Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity
Emerging clinical and preclinical evidence suggests that a compound displaying high affinity for μ, κ, and δ opioid (MOP, KOP, and DOP) receptors and antagonist activity at each, coupled with moderate affinity and efficacy at nociceptin opioid peptide (NOP) receptors will have utility as a relapse p...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/37816/ http://irep.iium.edu.my/37816/ http://irep.iium.edu.my/37816/ http://irep.iium.edu.my/37816/1/Irna_Elina_%28Journal_of_Medicinal_Chemistry%29.pdf |