Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis

Critically ill patients with sepsis can develop profound pathophysiological changes that may alter antibiotic pharmacokinetics (PK) and produce sub-therapeutic concentrations at the sites of infection leading to therapeutic failure. We aimed to describe the plasma PK of piperacillin and its associat...

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Main Authors:	Abdul Aziz, Mohd. Hafiz, Udy, Andrew A., Wallis, Steven C., Roberts, Michael S., Lipman, Jeffrey, Roberts, Jason A.
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/37925/ http://irep.iium.edu.my/37925/ http://irep.iium.edu.my/37925/2/912199_ECCMID2014_LR24.pdf http://irep.iium.edu.my/37925/7/ECCMID_PACE_Poster_Finalv2.pdf

id	iium-37925
recordtype	eprints
spelling	iium-379252018-06-25T01:00:16Z http://irep.iium.edu.my/37925/ Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis Abdul Aziz, Mohd. Hafiz Udy, Andrew A. Wallis, Steven C. Roberts, Michael S. Lipman, Jeffrey Roberts, Jason A. RM Therapeutics. Pharmacology RS Pharmacy and materia medica Critically ill patients with sepsis can develop profound pathophysiological changes that may alter antibiotic pharmacokinetics (PK) and produce sub-therapeutic concentrations at the sites of infection leading to therapeutic failure. We aimed to describe the plasma PK of piperacillin and its associated penetration into interstitial fluid (ISF) of subcutaneous tissue. We also sought to describe risk factors for not achieving PK/pharmacodynamic (PK/PD) targets in critically ill patients with sepsis. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/37925/2/912199_ECCMID2014_LR24.pdf application/pdf en http://irep.iium.edu.my/37925/7/ECCMID_PACE_Poster_Finalv2.pdf Abdul Aziz, Mohd. Hafiz and Udy, Andrew A. and Wallis, Steven C. and Roberts, Michael S. and Lipman, Jeffrey and Roberts, Jason A. (2014) Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis. In: 24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2014), 10th-13th May 2014, Barcelona, Spain. http://2014.eccmid.org/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Abdul Aziz, Mohd. Hafiz Udy, Andrew A. Wallis, Steven C. Roberts, Michael S. Lipman, Jeffrey Roberts, Jason A. Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis
description	Critically ill patients with sepsis can develop profound pathophysiological changes that may alter antibiotic pharmacokinetics (PK) and produce sub-therapeutic concentrations at the sites of infection leading to therapeutic failure. We aimed to describe the plasma PK of piperacillin and its associated penetration into interstitial fluid (ISF) of subcutaneous tissue. We also sought to describe risk factors for not achieving PK/pharmacodynamic (PK/PD) targets in critically ill patients with sepsis.
format	Conference or Workshop Item
author	Abdul Aziz, Mohd. Hafiz Udy, Andrew A. Wallis, Steven C. Roberts, Michael S. Lipman, Jeffrey Roberts, Jason A.
author_facet	Abdul Aziz, Mohd. Hafiz Udy, Andrew A. Wallis, Steven C. Roberts, Michael S. Lipman, Jeffrey Roberts, Jason A.
author_sort	Abdul Aziz, Mohd. Hafiz
title	Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis
title_short	Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis
title_full	Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis
title_fullStr	Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis
title_full_unstemmed	Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis
title_sort	plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis
publishDate	2014
url	http://irep.iium.edu.my/37925/ http://irep.iium.edu.my/37925/ http://irep.iium.edu.my/37925/2/912199_ECCMID2014_LR24.pdf http://irep.iium.edu.my/37925/7/ECCMID_PACE_Poster_Finalv2.pdf
first_indexed	2023-09-18T20:54:23Z
last_indexed	2023-09-18T20:54:23Z
_version_	1777410206367481856

Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis

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