Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms

Objective: To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and fungi. Methods: The experiment was carried out using broth microdilution and checkerboards methods. Activity of α-mangostin paired with an antibiotic was studied by calculating its fracti...

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Main Authors:	Syed Ibrahim, Nurul Huda, Bakhtiar, M. Taher, Darnis, Deny Susanti, Mohamed Amiroudine, Mohamed Zaffar Ali, Ahmed, Qamar Uddin
Format:	Article
Language:	English
Published:	Coastal Life Medicine Media co., Limited 2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/33985/ http://irep.iium.edu.my/33985/ http://irep.iium.edu.my/33985/1/JCLM_mangostin_direct_and_indirect.pdf

id	iium-33985
recordtype	eprints
spelling	iium-339852015-01-29T08:23:58Z http://irep.iium.edu.my/33985/ Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms Syed Ibrahim, Nurul Huda Bakhtiar, M. Taher Darnis, Deny Susanti Mohamed Amiroudine, Mohamed Zaffar Ali Ahmed, Qamar Uddin RS Pharmacy and materia medica Objective: To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and fungi. Methods: The experiment was carried out using broth microdilution and checkerboards methods. Activity of α-mangostin paired with an antibiotic was studied by calculating its fractional inhibitory concentration (FIC). Results: The activity of all four bacteria towards ampicillin, penicillin G, streptomycin and tetracycline showed no interaction with the combination with α-mangostin where the FIC indexes were between the range of 0.5<FICindex>4. Activity of doxycycline on Pseudomonas aeruginosa fell into other set of range, FICindex≥4 which is an antagonism. Conclusions: The FIC index is far away in the range. The coupled antibiotic and α-mangostin is considered synergy in action if it lies in FICindex≤0.5 and it was found that the isolated compound, α-mangostin revealed very low synergistic antimicrobial effects when coupled with antibiotics. Coastal Life Medicine Media co., Limited 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/33985/1/JCLM_mangostin_direct_and_indirect.pdf Syed Ibrahim, Nurul Huda and Bakhtiar, M. Taher and Darnis, Deny Susanti and Mohamed Amiroudine, Mohamed Zaffar Ali and Ahmed, Qamar Uddin (2014) Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms. Journal of Coastal Life Medicine, 2 (1). pp. 70-75. ISSN 2309-6152 (O), 2309-5288 (P) doi:10.12980/JCLM.2.2014J7
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Syed Ibrahim, Nurul Huda Bakhtiar, M. Taher Darnis, Deny Susanti Mohamed Amiroudine, Mohamed Zaffar Ali Ahmed, Qamar Uddin Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
description	Objective: To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and fungi. Methods: The experiment was carried out using broth microdilution and checkerboards methods. Activity of α-mangostin paired with an antibiotic was studied by calculating its fractional inhibitory concentration (FIC). Results: The activity of all four bacteria towards ampicillin, penicillin G, streptomycin and tetracycline showed no interaction with the combination with α-mangostin where the FIC indexes were between the range of 0.5<FICindex>4. Activity of doxycycline on Pseudomonas aeruginosa fell into other set of range, FICindex≥4 which is an antagonism. Conclusions: The FIC index is far away in the range. The coupled antibiotic and α-mangostin is considered synergy in action if it lies in FICindex≤0.5 and it was found that the isolated compound, α-mangostin revealed very low synergistic antimicrobial effects when coupled with antibiotics.
format	Article
author	Syed Ibrahim, Nurul Huda Bakhtiar, M. Taher Darnis, Deny Susanti Mohamed Amiroudine, Mohamed Zaffar Ali Ahmed, Qamar Uddin
author_facet	Syed Ibrahim, Nurul Huda Bakhtiar, M. Taher Darnis, Deny Susanti Mohamed Amiroudine, Mohamed Zaffar Ali Ahmed, Qamar Uddin
author_sort	Syed Ibrahim, Nurul Huda
title	Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
title_short	Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
title_full	Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
title_fullStr	Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
title_full_unstemmed	Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
title_sort	direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
publisher	Coastal Life Medicine Media co., Limited
publishDate	2014
url	http://irep.iium.edu.my/33985/ http://irep.iium.edu.my/33985/ http://irep.iium.edu.my/33985/1/JCLM_mangostin_direct_and_indirect.pdf
first_indexed	2023-09-18T20:49:04Z
last_indexed	2023-09-18T20:49:04Z
_version_	1777409871591768064

Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms

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