Particle formation and micronization using non-conventional techniques- review
Due to growing concerns regarding health, safety and the environment, non-conventional methods for particle formation and micronization that are either solvent-less or use environmentally acceptable solvents such as carbon dioxide have come into favor. Supercritical CO2 (sc CO2) (T > 31.1 '...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Elsevier B.V
2014
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/38952/ http://irep.iium.edu.my/38952/ http://irep.iium.edu.my/38952/1/JSF-paper-2014.pdf http://irep.iium.edu.my/38952/4/38952_Particle%20formation%20and%20micronization.SCOPUS.pdf |
| Summary: | Due to growing concerns regarding health, safety and the environment, non-conventional methods for
particle formation and micronization that are either solvent-less or use environmentally acceptable
solvents such as carbon dioxide have come into favor. Supercritical CO2 (sc CO2) (T > 31.1 'C, P > 7.3 MPa)
has been used in food and pharmaceutical industries to minimize the use of organic solvents, produce
new food products, produce environmentally superior food products and to process and micronize
(0.1–5mm) pharmaceuticals. Control of particle size increases the dissolution rate of drugs into the body.
Techniques that use sc CO2 eliminate inherent drawbacks of conventional methods such as thermal or
mechanical degradation of the product, poor control of the particle size and morphology, lack of
brittleness of some polymers and low encapsulation efficiency. Severaltechniques have been reported for
the particle formation and micronization using supercritical fluids that have been successfully scaled up
for commercial use. Supercritical CO2 has also been used to develop applications for medicines, essential
oils, vitamins, food grade polymers, catalysts and pigments. This review highlights the process
mechanism of supercritical fluid based techniques as well as some applications on particle formation and
micronization. |
|---|