A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm

Concurrent use of cocaine and heroin is a major public health issue with no effective relapse prevention treatment currently available. To this purpose, a combination of buprenorphine and naltrexone, a mixed very-low efficacy mu-opioid receptor agonist/kappa-opioid receptor antagonist/nociceptin rec...

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Main Authors:	Cordery, Sarah F, Taverner, Alistair, Ridzwan, Irna Elina, Guy, Richard H, Delgado-Charro, M Begoña, Husbands, Stephen M, Bailey, Christopher P
Format:	Article
Language:	English
Published:	Wiley 2014
Subjects:	RM300 Drugs and their action RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/35174/ http://irep.iium.edu.my/35174/ http://irep.iium.edu.my/35174/1/35174.pdf

id	iium-35174
recordtype	eprints
spelling	iium-351742018-08-08T04:19:21Z http://irep.iium.edu.my/35174/ A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm Cordery, Sarah F Taverner, Alistair Ridzwan, Irna Elina Guy, Richard H Delgado-Charro, M Begoña Husbands, Stephen M Bailey, Christopher P RM300 Drugs and their action RS Pharmacy and materia medica Concurrent use of cocaine and heroin is a major public health issue with no effective relapse prevention treatment currently available. To this purpose, a combination of buprenorphine and naltrexone, a mixed very-low efficacy mu-opioid receptor agonist/kappa-opioid receptor antagonist/nociceptin receptor agonist, was investigated. The tail-withdrawal and the conditioned place preference (CPP) assays in adult Sprague Dawley rats were used to show that naltrexone dose-dependently blocked the mu-opioid receptor agonism of buprenorphine. Furthermore, in the CPP assay, a combination of 0.3 mg/kg buprenorphine and 3.0 mg/kg naltrexone was aversive. A combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone was neither rewarding nor aversive, but still possessed mu-opioid receptor antagonist properties. In the CPP extinction and reinstatement method, a combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone completely blocked drug-primed reinstatement in cocaine-conditioned rats (conditioned with 3 mg/kg cocaine, drug prime was 3 mg/kg cocaine) and attenuated drug-primed reinstatement in morphine-conditioned rats (conditioned with 5 mg/kg morphine, drug prime was 1.25 mg/kg morphine). These data add to the growing evidence that a buprenorphine/naltrexone combination may be protective against relapse in a polydrug abuse situation. Wiley 2014-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/35174/1/35174.pdf Cordery, Sarah F and Taverner, Alistair and Ridzwan, Irna Elina and Guy, Richard H and Delgado-Charro, M Begoña and Husbands, Stephen M and Bailey, Christopher P (2014) A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm. Addiction Biology, 19 (4). pp. 575-586. ISSN 1355-6215 E-ISSN 1369-1600 https://onlinelibrary.wiley.com/toc/13691600/2014/19/4
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM300 Drugs and their action RS Pharmacy and materia medica
spellingShingle	RM300 Drugs and their action RS Pharmacy and materia medica Cordery, Sarah F Taverner, Alistair Ridzwan, Irna Elina Guy, Richard H Delgado-Charro, M Begoña Husbands, Stephen M Bailey, Christopher P A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
description	Concurrent use of cocaine and heroin is a major public health issue with no effective relapse prevention treatment currently available. To this purpose, a combination of buprenorphine and naltrexone, a mixed very-low efficacy mu-opioid receptor agonist/kappa-opioid receptor antagonist/nociceptin receptor agonist, was investigated. The tail-withdrawal and the conditioned place preference (CPP) assays in adult Sprague Dawley rats were used to show that naltrexone dose-dependently blocked the mu-opioid receptor agonism of buprenorphine. Furthermore, in the CPP assay, a combination of 0.3 mg/kg buprenorphine and 3.0 mg/kg naltrexone was aversive. A combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone was neither rewarding nor aversive, but still possessed mu-opioid receptor antagonist properties. In the CPP extinction and reinstatement method, a combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone completely blocked drug-primed reinstatement in cocaine-conditioned rats (conditioned with 3 mg/kg cocaine, drug prime was 3 mg/kg cocaine) and attenuated drug-primed reinstatement in morphine-conditioned rats (conditioned with 5 mg/kg morphine, drug prime was 1.25 mg/kg morphine). These data add to the growing evidence that a buprenorphine/naltrexone combination may be protective against relapse in a polydrug abuse situation.
format	Article
author	Cordery, Sarah F Taverner, Alistair Ridzwan, Irna Elina Guy, Richard H Delgado-Charro, M Begoña Husbands, Stephen M Bailey, Christopher P
author_facet	Cordery, Sarah F Taverner, Alistair Ridzwan, Irna Elina Guy, Richard H Delgado-Charro, M Begoña Husbands, Stephen M Bailey, Christopher P
author_sort	Cordery, Sarah F
title	A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
title_short	A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
title_full	A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
title_fullStr	A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
title_full_unstemmed	A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
title_sort	non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
publisher	Wiley
publishDate	2014
url	http://irep.iium.edu.my/35174/ http://irep.iium.edu.my/35174/ http://irep.iium.edu.my/35174/1/35174.pdf
first_indexed	2023-09-18T20:50:30Z
last_indexed	2023-09-18T20:50:30Z
_version_	1777409962504355840

A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm

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