Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents

Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents

Different classes of solvents provide different polarity values, which influence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in different classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatur...

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Main Authors: Abdul Mudalip, Siti Kholijah, Abu Bakar, Mohd Rushdi, Adam, Fatmawati, Jamal, Parveen
Format: Article
Language:English
Published: ACS Publications 2013
Subjects:
RS Pharmacy and materia medica
TP155 Chemical engineering
Online Access:http://irep.iium.edu.my/35192/
http://irep.iium.edu.my/35192/
http://irep.iium.edu.my/35192/
http://irep.iium.edu.my/35192/1/Abdul_Mudalip_et_al_2013.pdf
id iium-35192
recordtype eprints
spelling iium-351922016-02-29T02:53:22Z http://irep.iium.edu.my/35192/ Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Adam, Fatmawati Jamal, Parveen RS Pharmacy and materia medica TP155 Chemical engineering Different classes of solvents provide different polarity values, which influence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in different classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures from (298 to 323) K are reported. It has been found that mefenamic acid shows high solubility in dipolar aprotic solvents (N,N-dimethylacetamide, N,N-dimethylformamide, ethyl acetate, and propanone), moderate solubility in polar protic solvents (ethanol and propan-2-ol), and poor solubility in apolar aprotic solvents (hexane, heptane, and cyclohexane) and water. ACS Publications 2013-11-21 Article PeerReviewed application/pdf en http://irep.iium.edu.my/35192/1/Abdul_Mudalip_et_al_2013.pdf Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Adam, Fatmawati and Jamal, Parveen (2013) Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents. Journal of Chemical and Engineering Data, 58. pp. 3447-3452. ISSN 0021-9568 http://pubs.acs.org/journal/jceaax dx.doi.org/10.1021/je400714f |
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RS Pharmacy and materia medica
TP155 Chemical engineering
spellingShingle RS Pharmacy and materia medica
TP155 Chemical engineering
Abdul Mudalip, Siti Kholijah
Abu Bakar, Mohd Rushdi
Adam, Fatmawati
Jamal, Parveen
Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents
description Different classes of solvents provide different polarity values, which influence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in different classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures from (298 to 323) K are reported. It has been found that mefenamic acid shows high solubility in dipolar aprotic solvents (N,N-dimethylacetamide, N,N-dimethylformamide, ethyl acetate, and propanone), moderate solubility in polar protic solvents (ethanol and propan-2-ol), and poor solubility in apolar aprotic solvents (hexane, heptane, and cyclohexane) and water.
format Article
author Abdul Mudalip, Siti Kholijah
Abu Bakar, Mohd Rushdi
Adam, Fatmawati
Jamal, Parveen
author_facet Abdul Mudalip, Siti Kholijah
Abu Bakar, Mohd Rushdi
Adam, Fatmawati
Jamal, Parveen
author_sort Abdul Mudalip, Siti Kholijah
title Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents
title_short Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents
title_full Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents
title_fullStr Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents
title_full_unstemmed Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents
title_sort solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of organic solvents
publisher ACS Publications
publishDate 2013
url http://irep.iium.edu.my/35192/
http://irep.iium.edu.my/35192/
http://irep.iium.edu.my/35192/
http://irep.iium.edu.my/35192/1/Abdul_Mudalip_et_al_2013.pdf
first_indexed 2023-09-18T20:50:32Z
last_indexed 2023-09-18T20:50:32Z
_version_ 1777409963811930112

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