Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain

The contributing molecular pathways underlying the pathogenesis of breast cancer need to be better characterized. The goal of the present study is to understand the probable molecular mechanism and the associated pathway related to recombinant bromelain treatment on MCF-7 breast cancer cells. Wit...

Full description

Bibliographic Details
Main Authors:	Fouz, Nour, Amid, Azura, Hashim, Yumi Zuhanis Has-Yun
Format:	Article
Language:	English English
Published:	Journal of Pure and Applied Microbiology 2014
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/38444/ http://irep.iium.edu.my/38444/ http://irep.iium.edu.my/38444/1/May_Nour_JPAM.pdf http://irep.iium.edu.my/38444/3/38444_Pathway%20analysis%20of%20genes%20affected%20in.SCOPUS.pdf

id	iium-38444
recordtype	eprints
spelling	iium-384442018-06-12T03:41:10Z http://irep.iium.edu.my/38444/ Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain Fouz, Nour Amid, Azura Hashim, Yumi Zuhanis Has-Yun TP248.13 Biotechnology The contributing molecular pathways underlying the pathogenesis of breast cancer need to be better characterized. The goal of the present study is to understand the probable molecular mechanism and the associated pathway related to recombinant bromelain treatment on MCF-7 breast cancer cells. Within 1102 known genes differentially expressed to a significant degree (p<0.001) set, 34 genes were significantly changed between treated cells and the control cells with cutoff fold change more than 2. These genes are LYRM2, TUBB2C, LRRFIP1, HMGN2, HMGN2, GLTSCR2, RN28S1, HIST2H4B, HIST2H4A, PA2G4, ACTB, C1orf152, RPS3A, C12orf51, RAP1B, FLJ16171, CCDC59, MGEA5, KIFAP3, GPBP1, KLHDC2, TBPL1, STK38L, RIOK3, CLK4 SNORD46, C7orf60, BTG1, TMEM59, ARID4A, C6orf62, FRG1, DEFB109P1B and RBMS1. With this exploratory study using Ingenuity Pathway Analysis IPA, we aim to identify the overlapping pathways associated with recombinant bromelain treatment and its anti-cancer mechanisms in MCF-7 breast cancer cells. The pathways identification has been shown to be associated with recombinant bromelain function on cell cycle, cancer, cell death & survival, cellular development, tumor morphology, cellular growth and proliferation. This finding will enhance the power of In-vitro breast cancer study and lead to better understanding Journal of Pure and Applied Microbiology 2014-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/38444/1/May_Nour_JPAM.pdf application/pdf en http://irep.iium.edu.my/38444/3/38444_Pathway%20analysis%20of%20genes%20affected%20in.SCOPUS.pdf Fouz, Nour and Amid, Azura and Hashim, Yumi Zuhanis Has-Yun (2014) Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain. Journal of Pure and Applied Microbiology, 8 (s.ed 1). pp. 681-689. ISSN 0973-7510 http://www.microbiologyjournal.org/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Fouz, Nour Amid, Azura Hashim, Yumi Zuhanis Has-Yun Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain
description	The contributing molecular pathways underlying the pathogenesis of breast cancer need to be better characterized. The goal of the present study is to understand the probable molecular mechanism and the associated pathway related to recombinant bromelain treatment on MCF-7 breast cancer cells. Within 1102 known genes differentially expressed to a significant degree (p<0.001) set, 34 genes were significantly changed between treated cells and the control cells with cutoff fold change more than 2. These genes are LYRM2, TUBB2C, LRRFIP1, HMGN2, HMGN2, GLTSCR2, RN28S1, HIST2H4B, HIST2H4A, PA2G4, ACTB, C1orf152, RPS3A, C12orf51, RAP1B, FLJ16171, CCDC59, MGEA5, KIFAP3, GPBP1, KLHDC2, TBPL1, STK38L, RIOK3, CLK4 SNORD46, C7orf60, BTG1, TMEM59, ARID4A, C6orf62, FRG1, DEFB109P1B and RBMS1. With this exploratory study using Ingenuity Pathway Analysis IPA, we aim to identify the overlapping pathways associated with recombinant bromelain treatment and its anti-cancer mechanisms in MCF-7 breast cancer cells. The pathways identification has been shown to be associated with recombinant bromelain function on cell cycle, cancer, cell death & survival, cellular development, tumor morphology, cellular growth and proliferation. This finding will enhance the power of In-vitro breast cancer study and lead to better understanding
format	Article
author	Fouz, Nour Amid, Azura Hashim, Yumi Zuhanis Has-Yun
author_facet	Fouz, Nour Amid, Azura Hashim, Yumi Zuhanis Has-Yun
author_sort	Fouz, Nour
title	Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain
title_short	Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain
title_full	Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain
title_fullStr	Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain
title_full_unstemmed	Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain
title_sort	pathway analysis of genes affected in mcf-7 breast cancer cells treated with recombinant bromelain
publisher	Journal of Pure and Applied Microbiology
publishDate	2014
url	http://irep.iium.edu.my/38444/ http://irep.iium.edu.my/38444/ http://irep.iium.edu.my/38444/1/May_Nour_JPAM.pdf http://irep.iium.edu.my/38444/3/38444_Pathway%20analysis%20of%20genes%20affected%20in.SCOPUS.pdf
first_indexed	2023-09-18T20:55:14Z
last_indexed	2023-09-18T20:55:14Z
_version_	1777410260045135872

Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain

Similar Items