Study of oxidized low density lipoprotein and augmentation index among population

Arterial stiffness is defined as the hardening of the arteries due to loss of their elastic properties. Stiffening of arterial wall can be a good biomarker for increased cardiovascular disease thus measuring arterial stiffness is recommended in the preventive management of cardiovascular disease. A...

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Main Authors:	Nazir, Mohd Hakam, Aung, Nilar, Abdullah, Nor Zamzila, Samsuddin, Niza
Format:	Conference or Workshop Item
Language:	English English English
Published:	2013
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/33734/ http://irep.iium.edu.my/33734/1/5_001%2C_Certificate%2C_MSPP%2C_13.jpg http://irep.iium.edu.my/33734/2/1_001%2C_MSPP%2C13.jpg http://irep.iium.edu.my/33734/13/Final_poster_master_2013_%28_MSPP%29.pdf

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spelling	iium-337342014-01-13T08:32:13Z http://irep.iium.edu.my/33734/ Study of oxidized low density lipoprotein and augmentation index among population Nazir, Mohd Hakam Aung, Nilar Abdullah, Nor Zamzila Samsuddin, Niza R Medicine (General) Arterial stiffness is defined as the hardening of the arteries due to loss of their elastic properties. Stiffening of arterial wall can be a good biomarker for increased cardiovascular disease thus measuring arterial stiffness is recommended in the preventive management of cardiovascular disease. Arterial stiffness is also associated with a number of cardiovascular disease risk factors like age, smoking, gender, hypertension, obesity, hypercholesterolemia and diabetes. The aim of this research is to study the ox-LDL and augmentation index (AIx) among apparently healthy subjects in ‘Chengal Lempong’ village together with their associations. The subjects (n=85) of age (>18 years) were randomly selected as participants in the study. A sandwich enzyme-linked immunoadsorbent assay (ELISA) was used to measure ox-LDL. The augmentation index (AIx) which reflects the arterial stiffness was determined by using non-invasive applanation tonometry, Sphygmo Cor. The current study showed that mean of the age was 40±8 years with male and female distribution of 38(45%) and 47(55%) respectively. 35.3% of the subjects were obese and 41.2% were overweight. 23 (28%) of them were smoker. There was a significant positive correlation between age and ox-LDL (r = 0.4, p <0.05). AIx was positively correlated with gender (p< 0.05) and smoking (p< 0.05). There was a positive correlation between ox- LDL and AIx ( r = 0.2 at p= 0.05) . The present study found that a higher ox-LDL was related with increased AIx. This showed that the increased arterial stiffness suggesting that oxidative modification of oxidized LDL may affect in the alteration of arterial wall elastic properties. 2013-12-27 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/33734/1/5_001%2C_Certificate%2C_MSPP%2C_13.jpg application/pdf en http://irep.iium.edu.my/33734/2/1_001%2C_MSPP%2C13.jpg application/pdf en http://irep.iium.edu.my/33734/13/Final_poster_master_2013_%28_MSPP%29.pdf Nazir, Mohd Hakam and Aung, Nilar and Abdullah, Nor Zamzila and Samsuddin, Niza (2013) Study of oxidized low density lipoprotein and augmentation index among population. In: 27th Scientific Meeting of Malaysian Society of Pharmacology and Physiology (MSPP2013), 6-8 September 2013, MS Garden Kuantan. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Nazir, Mohd Hakam Aung, Nilar Abdullah, Nor Zamzila Samsuddin, Niza Study of oxidized low density lipoprotein and augmentation index among population
description	Arterial stiffness is defined as the hardening of the arteries due to loss of their elastic properties. Stiffening of arterial wall can be a good biomarker for increased cardiovascular disease thus measuring arterial stiffness is recommended in the preventive management of cardiovascular disease. Arterial stiffness is also associated with a number of cardiovascular disease risk factors like age, smoking, gender, hypertension, obesity, hypercholesterolemia and diabetes. The aim of this research is to study the ox-LDL and augmentation index (AIx) among apparently healthy subjects in ‘Chengal Lempong’ village together with their associations. The subjects (n=85) of age (>18 years) were randomly selected as participants in the study. A sandwich enzyme-linked immunoadsorbent assay (ELISA) was used to measure ox-LDL. The augmentation index (AIx) which reflects the arterial stiffness was determined by using non-invasive applanation tonometry, Sphygmo Cor. The current study showed that mean of the age was 40±8 years with male and female distribution of 38(45%) and 47(55%) respectively. 35.3% of the subjects were obese and 41.2% were overweight. 23 (28%) of them were smoker. There was a significant positive correlation between age and ox-LDL (r = 0.4, p <0.05). AIx was positively correlated with gender (p< 0.05) and smoking (p< 0.05). There was a positive correlation between ox- LDL and AIx ( r = 0.2 at p= 0.05) . The present study found that a higher ox-LDL was related with increased AIx. This showed that the increased arterial stiffness suggesting that oxidative modification of oxidized LDL may affect in the alteration of arterial wall elastic properties.
format	Conference or Workshop Item
author	Nazir, Mohd Hakam Aung, Nilar Abdullah, Nor Zamzila Samsuddin, Niza
author_facet	Nazir, Mohd Hakam Aung, Nilar Abdullah, Nor Zamzila Samsuddin, Niza
author_sort	Nazir, Mohd Hakam
title	Study of oxidized low density lipoprotein and augmentation index among population
title_short	Study of oxidized low density lipoprotein and augmentation index among population
title_full	Study of oxidized low density lipoprotein and augmentation index among population
title_fullStr	Study of oxidized low density lipoprotein and augmentation index among population
title_full_unstemmed	Study of oxidized low density lipoprotein and augmentation index among population
title_sort	study of oxidized low density lipoprotein and augmentation index among population
publishDate	2013
url	http://irep.iium.edu.my/33734/ http://irep.iium.edu.my/33734/1/5_001%2C_Certificate%2C_MSPP%2C_13.jpg http://irep.iium.edu.my/33734/2/1_001%2C_MSPP%2C13.jpg http://irep.iium.edu.my/33734/13/Final_poster_master_2013_%28_MSPP%29.pdf
first_indexed	2023-09-18T20:48:47Z
last_indexed	2023-09-18T20:48:47Z
_version_	1777409854301798400

Study of oxidized low density lipoprotein and augmentation index among population

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