Screening of anticancer activity from agarwood essential oil

Background: Agarwood is a priceless non‑timber forest product from Aquilaria species belonging to the Thymelaeaceae family. As a result of a defence mechanism to fend off pathogens, Aquilaria species develop agarwood or resin which can be used for incense, perfumery, and traditional medicines. Ev...

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Main Authors:	Hashim, Yumi Zuhanis Has-Yun, Phirdaous, Abbas, Amid, Azura
Format:	Article
Language:	English
Published:	Wolters Kluwer 2014
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/36940/ http://irep.iium.edu.my/36940/ http://irep.iium.edu.my/36940/ http://irep.iium.edu.my/36940/1/yUMI_PHIRDAOUS-UPhcogRes_2014_6_3_191_132593.pdf

id	iium-36940
recordtype	eprints
spelling	iium-369402018-06-12T07:31:11Z http://irep.iium.edu.my/36940/ Screening of anticancer activity from agarwood essential oil Hashim, Yumi Zuhanis Has-Yun Phirdaous, Abbas Amid, Azura TP248.13 Biotechnology Background: Agarwood is a priceless non‑timber forest product from Aquilaria species belonging to the Thymelaeaceae family. As a result of a defence mechanism to fend off pathogens, Aquilaria species develop agarwood or resin which can be used for incense, perfumery, and traditional medicines. Evidences from ethnopharmacological practices showed that Aquilaria spp. have been traditionally used in the Ayurvedic practice and Chinese medicine to treat various diseases particularly the inflammatory‑associated diseases. There have been no reports on traditional use of agarwood towards cancer treatment. However, this is most probably due to the fact that cancer nomenclature is used in modern medicine to describe the diseases associated with unregulated cell growth in which inflammation and body pain are involved. Objective: The aim of this current study was therefore to investigate the potential anticancer properties of agarwood essential oil obtained from distillation of agarwood (resin) towards MCF‑7 breast cancer cells. Materials and Methods: The essential oil was subjected to screening assays namely cell viability, cell attachment and sulforhodamine B (SRB)‑based cytotoxicity assay to determine the IC50 value. Results: The agarwood essential oil caused reduction of the cell number in both the cell viability and attachment assay suggesting a cumulative effect of the cell killing, inhibition of the cell attachment and or causing cells to detach. The agarwood essential oil showed IC50 value of 900 μg/ml towards the cancer cells. Conclusion: The agarwood essential oil exhibited anticancer activity which supports the traditional use against the inflammatory‑associated diseases. This warrants further investigation towards the development of alternative remedy towards cancer. Wolters Kluwer 2014-05-16 Article PeerReviewed application/pdf en http://irep.iium.edu.my/36940/1/yUMI_PHIRDAOUS-UPhcogRes_2014_6_3_191_132593.pdf Hashim, Yumi Zuhanis Has-Yun and Phirdaous, Abbas and Amid, Azura (2014) Screening of anticancer activity from agarwood essential oil. Pharmacognosy Research, 6 (3). pp. 191-194. ISSN 0974-8490 http://www.phcogres.com/article.asp?issn=0974-8490;year=2014;volume=6;issue=3;spage=191;epage=194;aulast=Hashim;type=0 10.4103/0974-8490.132593
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Hashim, Yumi Zuhanis Has-Yun Phirdaous, Abbas Amid, Azura Screening of anticancer activity from agarwood essential oil
description	Background: Agarwood is a priceless non‑timber forest product from Aquilaria species belonging to the Thymelaeaceae family. As a result of a defence mechanism to fend off pathogens, Aquilaria species develop agarwood or resin which can be used for incense, perfumery, and traditional medicines. Evidences from ethnopharmacological practices showed that Aquilaria spp. have been traditionally used in the Ayurvedic practice and Chinese medicine to treat various diseases particularly the inflammatory‑associated diseases. There have been no reports on traditional use of agarwood towards cancer treatment. However, this is most probably due to the fact that cancer nomenclature is used in modern medicine to describe the diseases associated with unregulated cell growth in which inflammation and body pain are involved. Objective: The aim of this current study was therefore to investigate the potential anticancer properties of agarwood essential oil obtained from distillation of agarwood (resin) towards MCF‑7 breast cancer cells. Materials and Methods: The essential oil was subjected to screening assays namely cell viability, cell attachment and sulforhodamine B (SRB)‑based cytotoxicity assay to determine the IC50 value. Results: The agarwood essential oil caused reduction of the cell number in both the cell viability and attachment assay suggesting a cumulative effect of the cell killing, inhibition of the cell attachment and or causing cells to detach. The agarwood essential oil showed IC50 value of 900 μg/ml towards the cancer cells. Conclusion: The agarwood essential oil exhibited anticancer activity which supports the traditional use against the inflammatory‑associated diseases. This warrants further investigation towards the development of alternative remedy towards cancer.
format	Article
author	Hashim, Yumi Zuhanis Has-Yun Phirdaous, Abbas Amid, Azura
author_facet	Hashim, Yumi Zuhanis Has-Yun Phirdaous, Abbas Amid, Azura
author_sort	Hashim, Yumi Zuhanis Has-Yun
title	Screening of anticancer activity from agarwood essential oil
title_short	Screening of anticancer activity from agarwood essential oil
title_full	Screening of anticancer activity from agarwood essential oil
title_fullStr	Screening of anticancer activity from agarwood essential oil
title_full_unstemmed	Screening of anticancer activity from agarwood essential oil
title_sort	screening of anticancer activity from agarwood essential oil
publisher	Wolters Kluwer
publishDate	2014
url	http://irep.iium.edu.my/36940/ http://irep.iium.edu.my/36940/ http://irep.iium.edu.my/36940/ http://irep.iium.edu.my/36940/1/yUMI_PHIRDAOUS-UPhcogRes_2014_6_3_191_132593.pdf
first_indexed	2023-09-18T20:52:59Z
last_indexed	2023-09-18T20:52:59Z
_version_	1777410118310166528

Screening of anticancer activity from agarwood essential oil

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