Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats
Neurodegenerative conditions continue to affect a large number of people. Despite numerous studies carried out in the last few decades, no effective treatment has been found and current management of neurodegenerative conditions are not effective, marred by side-effects, costly and could only prov...
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| Format: | Conference or Workshop Item |
| Language: | English |
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2013
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| Online Access: | http://irep.iium.edu.my/37102/ http://irep.iium.edu.my/37102/1/p88_mohdshafri.pdf |
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iium-37102 |
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eprints |
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iium-371022019-01-15T02:56:33Z http://irep.iium.edu.my/37102/ Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats Mohd Shafri, Mohd Affendi Mohamed, Farahidah Md Jaffri, Juliana Ithnin, Hairuszah Kyu, Kim Min Mat Jais, Abdul Manan RZ Other systems of medicine Neurodegenerative conditions continue to affect a large number of people. Despite numerous studies carried out in the last few decades, no effective treatment has been found and current management of neurodegenerative conditions are not effective, marred by side-effects, costly and could only provide symptomatic alleviations. Haruan or Channa striatus, is rich in many important amino acids and fatty acids, which may act as suitable pharmacological modulators to neuron cells as they have potential to cross the blood-brain barrier, have anti-oxidative action and may trigger neurite growth receptor on neuron cell’s surface. In an in vivo experiment using Sprague Dawley rats, the effect of haruan traditional formulation (HTF) on rats’ nose-dipping and rearing behaviours in neuroprotective and neuroregenerative assays was studied using a hole board maze. Two neurodegenerative agents, ketamine and methamphetamine, were given intraperitoneally, 4 four times a day at 2 hour interval at different doses and rats were further classified into a short (1 day) or long exposure (5 days) groups (n=5 per group). It was found that HTF could provide some neuroprotective (p < 0.01 for the nose dip and p < 0.05 for rearing; one way ANOVA with Tukey’s post hoc analysis) and neuroregenerative (p < 0.001 for both nose dip and rearing; one way ANOVA with Tukey’s post hoc analysis) effects on rats’ behaviour for the long exposure to ketamine group and not in other groups. The results suggests that HTF is studied further for its potential neuro-modifying properties, and treatment of neurodegenerative condition must take into account type and nature of degeneration as well as functional and numerical changes of the brain. 2013-08-27 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/37102/1/p88_mohdshafri.pdf Mohd Shafri, Mohd Affendi and Mohamed, Farahidah and Md Jaffri, Juliana and Ithnin, Hairuszah and Kyu, Kim Min and Mat Jais, Abdul Manan (2013) Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats. In: 9th International Conference on Cognitive Science (ICCS 2013), 27th-30th Aug. 2013, Kuching, Sarawak. (Unpublished) |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RZ Other systems of medicine |
| spellingShingle |
RZ Other systems of medicine Mohd Shafri, Mohd Affendi Mohamed, Farahidah Md Jaffri, Juliana Ithnin, Hairuszah Kyu, Kim Min Mat Jais, Abdul Manan Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats |
| description |
Neurodegenerative conditions continue to affect a large number of people. Despite numerous studies
carried out in the last few decades, no effective treatment has been found and current management of
neurodegenerative conditions are not effective, marred by side-effects, costly and could only provide
symptomatic alleviations. Haruan or Channa striatus, is rich in many important amino acids and fatty
acids, which may act as suitable pharmacological modulators to neuron cells as they have potential to
cross the blood-brain barrier, have anti-oxidative action and may trigger neurite growth receptor on
neuron cell’s surface. In an in vivo experiment using Sprague Dawley rats, the effect of haruan traditional
formulation (HTF) on rats’ nose-dipping and rearing behaviours in neuroprotective and neuroregenerative
assays was studied using a hole board maze. Two neurodegenerative agents, ketamine and
methamphetamine, were given intraperitoneally, 4 four times a day at 2 hour interval at different doses
and rats were further classified into a short (1 day) or long exposure (5 days) groups (n=5 per group). It
was found that HTF could provide some neuroprotective (p < 0.01 for the nose dip and p < 0.05 for
rearing; one way ANOVA with Tukey’s post hoc analysis) and neuroregenerative (p < 0.001 for both
nose dip and rearing; one way ANOVA with Tukey’s post hoc analysis) effects on rats’ behaviour for the
long exposure to ketamine group and not in other groups. The results suggests that HTF is studied further
for its potential neuro-modifying properties, and treatment of neurodegenerative condition must take into
account type and nature of degeneration as well as functional and numerical changes of the brain. |
| format |
Conference or Workshop Item |
| author |
Mohd Shafri, Mohd Affendi Mohamed, Farahidah Md Jaffri, Juliana Ithnin, Hairuszah Kyu, Kim Min Mat Jais, Abdul Manan |
| author_facet |
Mohd Shafri, Mohd Affendi Mohamed, Farahidah Md Jaffri, Juliana Ithnin, Hairuszah Kyu, Kim Min Mat Jais, Abdul Manan |
| author_sort |
Mohd Shafri, Mohd Affendi |
| title |
Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats |
| title_short |
Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats |
| title_full |
Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats |
| title_fullStr |
Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats |
| title_full_unstemmed |
Assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced Sprague dawley rats |
| title_sort |
assessment of behavioural effects following treatment with haruan traditional formulation in brain-damage induced sprague dawley rats |
| publishDate |
2013 |
| url |
http://irep.iium.edu.my/37102/ http://irep.iium.edu.my/37102/1/p88_mohdshafri.pdf |
| first_indexed |
2023-09-18T20:53:12Z |
| last_indexed |
2023-09-18T20:53:12Z |
| _version_ |
1777410132047560704 |