Perinatal programming of hypertension on exposure to high and low sodium chloride diet during pregnancy and lactation in Sprague-Dawley rats
Background: Adverse conditions in utero may lead to hypertension during in later life, however inconsistency of the result has been reported. Objective: This experiment aims at studying the effects of high and low maternal dietary sodium on their offspring’s blood pressure at 4 and 8...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/34805/ http://irep.iium.edu.my/34805/ http://irep.iium.edu.my/34805/2/PERINATAL_PROGRAMMING_2014_MSH.pdf |
| Summary: | Background:
Adverse conditions in utero may lead to hypertension during in later life, however inconsistency of the result has been reported.
Objective:
This experiment aims at studying the effects of high and low maternal dietary sodium on their offspring’s blood pressure at 4 and 8 weeks.
Materials and methods:
Normotensive female rats were subjected to timed pregnancy. Pregnant rats were randomly divided into three groups and were fed either low-sodium diet (LSD) (0.145%NaCl) (n=10),
normal-sodium diet (NSD) (1.0%NaCl) (n=10) or high-sodium diet (HSD) (3.0%NaCl)(n=10) during pregnancy and 4 weeks of lactation. The offsprings were weaned at 4 weeks old. Thereafter, all the three groups were fed with normal-sodium diet (1.0%NaCl) for another 4 weeks.
Results:
At 4 weeks old, the offsprings of HSD dams have significantly higher systolic blood pressure(SBP) compared to NSD group respectively (119.44mmHg ±1.8 vs 103.65mmHg ±0.92). There were no differences in the offspring’s SBP between NSD and LSD dams at 4 weeks old.
Nevertheless, at 8 weeks old, the offspring’s of LSD dams have significantly higher SBP as compared to NSD dams (130.13±1.45mmHg vs 120.26mmHg±1.09). Similarly, at 8 weeks old, the offspring of HSD dams have significantly higher SBP as compared to NSD dams 131.06±1.49mmHg vs 120.26mmHg±1.09). The offspring’s heart rate, average food intake and body weight were similar between all the three groups at 4 and 8 weeks.
Conclusions:
This suggests that the offspring of both HSD and LSD have greater propensity to develop higher blood pressure and it is pertinent to consider optimum dietary sodium consumption during.
pregnancy. |
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