Urinary tract.
format	Conference or Workshop Item
author	Al-Ani, Imad Matloub Dally Al-Murayati, H.Y. Ghani, H.M.
author_facet	Al-Ani, Imad Matloub Dally Al-Murayati, H.Y. Ghani, H.M.
author_sort	Al-Ani, Imad Matloub Dally
title	The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney
title_short	The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney
title_full	The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney
title_fullStr	The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney
title_full_unstemmed	The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney
title_sort	effect of proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney
publishDate	2011
url	http://irep.iium.edu.my/33496/ http://irep.iium.edu.my/33496/1/COVER_PAGE.pdf http://irep.iium.edu.my/33496/2/ABSTRACT.pdf http://irep.iium.edu.my/33496/3/CERTIFICATE.pdf
first_indexed	2023-09-18T20:48:26Z
last_indexed	2023-09-18T20:48:26Z
_version_	1777409831494221824

The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney

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