Appraisement of Ranitidine Hydrochloride Tablet (USP150mg) Preparations from Few Selected Companies in Bangladesh
The study was aimed to evaluate the pharmaceutical properties of few selected generic products of ranitidine hydrochloride tablets available in retail pharmacies of Bangladesh. We collected 10 nationally manufactured generic ranitidine HCl tablets from local Market who followed USP specifications...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
ANSI
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/35264/ http://irep.iium.edu.my/35264/ http://irep.iium.edu.my/35264/1/PJN_2688.pdf |
| Summary: | The study was aimed to evaluate the pharmaceutical properties of few selected generic products
of ranitidine hydrochloride tablets available in retail pharmacies of Bangladesh. We collected 10 nationally
manufactured generic ranitidine HCl tablets from local Market who followed USP specifications and
examined their physical parameters and potency to check their compliance with the USP. The intention was
to evaluate the quality of this pharmaceuticals after 20 years of implementing the National Drug Policy in
1982. All tested ranitidine tablet samples (Rt1-Rt10) were selectively collected from local retail pharmacies
in Savar, Dhaka-1344, Bangladesh. Before purchasing the samples, their physical appearance, name of
manufacturer, batch number, date of manufacturing, expiry date, manufacturing license number and
Maximum Retail Price (MRP) were properly checked. The various parameters of the selected samples such
as diameter, shape, size, weight variation, thickness, hardness, disintegration, dissolution and potency have
been determined according to the American Pharmacopoeia USP 27 requirements. It was found that all ten
selected products met the USP 27 specifications. The differences in hardness among the tablets were
significant. Interestingly, dissolution profiles of some tablet products were not weighty different from one
another, whereas those of tablets were significantly different. However, all brands complied with USP 27. It
could be concluded that the selected ranitidine HCl tablets met the required USP specifications and are
considered quality products in terms of the mentioned parameters. |
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