The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production.
Context: Circadian variation is a fundamental characteristic of plasma glucocorticoids, with a postprandial rise in cortisol an important feature. The diurnal rhythm is presumed to reflect alterations in hypothalamic-pituitary- adrenal axis activity; however, cortisol is produced not only by the adr...
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The Endocrine Society
2014
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| Online Access: | http://irep.iium.edu.my/39441/ http://irep.iium.edu.my/39441/ http://irep.iium.edu.my/39441/ http://irep.iium.edu.my/39441/1/Stimson_%26_Mohd-Shukri_et_al._JCEM_2014._99._160-8.pdf |
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iium-394412014-12-02T07:28:20Z http://irep.iium.edu.my/39441/ The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production. Mohd Shukri, Nor Azwani Stimson, Roland H. Bolton, Jennifer L. Andrew, Ruth Reynolds, Rebecca M. Walker, Brian R. RA Public aspects of medicine Context: Circadian variation is a fundamental characteristic of plasma glucocorticoids, with a postprandial rise in cortisol an important feature. The diurnal rhythm is presumed to reflect alterations in hypothalamic-pituitary- adrenal axis activity; however, cortisol is produced not only by the adrenal glands but also by regeneration from cortisone by the enzyme 11β-hydroxysteroid dehydrogenase type 1, mainly in liver and adipose tissue. Objective: We tested the contribution of peripheral cortisol regeneration to macronutrient-induced circadian variation of plasma cortisol in humans. Design: This was a randomized, single-blinded, crossover study. Setting: The study was conducted at a hospital research facility. Participants: Eight normal-weight healthy men participated in the study. Interventions: Subjects were given isocaloric energy isodense flavor-matched liquid meals composed of carbohydrate, protein, fat, or low-calorie placebo during infusion of the stable isotope tracer 9,11,12,12-[2H]4-cortisol. Outcome Measures and Results: Plasma cortisol increased similarly after all macronutrient meals (by ∼90 nmol/L) compared with placebo. Carbohydrate stimulated adrenal secretion and extraadrenal regeneration of cortisol to a similar degree. Protein and fat meals stimulated adrenal cortisol secretion to a greater degree than extra-adrenal cortisol regeneration. The increase in cortisol production by 11β-hydroxysteroid dehydrogenase type 1 was in proportion to the increase in insulin. The postprandial cortisol rise was not accounted for by decreased cortisol clearance. Conclusions: Food-induced circadian variation in plasma cortisol is mediated by adrenal secretion and extra-adrenal regeneration of cortisol. Given that the latter has the more potent effect on tissue cortisol concentrations and that effects on adrenal and extra-adrenal cortisol production are macronutrient specific, this novel mechanism may contribute to the physiological interplay between insulin and glucocorticoids and the contrasting effects of certain diets on postprandial metabolism The Endocrine Society 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/39441/1/Stimson_%26_Mohd-Shukri_et_al._JCEM_2014._99._160-8.pdf Mohd Shukri, Nor Azwani and Stimson, Roland H. and Bolton, Jennifer L. and Andrew, Ruth and Reynolds, Rebecca M. and Walker, Brian R. (2014) The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production. Journal of Clinical Endocrinology and Metabolism, 99 (1). pp. 160-168. ISSN 0021-972X http://www.ncbi.nlm.nih.gov/pubmed/24092834 DOI: 10.1210/jc.2013-2307 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RA Public aspects of medicine |
| spellingShingle |
RA Public aspects of medicine Mohd Shukri, Nor Azwani Stimson, Roland H. Bolton, Jennifer L. Andrew, Ruth Reynolds, Rebecca M. Walker, Brian R. The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production. |
| description |
Context: Circadian variation is a fundamental characteristic of plasma glucocorticoids, with a postprandial rise in cortisol an important feature. The diurnal rhythm is presumed to reflect alterations in hypothalamic-pituitary- adrenal axis activity; however, cortisol is produced not only by the adrenal glands but also by regeneration from cortisone by the enzyme 11β-hydroxysteroid dehydrogenase type 1, mainly in liver and adipose tissue. Objective: We tested the contribution of peripheral cortisol regeneration to macronutrient-induced circadian variation of plasma cortisol in humans. Design: This was a randomized, single-blinded, crossover study. Setting: The study was conducted at a hospital research facility. Participants: Eight normal-weight healthy men participated in the study. Interventions: Subjects were given isocaloric energy isodense flavor-matched liquid meals composed of carbohydrate, protein, fat, or low-calorie placebo during infusion of the stable isotope tracer 9,11,12,12-[2H]4-cortisol. Outcome Measures and Results: Plasma cortisol increased similarly after all macronutrient meals (by ∼90 nmol/L) compared with placebo. Carbohydrate stimulated adrenal secretion and extraadrenal regeneration of cortisol to a similar degree. Protein and fat meals stimulated adrenal cortisol secretion to a greater degree than extra-adrenal cortisol regeneration. The increase in cortisol production by 11β-hydroxysteroid dehydrogenase type 1 was in proportion to the increase in insulin. The postprandial cortisol rise was not accounted for by decreased cortisol clearance. Conclusions: Food-induced circadian variation in plasma cortisol is mediated by adrenal secretion and extra-adrenal regeneration of cortisol. Given that the latter has the more potent effect on tissue cortisol concentrations and that effects on adrenal and extra-adrenal cortisol production are macronutrient specific, this novel mechanism may contribute to the physiological interplay between insulin and glucocorticoids and the contrasting effects of certain diets on postprandial metabolism |
| format |
Article |
| author |
Mohd Shukri, Nor Azwani Stimson, Roland H. Bolton, Jennifer L. Andrew, Ruth Reynolds, Rebecca M. Walker, Brian R. |
| author_facet |
Mohd Shukri, Nor Azwani Stimson, Roland H. Bolton, Jennifer L. Andrew, Ruth Reynolds, Rebecca M. Walker, Brian R. |
| author_sort |
Mohd Shukri, Nor Azwani |
| title |
The postprandial rise in plasma cortisol in men is
mediated by macronutrient-specific stimulation of
adrenal and extra-adrenal cortisol production. |
| title_short |
The postprandial rise in plasma cortisol in men is
mediated by macronutrient-specific stimulation of
adrenal and extra-adrenal cortisol production. |
| title_full |
The postprandial rise in plasma cortisol in men is
mediated by macronutrient-specific stimulation of
adrenal and extra-adrenal cortisol production. |
| title_fullStr |
The postprandial rise in plasma cortisol in men is
mediated by macronutrient-specific stimulation of
adrenal and extra-adrenal cortisol production. |
| title_full_unstemmed |
The postprandial rise in plasma cortisol in men is
mediated by macronutrient-specific stimulation of
adrenal and extra-adrenal cortisol production. |
| title_sort |
postprandial rise in plasma cortisol in men is
mediated by macronutrient-specific stimulation of
adrenal and extra-adrenal cortisol production. |
| publisher |
The Endocrine Society |
| publishDate |
2014 |
| url |
http://irep.iium.edu.my/39441/ http://irep.iium.edu.my/39441/ http://irep.iium.edu.my/39441/ http://irep.iium.edu.my/39441/1/Stimson_%26_Mohd-Shukri_et_al._JCEM_2014._99._160-8.pdf |
| first_indexed |
2023-09-18T20:56:40Z |
| last_indexed |
2023-09-18T20:56:40Z |
| _version_ |
1777410349909147648 |