Dietary Zinc and the brain.

Zinc (Zn), after iron, is the second most abundant essential element in different organs of the human body. The amount of Zn to be absorbed and hence utilized or metabolized in different tissues depends on the total Zn content of the diet and its bioavailability, specially its solubility in the inte...

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Main Author:	Rahman, Mohammad Tariqur
Other Authors:	Preedy, Victor R
Format:	Book Chapter
Language:	English English
Published:	Springer Science Business Media 2011
Subjects:	QH301 Biology QP Physiology
Online Access:	http://irep.iium.edu.my/3883/ http://irep.iium.edu.my/3883/1/Dietary_Zn_and_Brain.pdf http://irep.iium.edu.my/3883/4/Book.pdf

id	iium-3883
recordtype	eprints
spelling	iium-38832012-02-28T05:56:21Z http://irep.iium.edu.my/3883/ Dietary Zinc and the brain. Rahman, Mohammad Tariqur QH301 Biology QP Physiology Zinc (Zn), after iron, is the second most abundant essential element in different organs of the human body. The amount of Zn to be absorbed and hence utilized or metabolized in different tissues depends on the total Zn content of the diet and its bioavailability, specially its solubility in the intestinal lumen. In the brain, additional control on the absorption, distribution, and homeostasis of Zn is maintained by the blood brain barrier system which generally is not easily disrupted by dietary Zn. In the brain, [Zn] is highest in the hippocampus but this can be decreased significantly in dietary Zn deficiency. Zinc homeostasis in the brain is maintained through the regulated expression of proteins for Zn import, export, and storage. Among them, Zn2+ transporters, Zn2+ importing proteins, and Zn2+ buffering proteins, such as the metallothioneins, bind cytosolic free Zn2+ and mediate the complex intraneuronal cytosolic Zn2+ homeostasis. In addition to its important roles as catalytic, co-catalytic, and structural component of many proteins, Zn is also important as an intracellular signaling factor in the regulation of cell proliferation. As an extracellular signaling factor, Zn is involved in synaptic neurotransmission. In neuronal cells, Zn deficiency induces oxidative stress, which consequently can induce decreased cell proliferation and increased apoptosis through activation and inactivation of several Zn finger transcription factors. Acute human dietary deficiency of Zn is associated with symptoms such as anorexia, smell and taste dysfunction, emotional and cognitive disturbances, and loss of coordination and other brain functions, including learning and memory defects. The intracellular Zn2+ availability is associated with decline in brain functions and impaired cognitive performances in old age. This chapter will elaborate on the physiological importance of dietary Zn in the brain with special reference to the mechanism of Zn homeostasis, the role of dietary Zn in brain development, and the consequences of an Zn excess and/or Zn deficient condition in brain pathology. Springer Science Business Media Preedy, Victor R 2011 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/3883/1/Dietary_Zn_and_Brain.pdf application/pdf en http://irep.iium.edu.my/3883/4/Book.pdf Rahman, Mohammad Tariqur (2011) Dietary Zinc and the brain. In: Handbook of behavior food and nutrition. Springer Science Business Media, New York , pp. 2357-2373. ISBN 9780387922706
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QH301 Biology QP Physiology
spellingShingle	QH301 Biology QP Physiology Rahman, Mohammad Tariqur Dietary Zinc and the brain.
description	Zinc (Zn), after iron, is the second most abundant essential element in different organs of the human body. The amount of Zn to be absorbed and hence utilized or metabolized in different tissues depends on the total Zn content of the diet and its bioavailability, specially its solubility in the intestinal lumen. In the brain, additional control on the absorption, distribution, and homeostasis of Zn is maintained by the blood brain barrier system which generally is not easily disrupted by dietary Zn. In the brain, [Zn] is highest in the hippocampus but this can be decreased significantly in dietary Zn deficiency. Zinc homeostasis in the brain is maintained through the regulated expression of proteins for Zn import, export, and storage. Among them, Zn2+ transporters, Zn2+ importing proteins, and Zn2+ buffering proteins, such as the metallothioneins, bind cytosolic free Zn2+ and mediate the complex intraneuronal cytosolic Zn2+ homeostasis. In addition to its important roles as catalytic, co-catalytic, and structural component of many proteins, Zn is also important as an intracellular signaling factor in the regulation of cell proliferation. As an extracellular signaling factor, Zn is involved in synaptic neurotransmission. In neuronal cells, Zn deficiency induces oxidative stress, which consequently can induce decreased cell proliferation and increased apoptosis through activation and inactivation of several Zn finger transcription factors. Acute human dietary deficiency of Zn is associated with symptoms such as anorexia, smell and taste dysfunction, emotional and cognitive disturbances, and loss of coordination and other brain functions, including learning and memory defects. The intracellular Zn2+ availability is associated with decline in brain functions and impaired cognitive performances in old age. This chapter will elaborate on the physiological importance of dietary Zn in the brain with special reference to the mechanism of Zn homeostasis, the role of dietary Zn in brain development, and the consequences of an Zn excess and/or Zn deficient condition in brain pathology.
author2	Preedy, Victor R
author_facet	Preedy, Victor R Rahman, Mohammad Tariqur
format	Book Chapter
author	Rahman, Mohammad Tariqur
author_sort	Rahman, Mohammad Tariqur
title	Dietary Zinc and the brain.
title_short	Dietary Zinc and the brain.
title_full	Dietary Zinc and the brain.
title_fullStr	Dietary Zinc and the brain.
title_full_unstemmed	Dietary Zinc and the brain.
title_sort	dietary zinc and the brain.
publisher	Springer Science Business Media
publishDate	2011
url	http://irep.iium.edu.my/3883/ http://irep.iium.edu.my/3883/1/Dietary_Zn_and_Brain.pdf http://irep.iium.edu.my/3883/4/Book.pdf
first_indexed	2023-09-18T20:11:52Z
last_indexed	2023-09-18T20:11:52Z
_version_	1777407531738464256

Dietary Zinc and the brain.

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