Chronic LD50 vs safest dose for the methanolic extract of curry leaves (Murraya koenigii) cultivated in Malaysia

Chronic LD50 vs safest dose for the methanolic extract of curry leaves (Murraya koenigii) cultivated in Malaysia

Curry leaf viz. Murraya koenigiil eaves (MKL) is an ancient Ayurvedic medicinal plant that has recently been described as possessing robust anti-inflammatory and antioxidant activities. The current study was conducted to determine the long-term LD50 of the methanolic extract of MKL during daily or...

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Main Authors: Azzubaidi, Marwan Saad, Saxena, Anil Kumar, Alattraqchi, Ahmed Ghazi, Abdualkader, Abualrahman
Format: Article
Language:English
Published: Journal of Applied Pharmaceutical Science (http://www.japsonline.com) 2014
Subjects:
RA1190 Toxicology
RM Therapeutics. Pharmacology
Online Access:http://irep.iium.edu.my/38532/
http://irep.iium.edu.my/38532/
http://irep.iium.edu.my/38532/
http://irep.iium.edu.my/38532/1/Article_JAPS_2014.pdf
id iium-38532
recordtype eprints
spelling iium-385322018-06-19T03:56:07Z http://irep.iium.edu.my/38532/ Chronic LD50 vs safest dose for the methanolic extract of curry leaves (Murraya koenigii) cultivated in Malaysia Azzubaidi, Marwan Saad Saxena, Anil Kumar Alattraqchi, Ahmed Ghazi Abdualkader, Abualrahman RA1190 Toxicology RM Therapeutics. Pharmacology Curry leaf viz. Murraya koenigiil eaves (MKL) is an ancient Ayurvedic medicinal plant that has recently been described as possessing robust anti-inflammatory and antioxidant activities. The current study was conducted to determine the long-term LD50 of the methanolic extract of MKL during daily oral administration. Five groups of Sprague Dawley rats were recruited into the study. Each group comprised of six rats including the control group (1). The oral MKL doses used for groups (2) to (5) were 50, 100, 200 and 400 mg/kg/day, respectively for a duration of ten weeks. The daily measured toxicity parameters were food and water consumption, body weight, general activity in forced swimming test and the cumulative mortalities. Group (5) showed 100% mortality within the first month of the study. Group (4) showed 50% mortality with signs of toxicity for the other 3 animals. Group (3) showed no mortalities but signs of toxicity for one animal were observed. No mortalities or toxicity signs were observed for any of group (2) animals. It can be concluded that the chronic LD50 for Malaysian cultivated MKL is 200 mg/kg/day, and the safest dose of MKL methanolic extract that can be implemented for long-term studies should not exceed 50 mg/kg/day. Journal of Applied Pharmaceutical Science (http://www.japsonline.com) 2014-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/38532/1/Article_JAPS_2014.pdf Azzubaidi, Marwan Saad and Saxena, Anil Kumar and Alattraqchi, Ahmed Ghazi and Abdualkader, Abualrahman (2014) Chronic LD50 vs safest dose for the methanolic extract of curry leaves (Murraya koenigii) cultivated in Malaysia. Journal of Applied Pharmaceutical Science, 4 (8). pp. 56-58. ISSN 2231-3354 http://www.japsonline.com/abstract.php?article_id=1311 10.7324/JAPS.2014.40811
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RA1190 Toxicology
RM Therapeutics. Pharmacology
spellingShingle RA1190 Toxicology
RM Therapeutics. Pharmacology
Azzubaidi, Marwan Saad
Saxena, Anil Kumar
Alattraqchi, Ahmed Ghazi
Abdualkader, Abualrahman
Chronic LD50 vs safest dose for the methanolic extract of curry leaves (Murraya koenigii) cultivated in Malaysia
description Curry leaf viz. Murraya koenigiil eaves (MKL) is an ancient Ayurvedic medicinal plant that has recently been described as possessing robust anti-inflammatory and antioxidant activities. The current study was conducted to determine the long-term LD50 of the methanolic extract of MKL during daily oral administration. Five groups of Sprague Dawley rats were recruited into the study. Each group comprised of six rats including the control group (1). The oral MKL doses used for groups (2) to (5) were 50, 100, 200 and 400 mg/kg/day, respectively for a duration of ten weeks. The daily measured toxicity parameters were food and water consumption, body weight, general activity in forced swimming test and the cumulative mortalities. Group (5) showed 100% mortality within the first month of the study. Group (4) showed 50% mortality with signs of toxicity for the other 3 animals. Group (3) showed no mortalities but signs of toxicity for one animal were observed. No mortalities or toxicity signs were observed for any of group (2) animals. It can be concluded that the chronic LD50 for Malaysian cultivated MKL is 200 mg/kg/day, and the safest dose of MKL methanolic extract that can be implemented for long-term studies should not exceed 50 mg/kg/day.
format Article
author Azzubaidi, Marwan Saad
Saxena, Anil Kumar
Alattraqchi, Ahmed Ghazi
Abdualkader, Abualrahman
author_facet Azzubaidi, Marwan Saad
Saxena, Anil Kumar
Alattraqchi, Ahmed Ghazi
Abdualkader, Abualrahman
author_sort Azzubaidi, Marwan Saad
title Chronic LD50 vs safest dose for the methanolic extract of curry leaves (Murraya koenigii) cultivated in Malaysia
title_short Chronic LD50 vs safest dose for the methanolic extract of curry leaves (Murraya koenigii) cultivated in Malaysia
title_full Chronic LD50 vs safest dose for the methanolic extract of curry leaves (Murraya koenigii) cultivated in Malaysia
title_fullStr Chronic LD50 vs safest dose for the methanolic extract of curry leaves (Murraya koenigii) cultivated in Malaysia
title_full_unstemmed Chronic LD50 vs safest dose for the methanolic extract of curry leaves (Murraya koenigii) cultivated in Malaysia
title_sort chronic ld50 vs safest dose for the methanolic extract of curry leaves (murraya koenigii) cultivated in malaysia
publisher Journal of Applied Pharmaceutical Science (http://www.japsonline.com)
publishDate 2014
url http://irep.iium.edu.my/38532/
http://irep.iium.edu.my/38532/
http://irep.iium.edu.my/38532/
http://irep.iium.edu.my/38532/1/Article_JAPS_2014.pdf
first_indexed 2023-09-18T20:55:22Z
last_indexed 2023-09-18T20:55:22Z
_version_ 1777410267941961728

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