Structures and hydrogen bonding recognition of mefenamic acid form I crystals in mefenamic acid/ethanol solution
Mefenamic acid is one of the active pharmaceutical ingredients that exhibit polymorphism. An experimental study has found that Form I of mefenamic acid is produced from cooling crystallization with ethanol as a solvent. Hydrogen bonding is considered as the fundamental factor that controls the poly...
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IACSIT Press
2013
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iium-351892014-07-16T01:47:47Z http://irep.iium.edu.my/35189/ Structures and hydrogen bonding recognition of mefenamic acid form I crystals in mefenamic acid/ethanol solution Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Adam, Fatmawati Jamal, Parveen QD Chemistry RS Pharmacy and materia medica TP155 Chemical engineering Mefenamic acid is one of the active pharmaceutical ingredients that exhibit polymorphism. An experimental study has found that Form I of mefenamic acid is produced from cooling crystallization with ethanol as a solvent. Hydrogen bonding is considered as the fundamental factor that controls the polymorphism of mefenamic acid in ethanol. This work, in essence, was performed to verify this using molecular dynamics simulation.The simulation was performed using COMPASS force field available in Material Studio package.The result of the simulation showed strong hydrogen bonding between oxygen and hydrogen in the carboxylic group. The results of the Fourier transform infrared spectroscopy analysis confirmed the existence of O-H, C-O and C=O bonds. These findings proved the presence of hydrogen bonds that leads to the formation of hydrogen motif in Form I of mefenamic acid during crystallization process using ethanol as a solvent. IACSIT Press 2013-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/35189/1/paper_JCEA.pdf Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Adam, Fatmawati and Jamal, Parveen (2013) Structures and hydrogen bonding recognition of mefenamic acid form I crystals in mefenamic acid/ethanol solution. International Journal of Chemical Engineering and Applications, 4 (3). pp. 124-128. ISSN 2010-0221 http://www.ijcea.org/index.php?m=content&c=index&a=show&catid=48&id=574 10.7763/IJCEA.2013.V4.277 |
| repository_type |
Digital Repository |
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Local University |
| institution |
International Islamic University Malaysia |
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IIUM Repository |
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Online Access |
| language |
English |
| topic |
QD Chemistry RS Pharmacy and materia medica TP155 Chemical engineering |
| spellingShingle |
QD Chemistry RS Pharmacy and materia medica TP155 Chemical engineering Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Adam, Fatmawati Jamal, Parveen Structures and hydrogen bonding recognition of mefenamic acid form I crystals in mefenamic acid/ethanol solution |
| description |
Mefenamic acid is one of the active pharmaceutical ingredients that exhibit polymorphism. An experimental study has found that Form I of mefenamic acid is produced from cooling crystallization with ethanol as a solvent.
Hydrogen bonding is considered as the fundamental factor that controls the polymorphism of mefenamic acid in ethanol. This work, in essence, was performed to verify this using molecular dynamics simulation.The simulation was performed using COMPASS force field available in Material Studio package.The result of the simulation showed strong hydrogen bonding between oxygen and hydrogen in the carboxylic group. The results of the Fourier transform infrared spectroscopy analysis confirmed the existence of O-H, C-O and C=O bonds. These findings proved the presence of hydrogen bonds that leads to the formation of hydrogen motif in Form I of mefenamic acid during crystallization process using ethanol as a solvent. |
| format |
Article |
| author |
Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Adam, Fatmawati Jamal, Parveen |
| author_facet |
Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Adam, Fatmawati Jamal, Parveen |
| author_sort |
Abdul Mudalip, Siti Kholijah |
| title |
Structures and hydrogen bonding recognition of mefenamic acid form I crystals in mefenamic acid/ethanol solution |
| title_short |
Structures and hydrogen bonding recognition of mefenamic acid form I crystals in mefenamic acid/ethanol solution |
| title_full |
Structures and hydrogen bonding recognition of mefenamic acid form I crystals in mefenamic acid/ethanol solution |
| title_fullStr |
Structures and hydrogen bonding recognition of mefenamic acid form I crystals in mefenamic acid/ethanol solution |
| title_full_unstemmed |
Structures and hydrogen bonding recognition of mefenamic acid form I crystals in mefenamic acid/ethanol solution |
| title_sort |
structures and hydrogen bonding recognition of mefenamic acid form i crystals in mefenamic acid/ethanol solution |
| publisher |
IACSIT Press |
| publishDate |
2013 |
| url |
http://irep.iium.edu.my/35189/ http://irep.iium.edu.my/35189/ http://irep.iium.edu.my/35189/ http://irep.iium.edu.my/35189/1/paper_JCEA.pdf |
| first_indexed |
2023-09-18T20:50:32Z |
| last_indexed |
2023-09-18T20:50:32Z |
| _version_ |
1777409963663032320 |