Genetic and bio-chemical determinants of dementia

As the neurodegenerative disease (NDD), dementia, is emerging as a silent epidemic for rapidly developing countries like Malaysia, locally investigation of its prevalence including genetic, biochemical and behavioural determinants were the focused objective of this study. For clinical epidemiologica...

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Main Authors:	Akter, Seikh Farid Uddin, Abdul Rani, Mohammed Fauzi, Nordin, Mohamad Sahari, Khattak, Muhammad Muzaffar Ali Khan, Md Aris, Mohd Aznan, Bakhtiar, M. Taher
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/34289/ http://irep.iium.edu.my/34289/1/Dementia.pdf

id	iium-34289
recordtype	eprints
spelling	iium-342892014-12-09T01:01:02Z http://irep.iium.edu.my/34289/ Genetic and bio-chemical determinants of dementia Akter, Seikh Farid Uddin Abdul Rani, Mohammed Fauzi Nordin, Mohamad Sahari Khattak, Muhammad Muzaffar Ali Khan Md Aris, Mohd Aznan Bakhtiar, M. Taher R Medicine (General) As the neurodegenerative disease (NDD), dementia, is emerging as a silent epidemic for rapidly developing countries like Malaysia, locally investigation of its prevalence including genetic, biochemical and behavioural determinants were the focused objective of this study. For clinical epidemiological investigation of dementia, the commonest NND, an initial descriptive study to assess the magnitude of dementia followed by a case-control study were conducted in collaboration with other higher educational institutions both overseas and in Malaysia. This study revealed many facts locally unexplored previously. Data were collected from a statistical sound sample size (197 study subjects initially for the descriptive phase; 63 dementia cases and 103 age matched controls for analytic phase) using a questionnaire for personal profile and other related factors. The standard protocols were followed to measure the selected biochemical determinants such as adiponectin, glucose levels, lipid profile and alleles of apolipoprotein E gene (APOE). The statistical analyses were performed using standard statistical software, the SPSS (Statistical Package for the Social Sciences) for Windows, Version 17. In addition to descriptive statistics, pertinent inferential statistical analyses were performed. It appears from the initial descriptive study that dementia was the leading diseases (72.1%) of the identified neurodegenerative diseases among study subjects. In investigation of genetic determinant, as in other areas of inquiry, one-fifth (19.7%) of the identified cases revealed the positive family history reflecting the putative role for inherited susceptibility. About one-third of them were smokers (29.4%). Among the known co-morbidities, type 2 diabetes mellitus, hyperlipidemia and hypertension were remarkable (43.7%, 11.3% and 65.5% respectively). The evident of high percentages of patients were suffering from different co-morbidities in combinations suggested the potential scope for further investigations of selected biochemical and genetic determinants such as, serum adiponectin level, lipid profile and glycaemic status and alleles (ApoE-ε2 Apo ApoE-ε3 and E-ε4) of APOE to explore the respective etiological role. ApoE-ε4 was statistically significantly associated with dementia (¬2 (df = 1) = 10.8, p<0.01) and might be an important determinant for the dementia cases. The proportion of dementia cases among neurodegenerative diseases in this study was alarmingly high. Type 2 diabetes mellitus was the most common co-morbidity and ApoE-ε4 appears to be a genetic determinant of dementia. 2013 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/34289/1/Dementia.pdf Akter, Seikh Farid Uddin and Abdul Rani, Mohammed Fauzi and Nordin, Mohamad Sahari and Khattak, Muhammad Muzaffar Ali Khan and Md Aris, Mohd Aznan and Bakhtiar, M. Taher (2013) Genetic and bio-chemical determinants of dementia. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2013, 19-20 February 2013, Kuala Lumpur, Malaysia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Akter, Seikh Farid Uddin Abdul Rani, Mohammed Fauzi Nordin, Mohamad Sahari Khattak, Muhammad Muzaffar Ali Khan Md Aris, Mohd Aznan Bakhtiar, M. Taher Genetic and bio-chemical determinants of dementia
description	As the neurodegenerative disease (NDD), dementia, is emerging as a silent epidemic for rapidly developing countries like Malaysia, locally investigation of its prevalence including genetic, biochemical and behavioural determinants were the focused objective of this study. For clinical epidemiological investigation of dementia, the commonest NND, an initial descriptive study to assess the magnitude of dementia followed by a case-control study were conducted in collaboration with other higher educational institutions both overseas and in Malaysia. This study revealed many facts locally unexplored previously. Data were collected from a statistical sound sample size (197 study subjects initially for the descriptive phase; 63 dementia cases and 103 age matched controls for analytic phase) using a questionnaire for personal profile and other related factors. The standard protocols were followed to measure the selected biochemical determinants such as adiponectin, glucose levels, lipid profile and alleles of apolipoprotein E gene (APOE). The statistical analyses were performed using standard statistical software, the SPSS (Statistical Package for the Social Sciences) for Windows, Version 17. In addition to descriptive statistics, pertinent inferential statistical analyses were performed. It appears from the initial descriptive study that dementia was the leading diseases (72.1%) of the identified neurodegenerative diseases among study subjects. In investigation of genetic determinant, as in other areas of inquiry, one-fifth (19.7%) of the identified cases revealed the positive family history reflecting the putative role for inherited susceptibility. About one-third of them were smokers (29.4%). Among the known co-morbidities, type 2 diabetes mellitus, hyperlipidemia and hypertension were remarkable (43.7%, 11.3% and 65.5% respectively). The evident of high percentages of patients were suffering from different co-morbidities in combinations suggested the potential scope for further investigations of selected biochemical and genetic determinants such as, serum adiponectin level, lipid profile and glycaemic status and alleles (ApoE-ε2 Apo ApoE-ε3 and E-ε4) of APOE to explore the respective etiological role. ApoE-ε4 was statistically significantly associated with dementia (¬2 (df = 1) = 10.8, p<0.01) and might be an important determinant for the dementia cases. The proportion of dementia cases among neurodegenerative diseases in this study was alarmingly high. Type 2 diabetes mellitus was the most common co-morbidity and ApoE-ε4 appears to be a genetic determinant of dementia.
format	Conference or Workshop Item
author	Akter, Seikh Farid Uddin Abdul Rani, Mohammed Fauzi Nordin, Mohamad Sahari Khattak, Muhammad Muzaffar Ali Khan Md Aris, Mohd Aznan Bakhtiar, M. Taher
author_facet	Akter, Seikh Farid Uddin Abdul Rani, Mohammed Fauzi Nordin, Mohamad Sahari Khattak, Muhammad Muzaffar Ali Khan Md Aris, Mohd Aznan Bakhtiar, M. Taher
author_sort	Akter, Seikh Farid Uddin
title	Genetic and bio-chemical determinants of dementia
title_short	Genetic and bio-chemical determinants of dementia
title_full	Genetic and bio-chemical determinants of dementia
title_fullStr	Genetic and bio-chemical determinants of dementia
title_full_unstemmed	Genetic and bio-chemical determinants of dementia
title_sort	genetic and bio-chemical determinants of dementia
publishDate	2013
url	http://irep.iium.edu.my/34289/ http://irep.iium.edu.my/34289/1/Dementia.pdf
first_indexed	2023-09-18T20:49:27Z
last_indexed	2023-09-18T20:49:27Z
_version_	1777409896055046144

Genetic and bio-chemical determinants of dementia

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