Preparation of metformin HCl microspheres and encapsulation efficiency

Due to the pharmacokinetic properties, metformin HCl needs longer period to achieve therapeutic effects with multiple daily doses which may reduce patient’s adherence towards the medication. Hence, novel drug delivery system such as microspheres may be helpful for this non-compliance of the conventi...

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Main Authors:	Ahmad, Kausar, Ruslan, Ruhaini, Mohamed, Farahidah, Elsaid Ali, Aimen Abdo
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/34545/ http://irep.iium.edu.my/34545/4/Exhibition_PECIPTA2013_kausar20151006.pdf

id	iium-34545
recordtype	eprints
spelling	iium-345452015-10-22T07:16:14Z http://irep.iium.edu.my/34545/ Preparation of metformin HCl microspheres and encapsulation efficiency Ahmad, Kausar Ruslan, Ruhaini Mohamed, Farahidah Elsaid Ali, Aimen Abdo RS Pharmacy and materia medica Due to the pharmacokinetic properties, metformin HCl needs longer period to achieve therapeutic effects with multiple daily doses which may reduce patient’s adherence towards the medication. Hence, novel drug delivery system such as microspheres may be helpful for this non-compliance of the conventional therapy. Double-emulsion solvent evaporation technique was employed in this work since Metformin HCl is a hydrophilic drug. PLGA and PVA of specific characteristics were used. A total of 30 formulations were prepared by varying the concentration of metformin and different conditions. The procedure employed resulted in spherical and free-flowing microspheres with acceptable particle size for drug delivery. Maximum encapsulation efficiency observed was 15%. The concentration of metformin used influenced the encapsulation efficiency among other factors. Higher values, which is desirable for dosage form, may be obtained by manipulating the parameters such as the molecular weight of PLGA. 2013-12-07 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/34545/4/Exhibition_PECIPTA2013_kausar20151006.pdf Ahmad, Kausar and Ruslan, Ruhaini and Mohamed, Farahidah and Elsaid Ali, Aimen Abdo (2013) Preparation of metformin HCl microspheres and encapsulation efficiency. In: International Conference and Exposition of Invention on Institutions of Higher Learning (PECIPTA 2013), 7th-9th Dec. 2013, Kuala Lumpur Convention Center (KLCC), Kuala Lumpur.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ahmad, Kausar Ruslan, Ruhaini Mohamed, Farahidah Elsaid Ali, Aimen Abdo Preparation of metformin HCl microspheres and encapsulation efficiency
description	Due to the pharmacokinetic properties, metformin HCl needs longer period to achieve therapeutic effects with multiple daily doses which may reduce patient’s adherence towards the medication. Hence, novel drug delivery system such as microspheres may be helpful for this non-compliance of the conventional therapy. Double-emulsion solvent evaporation technique was employed in this work since Metformin HCl is a hydrophilic drug. PLGA and PVA of specific characteristics were used. A total of 30 formulations were prepared by varying the concentration of metformin and different conditions. The procedure employed resulted in spherical and free-flowing microspheres with acceptable particle size for drug delivery. Maximum encapsulation efficiency observed was 15%. The concentration of metformin used influenced the encapsulation efficiency among other factors. Higher values, which is desirable for dosage form, may be obtained by manipulating the parameters such as the molecular weight of PLGA.
format	Conference or Workshop Item
author	Ahmad, Kausar Ruslan, Ruhaini Mohamed, Farahidah Elsaid Ali, Aimen Abdo
author_facet	Ahmad, Kausar Ruslan, Ruhaini Mohamed, Farahidah Elsaid Ali, Aimen Abdo
author_sort	Ahmad, Kausar
title	Preparation of metformin HCl microspheres and encapsulation efficiency
title_short	Preparation of metformin HCl microspheres and encapsulation efficiency
title_full	Preparation of metformin HCl microspheres and encapsulation efficiency
title_fullStr	Preparation of metformin HCl microspheres and encapsulation efficiency
title_full_unstemmed	Preparation of metformin HCl microspheres and encapsulation efficiency
title_sort	preparation of metformin hcl microspheres and encapsulation efficiency
publishDate	2013
url	http://irep.iium.edu.my/34545/ http://irep.iium.edu.my/34545/4/Exhibition_PECIPTA2013_kausar20151006.pdf
first_indexed	2023-09-18T20:49:46Z
last_indexed	2023-09-18T20:49:46Z
_version_	1777409915646640128

Preparation of metformin HCl microspheres and encapsulation efficiency

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