Biochemical and histological evaluation of Garcinia mangostana linn. on streptozotocin-induced diabetic rats

The aim of the present study was to evaluate the biochemical effects and histopathological alterations of the ethanolic extracts of Garcinia mangostana pericarps (GME) on STZ-induced diabetic rats. Oral administration of GME at doses of 50, 100 and 200 mg/kg b.w. were given to STZ-induced diabetic a...

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Main Authors:	Tg Zakaria, Tg Muhammad Faris Syafiq, Bakhtiar, M. Taher, Azad, Abul Kalam
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/36155/ http://irep.iium.edu.my/36155/ http://irep.iium.edu.my/36155/1/Binder1.pdf

id	iium-36155
recordtype	eprints
spelling	iium-361552014-04-16T00:44:39Z http://irep.iium.edu.my/36155/ Biochemical and histological evaluation of Garcinia mangostana linn. on streptozotocin-induced diabetic rats Tg Zakaria, Tg Muhammad Faris Syafiq Bakhtiar, M. Taher Azad, Abul Kalam RS Pharmacy and materia medica The aim of the present study was to evaluate the biochemical effects and histopathological alterations of the ethanolic extracts of Garcinia mangostana pericarps (GME) on STZ-induced diabetic rats. Oral administration of GME at doses of 50, 100 and 200 mg/kg b.w. were given to STZ-induced diabetic and normoglycaemic albino rats. The serum biochemical parameters, enzymatic analysis and histopathological alterations were examined and compared to reference standard hypoglycamic drug, glibenclamide. Analytes including blood glucose, liver transminases viz. alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALT), lipid profile included triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), Low density lipoprotein (LDL) and very low density lipoprotein (VLDL); creatinine, urea and total protein were checked using standard test kits and reagents. Histological changes in the liver, kidney and pancreas of the animals were also examined. The results obtained revealed a significant reduction of glucose level in GME with doses of 100 mg/kg (p<0.00l) and 200 mg/kg (p<0.00l) compared to 50 mg/kg. Total cholesterol, serum triglyceride, LDL, VLDL, urea and creatinine were reduced in the treatment group while total protein contents and HDL level mildly elevated. Histological assessment revealed a reduction in lesions associated with diabetic state in STZ-induced rats. The implications of the results obtained especially the reduction in glucose and improved biochemical function by G. mangostana suggested their potential to use GME in the management of diabetes when administered in dose-dependent manner. 2013-03 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/36155/1/Binder1.pdf Tg Zakaria, Tg Muhammad Faris Syafiq and Bakhtiar, M. Taher and Azad, Abul Kalam (2013) Biochemical and histological evaluation of Garcinia mangostana linn. on streptozotocin-induced diabetic rats. In: International Conference on Natural Products 2014, 18th-19th March 2014, Palm Garden Hotel, IOI Resorts, Putrajaya, Malaysia. http://www.ukm.my/icnp2014/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Tg Zakaria, Tg Muhammad Faris Syafiq Bakhtiar, M. Taher Azad, Abul Kalam Biochemical and histological evaluation of Garcinia mangostana linn. on streptozotocin-induced diabetic rats
description	The aim of the present study was to evaluate the biochemical effects and histopathological alterations of the ethanolic extracts of Garcinia mangostana pericarps (GME) on STZ-induced diabetic rats. Oral administration of GME at doses of 50, 100 and 200 mg/kg b.w. were given to STZ-induced diabetic and normoglycaemic albino rats. The serum biochemical parameters, enzymatic analysis and histopathological alterations were examined and compared to reference standard hypoglycamic drug, glibenclamide. Analytes including blood glucose, liver transminases viz. alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALT), lipid profile included triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), Low density lipoprotein (LDL) and very low density lipoprotein (VLDL); creatinine, urea and total protein were checked using standard test kits and reagents. Histological changes in the liver, kidney and pancreas of the animals were also examined. The results obtained revealed a significant reduction of glucose level in GME with doses of 100 mg/kg (p<0.00l) and 200 mg/kg (p<0.00l) compared to 50 mg/kg. Total cholesterol, serum triglyceride, LDL, VLDL, urea and creatinine were reduced in the treatment group while total protein contents and HDL level mildly elevated. Histological assessment revealed a reduction in lesions associated with diabetic state in STZ-induced rats. The implications of the results obtained especially the reduction in glucose and improved biochemical function by G. mangostana suggested their potential to use GME in the management of diabetes when administered in dose-dependent manner.
format	Conference or Workshop Item
author	Tg Zakaria, Tg Muhammad Faris Syafiq Bakhtiar, M. Taher Azad, Abul Kalam
author_facet	Tg Zakaria, Tg Muhammad Faris Syafiq Bakhtiar, M. Taher Azad, Abul Kalam
author_sort	Tg Zakaria, Tg Muhammad Faris Syafiq
title	Biochemical and histological evaluation of Garcinia mangostana linn. on streptozotocin-induced diabetic rats
title_short	Biochemical and histological evaluation of Garcinia mangostana linn. on streptozotocin-induced diabetic rats
title_full	Biochemical and histological evaluation of Garcinia mangostana linn. on streptozotocin-induced diabetic rats
title_fullStr	Biochemical and histological evaluation of Garcinia mangostana linn. on streptozotocin-induced diabetic rats
title_full_unstemmed	Biochemical and histological evaluation of Garcinia mangostana linn. on streptozotocin-induced diabetic rats
title_sort	biochemical and histological evaluation of garcinia mangostana linn. on streptozotocin-induced diabetic rats
publishDate	2013
url	http://irep.iium.edu.my/36155/ http://irep.iium.edu.my/36155/ http://irep.iium.edu.my/36155/1/Binder1.pdf
first_indexed	2023-09-18T20:51:46Z
last_indexed	2023-09-18T20:51:46Z
_version_	1777410041379291136

Biochemical and histological evaluation of Garcinia mangostana linn. on streptozotocin-induced diabetic rats

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