In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats

The developmental effects of in-utero administration of the crude ethanolic extract of the leaves of itragyna speciosa (MS) on neural tube in fetal rats were investigated. Pregnant Sprague-Dawley rats were dosed orally once daily by gavage, with graded (500, 1000 and 1500 mg/kg) doses of the extract...

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Main Authors:	Muhammad, Bala Yauri, Abdullahi, Abubakar Danjuma, Abd Kadir, Siti Nur Sharida, Abdul Razak, Tariq, Ahmed, Qamar Uddin
Format:	Article
Language:	English
Published:	Society of Applied Sciences 2010
Subjects:	QM Human anatomy
Online Access:	http://irep.iium.edu.my/340/ http://irep.iium.edu.my/340/ http://irep.iium.edu.my/340/1/In_utero_effect_of_MS_on_Neural_Tube_Formation_in_Rats.pdf

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spelling	iium-3402012-01-31T08:04:12Z http://irep.iium.edu.my/340/ In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats Muhammad, Bala Yauri Abdullahi, Abubakar Danjuma Abd Kadir, Siti Nur Sharida Abdul Razak, Tariq Ahmed, Qamar Uddin QM Human anatomy The developmental effects of in-utero administration of the crude ethanolic extract of the leaves of itragyna speciosa (MS) on neural tube in fetal rats were investigated. Pregnant Sprague-Dawley rats were dosed orally once daily by gavage, with graded (500, 1000 and 1500 mg/kg) doses of the extract between the 8th and 13th day prenatally. The control group received corn oil used as vehicle for the extract. On the 18th day of gestation, mothers were sacrificed and embryos removed and stained under established procedures. The embryos were then analyzed for the presence of neural tube defects (NTD) through measurements of the extent of vertebral arch closure and brain size. Results indicate that the medium (C) and high (D) (1000 & 1500mg/kg) doses but not the low (B) (500mg/kg) dose in comparison with control (A) group, significantly (p10.001) produced a widening of the vertebral arch in the thoracic, lumber and cervical regions of the spinal cord. The brain transverse diameter was also significantly (p10.05) increased by the high dose only. These effects were seen in the absence of any significant differences in litter size and other gross physical abnormalities. This study indicates that the crude extract of the leaves of MS is capable of selective neurotoxicity and producing spina bifida like NTD as characterized by altered brain size and neural tube formation, a finding that may have an important implication in the dependence liability associated with its use. Society of Applied Sciences 2010-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/340/1/In_utero_effect_of_MS_on_Neural_Tube_Formation_in_Rats.pdf Muhammad, Bala Yauri and Abdullahi, Abubakar Danjuma and Abd Kadir, Siti Nur Sharida and Abdul Razak, Tariq and Ahmed, Qamar Uddin (2010) In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats. Asian Journal of Experimental Biological Sciences, 1 (2). pp. 404-408. ISSN 0975-5845 http://www.ajebs.com/about_us.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QM Human anatomy
spellingShingle	QM Human anatomy Muhammad, Bala Yauri Abdullahi, Abubakar Danjuma Abd Kadir, Siti Nur Sharida Abdul Razak, Tariq Ahmed, Qamar Uddin In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats
description	The developmental effects of in-utero administration of the crude ethanolic extract of the leaves of itragyna speciosa (MS) on neural tube in fetal rats were investigated. Pregnant Sprague-Dawley rats were dosed orally once daily by gavage, with graded (500, 1000 and 1500 mg/kg) doses of the extract between the 8th and 13th day prenatally. The control group received corn oil used as vehicle for the extract. On the 18th day of gestation, mothers were sacrificed and embryos removed and stained under established procedures. The embryos were then analyzed for the presence of neural tube defects (NTD) through measurements of the extent of vertebral arch closure and brain size. Results indicate that the medium (C) and high (D) (1000 & 1500mg/kg) doses but not the low (B) (500mg/kg) dose in comparison with control (A) group, significantly (p10.001) produced a widening of the vertebral arch in the thoracic, lumber and cervical regions of the spinal cord. The brain transverse diameter was also significantly (p10.05) increased by the high dose only. These effects were seen in the absence of any significant differences in litter size and other gross physical abnormalities. This study indicates that the crude extract of the leaves of MS is capable of selective neurotoxicity and producing spina bifida like NTD as characterized by altered brain size and neural tube formation, a finding that may have an important implication in the dependence liability associated with its use.
format	Article
author	Muhammad, Bala Yauri Abdullahi, Abubakar Danjuma Abd Kadir, Siti Nur Sharida Abdul Razak, Tariq Ahmed, Qamar Uddin
author_facet	Muhammad, Bala Yauri Abdullahi, Abubakar Danjuma Abd Kadir, Siti Nur Sharida Abdul Razak, Tariq Ahmed, Qamar Uddin
author_sort	Muhammad, Bala Yauri
title	In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats
title_short	In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats
title_full	In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats
title_fullStr	In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats
title_full_unstemmed	In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats
title_sort	in-utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats
publisher	Society of Applied Sciences
publishDate	2010
url	http://irep.iium.edu.my/340/ http://irep.iium.edu.my/340/ http://irep.iium.edu.my/340/1/In_utero_effect_of_MS_on_Neural_Tube_Formation_in_Rats.pdf
first_indexed	2023-09-18T20:07:27Z
last_indexed	2023-09-18T20:07:27Z
_version_	1777407253946564608

In-Utero effects of the crude ethanolic extract of the leaves of mitragyna speciosa on neural tube formation in rats

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