Effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment

In recent years, the use of Eurycoma longifolia Jack (ELJ) (Tongkat Ali) has spread dramatically in Southeast Asia especially Malaysia where it is widely used as aphrodisiac and anti-malarial agents. Interestingly, its consumption has become popular in daily life as beverage to enhance energy and st...

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Main Authors:	Alfaqeh, Hamoud Hussein Mohammed, Ahmed, Qamar Uddin
Format:	Article
Language:	English
Published:	Tissue Engineering and Regenerative Medicine Society of Malaysia 2013
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/38292/ http://irep.iium.edu.my/38292/ http://irep.iium.edu.my/38292/1/ELJ_and_Pancreas_was_published_2013.pdf

id	iium-38292
recordtype	eprints
spelling	iium-382922015-05-26T07:58:45Z http://irep.iium.edu.my/38292/ Effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment Alfaqeh, Hamoud Hussein Mohammed Ahmed, Qamar Uddin RB Pathology In recent years, the use of Eurycoma longifolia Jack (ELJ) (Tongkat Ali) has spread dramatically in Southeast Asia especially Malaysia where it is widely used as aphrodisiac and anti-malarial agents. Interestingly, its consumption has become popular in daily life as beverage to enhance energy and stamina especially among males. However, its effect on the safety of vital organs of the body is not studied properly. Hence, the main objective of this study was to determine whether or not long-term use of ELJ has side effects on pancreas in rats. Three different concentrations of aqueous extract of ELJ were prepared and dissolved in distilled water, a total of thirty two Sprague-Dawley male rats were used and randomly divided into three test groups and control. The three test groups were given different doses (low dose 250 mg/kg bw, medium dose 500 mg /kg bw and high dose 1000 mg/kg bw) of aqueous extract of ELJ, respectively. Control group was given distilled water alone. Doses were given orally, daily for about 5 weeks. After 5 weeks, animals were sacrificed; whole pancreas tissues were obtained, fixed in 10 percent formaldehyde solution overnight for histological examination. Histological observations showed no signs of hemorrhage, fatty changes and normal pancreatic tissues in the three test groups when compared to normal. As a conclusion, the daily consumption of ELJ as beverage has no side effect on pancreatic tissue when taken in small quantity for long duration. Tissue Engineering and Regenerative Medicine Society of Malaysia 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/38292/1/ELJ_and_Pancreas_was_published_2013.pdf Alfaqeh, Hamoud Hussein Mohammed and Ahmed, Qamar Uddin (2013) Effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment. Regenerative Research, 2 (2). pp. 22-25. ISSN 2232-0822 (O) http://regres.tesma.org.my/vol2-2.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Alfaqeh, Hamoud Hussein Mohammed Ahmed, Qamar Uddin Effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment
description	In recent years, the use of Eurycoma longifolia Jack (ELJ) (Tongkat Ali) has spread dramatically in Southeast Asia especially Malaysia where it is widely used as aphrodisiac and anti-malarial agents. Interestingly, its consumption has become popular in daily life as beverage to enhance energy and stamina especially among males. However, its effect on the safety of vital organs of the body is not studied properly. Hence, the main objective of this study was to determine whether or not long-term use of ELJ has side effects on pancreas in rats. Three different concentrations of aqueous extract of ELJ were prepared and dissolved in distilled water, a total of thirty two Sprague-Dawley male rats were used and randomly divided into three test groups and control. The three test groups were given different doses (low dose 250 mg/kg bw, medium dose 500 mg /kg bw and high dose 1000 mg/kg bw) of aqueous extract of ELJ, respectively. Control group was given distilled water alone. Doses were given orally, daily for about 5 weeks. After 5 weeks, animals were sacrificed; whole pancreas tissues were obtained, fixed in 10 percent formaldehyde solution overnight for histological examination. Histological observations showed no signs of hemorrhage, fatty changes and normal pancreatic tissues in the three test groups when compared to normal. As a conclusion, the daily consumption of ELJ as beverage has no side effect on pancreatic tissue when taken in small quantity for long duration.
format	Article
author	Alfaqeh, Hamoud Hussein Mohammed Ahmed, Qamar Uddin
author_facet	Alfaqeh, Hamoud Hussein Mohammed Ahmed, Qamar Uddin
author_sort	Alfaqeh, Hamoud Hussein Mohammed
title	Effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment
title_short	Effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment
title_full	Effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment
title_fullStr	Effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment
title_full_unstemmed	Effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment
title_sort	effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment
publisher	Tissue Engineering and Regenerative Medicine Society of Malaysia
publishDate	2013
url	http://irep.iium.edu.my/38292/ http://irep.iium.edu.my/38292/ http://irep.iium.edu.my/38292/1/ELJ_and_Pancreas_was_published_2013.pdf
first_indexed	2023-09-18T20:55:00Z
last_indexed	2023-09-18T20:55:00Z
_version_	1777410245062033408

Effect of long-term use of eurycoma longifolia jack on the pancreas in rats: histological assessment

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