Serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare

Serum; a clear portion of blood obtained after removing cells, platelets and clotting factors is a universal supplement commonly used in media for mammalian cell culture system. Serum contains amino acids, proteins, growth factors, hormones, vitamins, inorganic substances, nutrients and metabolites;...

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Main Authors:	Hashim, Yumi Zuhanis Has-Yun, Mel, Maizirwan, Mohd. Salleh, Hamzah, Ahmad Nor, Yusilawati, Othman, Siti Hajar, Wan Abdul Razak, Wan Yusra Hannanah
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	BL Religion
Online Access:	http://irep.iium.edu.my/3655/ http://irep.iium.edu.my/3655/ http://irep.iium.edu.my/3655/1/Paper_Serum_Yumi.pdf

id	iium-3655
recordtype	eprints
spelling	iium-36552019-11-23T20:38:03Z http://irep.iium.edu.my/3655/ Serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare Hashim, Yumi Zuhanis Has-Yun Mel, Maizirwan Mohd. Salleh, Hamzah Ahmad Nor, Yusilawati Othman, Siti Hajar Wan Abdul Razak, Wan Yusra Hannanah BL Religion Serum; a clear portion of blood obtained after removing cells, platelets and clotting factors is a universal supplement commonly used in media for mammalian cell culture system. Serum contains amino acids, proteins, growth factors, hormones, vitamins, inorganic substances, nutrients and metabolites; which promote and sustain cell growth as well as provide buffering condition and protection to cells. Serum, from various animal sources such as bovine and porcine can be obtained commercially from manufacturers. Although serum has long been used successfully in mammalian cell culture system, recent trend is moving towards serum alternatives and serum-free media. This is due to many factors including the ethical and animal welfare issues in serum processing and production. Further, large scale production of bio-products using mammalian cell culture system prefers defined media which offers reproducibility and ease of downstream purification. Nevertheless, development of serum-free media is tedious and somewhat involve high cost with inherent problem of low growth rate as compared to serum supplemented media. This review is set to explore the many facets of serum and serum-free media in mammalian cell culture bioprocessing. 2011-05-17 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/3655/1/Paper_Serum_Yumi.pdf Hashim, Yumi Zuhanis Has-Yun and Mel, Maizirwan and Mohd. Salleh, Hamzah and Ahmad Nor, Yusilawati and Othman, Siti Hajar and Wan Abdul Razak, Wan Yusra Hannanah (2011) Serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare. In: 2nd International Conference on Professional Ethics and Education in Engineering 2011 (ICEPEE'11), 17th-19th May 2011, Kuala Lumpur. http://www.iium.edu.my/icepee/2011/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	BL Religion
spellingShingle	BL Religion Hashim, Yumi Zuhanis Has-Yun Mel, Maizirwan Mohd. Salleh, Hamzah Ahmad Nor, Yusilawati Othman, Siti Hajar Wan Abdul Razak, Wan Yusra Hannanah Serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare
description	Serum; a clear portion of blood obtained after removing cells, platelets and clotting factors is a universal supplement commonly used in media for mammalian cell culture system. Serum contains amino acids, proteins, growth factors, hormones, vitamins, inorganic substances, nutrients and metabolites; which promote and sustain cell growth as well as provide buffering condition and protection to cells. Serum, from various animal sources such as bovine and porcine can be obtained commercially from manufacturers. Although serum has long been used successfully in mammalian cell culture system, recent trend is moving towards serum alternatives and serum-free media. This is due to many factors including the ethical and animal welfare issues in serum processing and production. Further, large scale production of bio-products using mammalian cell culture system prefers defined media which offers reproducibility and ease of downstream purification. Nevertheless, development of serum-free media is tedious and somewhat involve high cost with inherent problem of low growth rate as compared to serum supplemented media. This review is set to explore the many facets of serum and serum-free media in mammalian cell culture bioprocessing.
format	Conference or Workshop Item
author	Hashim, Yumi Zuhanis Has-Yun Mel, Maizirwan Mohd. Salleh, Hamzah Ahmad Nor, Yusilawati Othman, Siti Hajar Wan Abdul Razak, Wan Yusra Hannanah
author_facet	Hashim, Yumi Zuhanis Has-Yun Mel, Maizirwan Mohd. Salleh, Hamzah Ahmad Nor, Yusilawati Othman, Siti Hajar Wan Abdul Razak, Wan Yusra Hannanah
author_sort	Hashim, Yumi Zuhanis Has-Yun
title	Serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare
title_short	Serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare
title_full	Serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare
title_fullStr	Serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare
title_full_unstemmed	Serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare
title_sort	serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare
publishDate	2011
url	http://irep.iium.edu.my/3655/ http://irep.iium.edu.my/3655/ http://irep.iium.edu.my/3655/1/Paper_Serum_Yumi.pdf
first_indexed	2023-09-18T20:11:33Z
last_indexed	2023-09-18T20:11:33Z
_version_	1777407511935057920

Serum in mammalian cell culture: weighing the challenges of bioprocessing, ethics and animal welfare

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