Mesenchymal stem cell therapy for injured growth plate

The growth plate has a limited self-healing capacity. Fractures sustained to the growth plate of young children could cause growth disturbances like angular deformity or growth arrest. Established therapies for injured physis only address related complications. Mesenchymal stem cells (MSCs) are mult...

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Main Authors:	Awang, Mohd Shukrimi, Mohd, Afizah, Jacqueline F , Schmitt, James, Hui
Format:	Article
Language:	English English
Published:	Frontiers in Bioscience 2013
Subjects:	RJ Pediatrics
Online Access:	http://irep.iium.edu.my/34237/ http://irep.iium.edu.my/34237/ http://irep.iium.edu.my/34237/ http://irep.iium.edu.my/34237/1/Frontiers_in_Bioscience_S5-article.docx http://irep.iium.edu.my/34237/2/Mesenchymal_stem_cell_therapy_for_injured_growth_plate.pdf

id	iium-34237
recordtype	eprints
spelling	iium-342372014-01-16T09:30:52Z http://irep.iium.edu.my/34237/ Mesenchymal stem cell therapy for injured growth plate Awang, Mohd Shukrimi Mohd, Afizah Jacqueline F , Schmitt James, Hui RJ Pediatrics The growth plate has a limited self-healing capacity. Fractures sustained to the growth plate of young children could cause growth disturbances like angular deformity or growth arrest. Established therapies for injured physis only address related complications. Mesenchymal stem cells (MSCs) are multipotent cells which are capable of differentiating into various cells of the musculoskeletal system. Various MSC types have been tested for physeal regeneration, through in vivo lapine, porcine and ovine models, for the duration of 4-16 weeks. The created defect sizes ranged from 7-50% of the growth plate area, to simulate clinically-encountered cases. In vitro models have also been investigated, as a means to screen potential treatments. The effects of MSCs gathered from these models have revealed its function in the prevention of bone bridge formation, with the subsequent development of organized physeal repair tissue. Possible influential factors like the number of implanted MSCs, preconditioned state, growth factors, chondrocyte-MSC interaction and scaffolds are discussed. Possible further studies to optimize physeal repair based on MSC therapy in articular cartilage are also included. Frontiers in Bioscience 2013-01-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/34237/1/Frontiers_in_Bioscience_S5-article.docx application/pdf en http://irep.iium.edu.my/34237/2/Mesenchymal_stem_cell_therapy_for_injured_growth_plate.pdf Awang, Mohd Shukrimi and Mohd, Afizah and Jacqueline F , Schmitt and James, Hui (2013) Mesenchymal stem cell therapy for injured growth plate. Frontiers in Bioscience Scholar Edition, S5 (3). pp. 774-785. ISSN 1945-0516 http://www.bioscience.org/2013/v5s/af/407/3.htm http://dx.doi.org/10.2741/S407
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RJ Pediatrics
spellingShingle	RJ Pediatrics Awang, Mohd Shukrimi Mohd, Afizah Jacqueline F , Schmitt James, Hui Mesenchymal stem cell therapy for injured growth plate
description	The growth plate has a limited self-healing capacity. Fractures sustained to the growth plate of young children could cause growth disturbances like angular deformity or growth arrest. Established therapies for injured physis only address related complications. Mesenchymal stem cells (MSCs) are multipotent cells which are capable of differentiating into various cells of the musculoskeletal system. Various MSC types have been tested for physeal regeneration, through in vivo lapine, porcine and ovine models, for the duration of 4-16 weeks. The created defect sizes ranged from 7-50% of the growth plate area, to simulate clinically-encountered cases. In vitro models have also been investigated, as a means to screen potential treatments. The effects of MSCs gathered from these models have revealed its function in the prevention of bone bridge formation, with the subsequent development of organized physeal repair tissue. Possible influential factors like the number of implanted MSCs, preconditioned state, growth factors, chondrocyte-MSC interaction and scaffolds are discussed. Possible further studies to optimize physeal repair based on MSC therapy in articular cartilage are also included.
format	Article
author	Awang, Mohd Shukrimi Mohd, Afizah Jacqueline F , Schmitt James, Hui
author_facet	Awang, Mohd Shukrimi Mohd, Afizah Jacqueline F , Schmitt James, Hui
author_sort	Awang, Mohd Shukrimi
title	Mesenchymal stem cell therapy for injured growth plate
title_short	Mesenchymal stem cell therapy for injured growth plate
title_full	Mesenchymal stem cell therapy for injured growth plate
title_fullStr	Mesenchymal stem cell therapy for injured growth plate
title_full_unstemmed	Mesenchymal stem cell therapy for injured growth plate
title_sort	mesenchymal stem cell therapy for injured growth plate
publisher	Frontiers in Bioscience
publishDate	2013
url	http://irep.iium.edu.my/34237/ http://irep.iium.edu.my/34237/ http://irep.iium.edu.my/34237/ http://irep.iium.edu.my/34237/1/Frontiers_in_Bioscience_S5-article.docx http://irep.iium.edu.my/34237/2/Mesenchymal_stem_cell_therapy_for_injured_growth_plate.pdf
first_indexed	2023-09-18T20:49:23Z
last_indexed	2023-09-18T20:49:23Z
_version_	1777409891984474112

Mesenchymal stem cell therapy for injured growth plate

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