The effects of Angiotensin-converting-enzyme inhibitor (Enalapril) on gentamicin nephrotoxicity

Gentamicin (GM) is one of Aminoglycosides widely used for the treatment of serious gram negative infections. Many risk factors associated with aminoglycosides nephrotoxicity have been identified in human and experimental animals. Enalapril is one of Angiotensin converting enzyme inhibitors (ACEI) wh...

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Main Authors:	Al-Ani, Imad Matloub Dally, Nafie, Emad M., Algantri, Khaled R.
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	RB Pathology RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/38061/ http://irep.iium.edu.my/38061/ http://irep.iium.edu.my/38061/2/Enalapril_presentation.pdf http://irep.iium.edu.my/38061/5/Binder1.pdf

id	iium-38061
recordtype	eprints
spelling	iium-380612015-12-18T02:36:22Z http://irep.iium.edu.my/38061/ The effects of Angiotensin-converting-enzyme inhibitor (Enalapril) on gentamicin nephrotoxicity Al-Ani, Imad Matloub Dally Nafie, Emad M. Algantri, Khaled R. RB Pathology RM300 Drugs and their action Gentamicin (GM) is one of Aminoglycosides widely used for the treatment of serious gram negative infections. Many risk factors associated with aminoglycosides nephrotoxicity have been identified in human and experimental animals. Enalapril is one of Angiotensin converting enzyme inhibitors (ACEI) which is widely used for the treatment of hypertension and heart failure. It has been suggested that (ACEI) may increase or decrease the nephrotoxicity of Aminoglycosides. The present study was undertaken to evaluate the concomitant administration of Enalapril and Gentamicin. Sixty healthy adult male Sprague Dawley rats were divided into four major groups of 15 rats each (according to the dosage of administered drug). Each major group was further subdivided into three minor groups according to the sacrificing day. Group (C) = control group were administered daily with normal saline, group (G) were given 75 mg/kg GM, group (E) were given oral enalapril and group (G + E) were GM and enalapril. Treatment continued daily for 15 days and experimental analysis has been done on day 5, 10 and 15. It has been found that GN nephrotoxicity increased with the duration of treatment through elevation of serum creatinine and blood urea nitrogen at the 10th day and continued to increase significantly throughout the experiment at the 15th day. Animals treated with Enalapril showed no significant alteration from those of controls, while the concomitant administration of Enalapril and GM revealed that Enalapril progressively aggravated GN nephrotoxicity, these physiological alterations were associated with severe renal histopathological changes induced by GM. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/38061/2/Enalapril_presentation.pdf application/pdf en http://irep.iium.edu.my/38061/5/Binder1.pdf Al-Ani, Imad Matloub Dally and Nafie, Emad M. and Algantri, Khaled R. (2014) The effects of Angiotensin-converting-enzyme inhibitor (Enalapril) on gentamicin nephrotoxicity. In: Pharmacology & Physiology International Scientific Congress (2014), 22-24 August 2014, Kuala Lumpur. (Unpublished) http://www.msppscientificmeetings.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RB Pathology RM300 Drugs and their action
spellingShingle	RB Pathology RM300 Drugs and their action Al-Ani, Imad Matloub Dally Nafie, Emad M. Algantri, Khaled R. The effects of Angiotensin-converting-enzyme inhibitor (Enalapril) on gentamicin nephrotoxicity
description	Gentamicin (GM) is one of Aminoglycosides widely used for the treatment of serious gram negative infections. Many risk factors associated with aminoglycosides nephrotoxicity have been identified in human and experimental animals. Enalapril is one of Angiotensin converting enzyme inhibitors (ACEI) which is widely used for the treatment of hypertension and heart failure. It has been suggested that (ACEI) may increase or decrease the nephrotoxicity of Aminoglycosides. The present study was undertaken to evaluate the concomitant administration of Enalapril and Gentamicin. Sixty healthy adult male Sprague Dawley rats were divided into four major groups of 15 rats each (according to the dosage of administered drug). Each major group was further subdivided into three minor groups according to the sacrificing day. Group (C) = control group were administered daily with normal saline, group (G) were given 75 mg/kg GM, group (E) were given oral enalapril and group (G + E) were GM and enalapril. Treatment continued daily for 15 days and experimental analysis has been done on day 5, 10 and 15. It has been found that GN nephrotoxicity increased with the duration of treatment through elevation of serum creatinine and blood urea nitrogen at the 10th day and continued to increase significantly throughout the experiment at the 15th day. Animals treated with Enalapril showed no significant alteration from those of controls, while the concomitant administration of Enalapril and GM revealed that Enalapril progressively aggravated GN nephrotoxicity, these physiological alterations were associated with severe renal histopathological changes induced by GM.
format	Conference or Workshop Item
author	Al-Ani, Imad Matloub Dally Nafie, Emad M. Algantri, Khaled R.
author_facet	Al-Ani, Imad Matloub Dally Nafie, Emad M. Algantri, Khaled R.
author_sort	Al-Ani, Imad Matloub Dally
title	The effects of Angiotensin-converting-enzyme inhibitor (Enalapril) on gentamicin nephrotoxicity
title_short	The effects of Angiotensin-converting-enzyme inhibitor (Enalapril) on gentamicin nephrotoxicity
title_full	The effects of Angiotensin-converting-enzyme inhibitor (Enalapril) on gentamicin nephrotoxicity
title_fullStr	The effects of Angiotensin-converting-enzyme inhibitor (Enalapril) on gentamicin nephrotoxicity
title_full_unstemmed	The effects of Angiotensin-converting-enzyme inhibitor (Enalapril) on gentamicin nephrotoxicity
title_sort	effects of angiotensin-converting-enzyme inhibitor (enalapril) on gentamicin nephrotoxicity
publishDate	2014
url	http://irep.iium.edu.my/38061/ http://irep.iium.edu.my/38061/ http://irep.iium.edu.my/38061/2/Enalapril_presentation.pdf http://irep.iium.edu.my/38061/5/Binder1.pdf
first_indexed	2023-09-18T20:54:37Z
last_indexed	2023-09-18T20:54:37Z
_version_	1777410221239435264

The effects of Angiotensin-converting-enzyme inhibitor (Enalapril) on gentamicin nephrotoxicity

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