Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application

Raloxifene hydrochloride, a highly effective drug for the treatment of invasive breast cancer and osteoporosis in post-menopausal women, shows poor oral bioavailability of 2%. The aim of this study was to develop, statistically optimize, and characterize raloxifene hydrochloride-loaded transferso...

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Main Authors:	Mahmood, Syed, Bakhtiar, M. Taher, Mandal, Uttam Kumar
Format:	Article
Language:	English English English
Published:	DOVE Medical Press, Auckland 2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/38263/ http://irep.iium.edu.my/38263/ http://irep.iium.edu.my/38263/ http://irep.iium.edu.my/38263/1/IJN-65408-design-and-rsm-optimization-of-raloxifene-hcl-loaded-nanotra_091214.pdf http://irep.iium.edu.my/38263/4/WOS_Q1.pdf http://irep.iium.edu.my/38263/6/38263_Experimental%20design%20and%20optimization_Scopus.pdf

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recordtype	eprints
spelling	iium-382632017-08-25T08:01:21Z http://irep.iium.edu.my/38263/ Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application Mahmood, Syed Bakhtiar, M. Taher Mandal, Uttam Kumar RS Pharmacy and materia medica Raloxifene hydrochloride, a highly effective drug for the treatment of invasive breast cancer and osteoporosis in post-menopausal women, shows poor oral bioavailability of 2%. The aim of this study was to develop, statistically optimize, and characterize raloxifene hydrochloride-loaded transfersomes for transdermal delivery, in order to overcome the poor bioavailability issue with the drug. A response surface methodology experimental design was applied for the optimization of transfersomes, using Box-Behnken experimental design. Phospholipon ® 90G, sodium deoxycholate, and sonication time, each at three levels, were selected as independent variables, while entrapment efficiency, vesicle size, and transdermal flux were identified as dependent variables. The formulation was characterized by surface morphology and shape, particle size, and zeta potential. Ex vivo transdermal flux was determined using a Hanson diffusion cell assembly, with rat skin as a barrier medium. Transfersomes from the optimized formulation were found to have spherical, unilamellar structures, with a homogeneous distribution and low polydispersity index (0.08). They had a particle size of 134 DOVE Medical Press, Auckland 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/38263/1/IJN-65408-design-and-rsm-optimization-of-raloxifene-hcl-loaded-nanotra_091214.pdf application/pdf en http://irep.iium.edu.my/38263/4/WOS_Q1.pdf application/pdf en http://irep.iium.edu.my/38263/6/38263_Experimental%20design%20and%20optimization_Scopus.pdf Mahmood, Syed and Bakhtiar, M. Taher and Mandal, Uttam Kumar (2014) Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application. International Journal of Nanomedicine, 2014 (9). pp. 4331-4346. ISSN 1178-2013 http://dx.doi.org/10.2147/IJN.S65408 10.2147/IJN.S65408
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mahmood, Syed Bakhtiar, M. Taher Mandal, Uttam Kumar Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application
description	Raloxifene hydrochloride, a highly effective drug for the treatment of invasive breast cancer and osteoporosis in post-menopausal women, shows poor oral bioavailability of 2%. The aim of this study was to develop, statistically optimize, and characterize raloxifene hydrochloride-loaded transfersomes for transdermal delivery, in order to overcome the poor bioavailability issue with the drug. A response surface methodology experimental design was applied for the optimization of transfersomes, using Box-Behnken experimental design. Phospholipon ® 90G, sodium deoxycholate, and sonication time, each at three levels, were selected as independent variables, while entrapment efficiency, vesicle size, and transdermal flux were identified as dependent variables. The formulation was characterized by surface morphology and shape, particle size, and zeta potential. Ex vivo transdermal flux was determined using a Hanson diffusion cell assembly, with rat skin as a barrier medium. Transfersomes from the optimized formulation were found to have spherical, unilamellar structures, with a homogeneous distribution and low polydispersity index (0.08). They had a particle size of 134
format	Article
author	Mahmood, Syed Bakhtiar, M. Taher Mandal, Uttam Kumar
author_facet	Mahmood, Syed Bakhtiar, M. Taher Mandal, Uttam Kumar
author_sort	Mahmood, Syed
title	Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application
title_short	Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application
title_full	Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application
title_fullStr	Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application
title_full_unstemmed	Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application
title_sort	experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application
publisher	DOVE Medical Press, Auckland
publishDate	2014
url	http://irep.iium.edu.my/38263/ http://irep.iium.edu.my/38263/ http://irep.iium.edu.my/38263/ http://irep.iium.edu.my/38263/1/IJN-65408-design-and-rsm-optimization-of-raloxifene-hcl-loaded-nanotra_091214.pdf http://irep.iium.edu.my/38263/4/WOS_Q1.pdf http://irep.iium.edu.my/38263/6/38263_Experimental%20design%20and%20optimization_Scopus.pdf
first_indexed	2023-09-18T20:54:57Z
last_indexed	2023-09-18T20:54:57Z
_version_	1777410242279112704

Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application

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