Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.

Introduction: The study was done at the aim to assess the functionality and viability of the β cells of the streptozotocin-induced diabetic rats model following repetitive dosage of administration of ethanolic extracts of Andrographis paniculata. Materials and Methods: The diabetic rats were treated...

Full description

Bibliographic Details
Main Authors:	Kasmuri, Abdul Razak, Ahmad, Mariam, Sadikun, Amirin, Asmawi, Mohd Zaini
Format:	Article
Language:	English
Published:	Faculty of Medicine, International Islamic University Malaysia 2010
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/347/ http://irep.iium.edu.my/347/ http://irep.iium.edu.my/347/1/Assessment_on_functionality_and_viability_of_b_cells_%281%29.pdf

id	iium-347
recordtype	eprints
spelling	iium-3472019-01-24T08:23:06Z http://irep.iium.edu.my/347/ Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. Kasmuri, Abdul Razak Ahmad, Mariam Sadikun, Amirin Asmawi, Mohd Zaini RS Pharmacy and materia medica Introduction: The study was done at the aim to assess the functionality and viability of the β cells of the streptozotocin-induced diabetic rats model following repetitive dosage of administration of ethanolic extracts of Andrographis paniculata. Materials and Methods: The diabetic rats were treated with the extracts for fourteen days and at the dose given was 500 mg/kg twice daily. The assessments were made on fasting blood glucose, insulin, and immunohistochemical aspect of β cells before and after treatment. Results: The results showed that there was a signifi cant reduction on fasting blood glucose levels in metformin, 95% and 50% ethanolic plant extracts-treated groups but on insulin level only 95% and 50% ethanolic extracts-treated groups gave a signifi cant reduction (p<0.05). Immunohistochemical assessments revealed that all extract groups and metformin-treated were signifi cantly increased in the population of β cells (p<0.01). Conclusion: This study revealed that the plant extracts showed an ability to promote the growth or rejuvenate the STZdestructed β cells and in turn lower the blood glucose level. Faculty of Medicine, International Islamic University Malaysia 2010-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/347/1/Assessment_on_functionality_and_viability_of_b_cells_%281%29.pdf Kasmuri, Abdul Razak and Ahmad, Mariam and Sadikun, Amirin and Asmawi, Mohd Zaini (2010) Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. International Medical Journal Malaysia, 9 (1). pp. 21-26. ISSN 1823-4631 http://iiumedic.com/eimj/v1/?p=149
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Kasmuri, Abdul Razak Ahmad, Mariam Sadikun, Amirin Asmawi, Mohd Zaini Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.
description	Introduction: The study was done at the aim to assess the functionality and viability of the β cells of the streptozotocin-induced diabetic rats model following repetitive dosage of administration of ethanolic extracts of Andrographis paniculata. Materials and Methods: The diabetic rats were treated with the extracts for fourteen days and at the dose given was 500 mg/kg twice daily. The assessments were made on fasting blood glucose, insulin, and immunohistochemical aspect of β cells before and after treatment. Results: The results showed that there was a signifi cant reduction on fasting blood glucose levels in metformin, 95% and 50% ethanolic plant extracts-treated groups but on insulin level only 95% and 50% ethanolic extracts-treated groups gave a signifi cant reduction (p<0.05). Immunohistochemical assessments revealed that all extract groups and metformin-treated were signifi cantly increased in the population of β cells (p<0.01). Conclusion: This study revealed that the plant extracts showed an ability to promote the growth or rejuvenate the STZdestructed β cells and in turn lower the blood glucose level.
format	Article
author	Kasmuri, Abdul Razak Ahmad, Mariam Sadikun, Amirin Asmawi, Mohd Zaini
author_facet	Kasmuri, Abdul Razak Ahmad, Mariam Sadikun, Amirin Asmawi, Mohd Zaini
author_sort	Kasmuri, Abdul Razak
title	Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.
title_short	Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.
title_full	Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.
title_fullStr	Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.
title_full_unstemmed	Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.
title_sort	assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.
publisher	Faculty of Medicine, International Islamic University Malaysia
publishDate	2010
url	http://irep.iium.edu.my/347/ http://irep.iium.edu.my/347/ http://irep.iium.edu.my/347/1/Assessment_on_functionality_and_viability_of_b_cells_%281%29.pdf
first_indexed	2023-09-18T20:07:28Z
last_indexed	2023-09-18T20:07:28Z
_version_	1777407254392209408

Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.

Similar Items