Evaluation of antimalaria activity and acute toxicity of Xetospongia sp

We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and esta...

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Main Authors:	Abdillah, Syamsudin, Noor, Noriah Mohd, Ahmad, Rahmatul Wahidah, Parama Cita, Yatnita
Format:	Article
Language:	English
Published:	Science Publications 2013
Subjects:	R Medicine (General) RA0421 Public health. Hygiene. Preventive Medicine RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/35947/ http://irep.iium.edu.my/35947/ http://irep.iium.edu.my/35947/1/journal_malaria_syamsul.pdf

id	iium-35947
recordtype	eprints
spelling	iium-359472014-05-06T06:53:17Z http://irep.iium.edu.my/35947/ Evaluation of antimalaria activity and acute toxicity of Xetospongia sp Abdillah, Syamsudin Noor, Noriah Mohd Ahmad, Rahmatul Wahidah Parama Cita, Yatnita R Medicine (General) RA0421 Public health. Hygiene. Preventive Medicine RM300 Drugs and their action We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute toxicity of extracts of Xetospongia sp at the dose 5000 mg kg-1 on mice administeredorally exhibited no toxicity, as evident in that fact that no histopathological changes were observed in some essential organs, such as liver, heart, digestive tract and kidney. The ethanolic extracts (50-400 mg kg day-1) exhibited a significant antimalarial activity both in the 4-day early infection test and in the established infection and they were found to be relatively safe up to a dosage of 5000 mg kg-1, with an LD50 value of >500 mg kg-1. Science Publications 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/35947/1/journal_malaria_syamsul.pdf Abdillah, Syamsudin and Noor, Noriah Mohd and Ahmad, Rahmatul Wahidah and Parama Cita, Yatnita (2013) Evaluation of antimalaria activity and acute toxicity of Xetospongia sp. American Journal of Pharmacology and Toxicology , 8 (2). pp. 83-88. ISSN 1557-4962 http://thescipub.com/ajpt.toc
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RA0421 Public health. Hygiene. Preventive Medicine RM300 Drugs and their action
spellingShingle	R Medicine (General) RA0421 Public health. Hygiene. Preventive Medicine RM300 Drugs and their action Abdillah, Syamsudin Noor, Noriah Mohd Ahmad, Rahmatul Wahidah Parama Cita, Yatnita Evaluation of antimalaria activity and acute toxicity of Xetospongia sp
description	We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute toxicity of extracts of Xetospongia sp at the dose 5000 mg kg-1 on mice administeredorally exhibited no toxicity, as evident in that fact that no histopathological changes were observed in some essential organs, such as liver, heart, digestive tract and kidney. The ethanolic extracts (50-400 mg kg day-1) exhibited a significant antimalarial activity both in the 4-day early infection test and in the established infection and they were found to be relatively safe up to a dosage of 5000 mg kg-1, with an LD50 value of >500 mg kg-1.
format	Article
author	Abdillah, Syamsudin Noor, Noriah Mohd Ahmad, Rahmatul Wahidah Parama Cita, Yatnita
author_facet	Abdillah, Syamsudin Noor, Noriah Mohd Ahmad, Rahmatul Wahidah Parama Cita, Yatnita
author_sort	Abdillah, Syamsudin
title	Evaluation of antimalaria activity and acute toxicity of Xetospongia sp
title_short	Evaluation of antimalaria activity and acute toxicity of Xetospongia sp
title_full	Evaluation of antimalaria activity and acute toxicity of Xetospongia sp
title_fullStr	Evaluation of antimalaria activity and acute toxicity of Xetospongia sp
title_full_unstemmed	Evaluation of antimalaria activity and acute toxicity of Xetospongia sp
title_sort	evaluation of antimalaria activity and acute toxicity of xetospongia sp
publisher	Science Publications
publishDate	2013
url	http://irep.iium.edu.my/35947/ http://irep.iium.edu.my/35947/ http://irep.iium.edu.my/35947/1/journal_malaria_syamsul.pdf
first_indexed	2023-09-18T20:51:29Z
last_indexed	2023-09-18T20:51:29Z
_version_	1777410023485341696

Evaluation of antimalaria activity and acute toxicity of Xetospongia sp

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