Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.
Introduction: The study was done at the aim to assess the functionality and viability of the β cells of the streptozotocin-induced diabetic rats model following repetitive dosage of administration of ethanolic extracts of Andrographis paniculata. Materials and Methods: The diabetic rats were treated...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine, International Islamic University Malaysia
2010
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/347/ http://irep.iium.edu.my/347/ http://irep.iium.edu.my/347/1/Assessment_on_functionality_and_viability_of_b_cells_%281%29.pdf |
| Summary: | Introduction: The study was done at the aim to assess the functionality and viability of the β cells of the streptozotocin-induced diabetic rats model following repetitive dosage of administration of ethanolic extracts of Andrographis paniculata. Materials and Methods: The diabetic rats were treated with the extracts for fourteen days and at the dose given was 500 mg/kg twice daily. The assessments were made on fasting blood glucose, insulin, and immunohistochemical aspect of β cells before and after treatment.
Results: The results showed that there was a signifi cant reduction on fasting blood glucose levels in metformin, 95% and 50% ethanolic plant extracts-treated groups but on insulin level only 95% and 50% ethanolic extracts-treated
groups gave a signifi cant reduction (p<0.05). Immunohistochemical assessments revealed that all extract
groups and metformin-treated were signifi cantly increased in the population of β cells (p<0.01).
Conclusion: This study revealed that the plant extracts showed an ability to promote the growth or rejuvenate the STZdestructed β cells and in turn lower the blood glucose level. |
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