Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan

Infective endocarditis (IE) remains a life threatening infection that is virtually always fatal if untreated. Despite advances in early diagnosis and treatment, several studies have reported an increase in the incidence of IE with notable changes in the nature of underlying cardiac disease. Degene...

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Main Authors:	Rathor, Mohammad Yousuf, How, Soon Hin, Abdul Rani, Mohd Fauzi, Shah, Asadullah
Format:	Article
Language:	English
Published:	National Databases of Indian Medical Journals 2006
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/39596/ http://irep.iium.edu.my/39596/ http://irep.iium.edu.my/39596/1/%28IE%292006.pdf

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recordtype	eprints
spelling	iium-395962015-01-18T04:37:58Z http://irep.iium.edu.my/39596/ Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan Rathor, Mohammad Yousuf How, Soon Hin Abdul Rani, Mohd Fauzi Shah, Asadullah RC Internal medicine Infective endocarditis (IE) remains a life threatening infection that is virtually always fatal if untreated. Despite advances in early diagnosis and treatment, several studies have reported an increase in the incidence of IE with notable changes in the nature of underlying cardiac disease. Degenerative, prosthetic, iatrogenic valvular disease and IE among intravenous drug users (IVDU) are now reported more frequently than rheumatic heart disease. The objective of this study was to determine the frequency of IE, its predisposing factors, microbiological status, and outcome at a state hospital in eastern Malaysia. Sixty seven inpatients diagnosed as IE or suspected IE from June 2000 till July 2002 were identified from hospital records out of which 45 cases that fulfilled the Duke criteria for diagnosis were included in the present study. The patients’ predisposing factors, clinical findings, complications, results of investigations and data on clinical outcome were extracted. There were 44 male and 1 female cases with a mean age of 31.9 years, of which 86.7% were IVDUs. Fifteen of our patients were HIV positive, all of whom were IVDU. There was no statistically .significant difference in bacteriology and echocardiography findings among HIV-positive and HIV-negative patients. Among IVDU, Staphylococcus aureus was the most common organism (61.5%) followed by streptococci (17.9%). Among non-IVDU, streptococci were isolated in 66.6 % cases, and Staphylococcus aureus in 1 case (16.6%). All cases were treated medically and median follow up was 6 months. A successful outcome was seen in 91% of patients. Conclusion: Intravenous drug use is the commonest predisposing factor for IE among our patients. National Databases of Indian Medical Journals 2006-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/39596/1/%28IE%292006.pdf Rathor, Mohammad Yousuf and How, Soon Hin and Abdul Rani, Mohd Fauzi and Shah, Asadullah (2006) Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan. JK-Practitioner, 13 (1). pp. 5-8. ISSN 0971-8834 http://medind.nic.in/jab/t06/i1/jabt06i1c.shtml
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Rathor, Mohammad Yousuf How, Soon Hin Abdul Rani, Mohd Fauzi Shah, Asadullah Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan
description	Infective endocarditis (IE) remains a life threatening infection that is virtually always fatal if untreated. Despite advances in early diagnosis and treatment, several studies have reported an increase in the incidence of IE with notable changes in the nature of underlying cardiac disease. Degenerative, prosthetic, iatrogenic valvular disease and IE among intravenous drug users (IVDU) are now reported more frequently than rheumatic heart disease. The objective of this study was to determine the frequency of IE, its predisposing factors, microbiological status, and outcome at a state hospital in eastern Malaysia. Sixty seven inpatients diagnosed as IE or suspected IE from June 2000 till July 2002 were identified from hospital records out of which 45 cases that fulfilled the Duke criteria for diagnosis were included in the present study. The patients’ predisposing factors, clinical findings, complications, results of investigations and data on clinical outcome were extracted. There were 44 male and 1 female cases with a mean age of 31.9 years, of which 86.7% were IVDUs. Fifteen of our patients were HIV positive, all of whom were IVDU. There was no statistically .significant difference in bacteriology and echocardiography findings among HIV-positive and HIV-negative patients. Among IVDU, Staphylococcus aureus was the most common organism (61.5%) followed by streptococci (17.9%). Among non-IVDU, streptococci were isolated in 66.6 % cases, and Staphylococcus aureus in 1 case (16.6%). All cases were treated medically and median follow up was 6 months. A successful outcome was seen in 91% of patients. Conclusion: Intravenous drug use is the commonest predisposing factor for IE among our patients.
format	Article
author	Rathor, Mohammad Yousuf How, Soon Hin Abdul Rani, Mohd Fauzi Shah, Asadullah
author_facet	Rathor, Mohammad Yousuf How, Soon Hin Abdul Rani, Mohd Fauzi Shah, Asadullah
author_sort	Rathor, Mohammad Yousuf
title	Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan
title_short	Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan
title_full	Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan
title_fullStr	Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan
title_full_unstemmed	Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan
title_sort	infective endocarditis in the east coast of peninsular malaysia: a two year retrospective survey from kuantan
publisher	National Databases of Indian Medical Journals
publishDate	2006
url	http://irep.iium.edu.my/39596/ http://irep.iium.edu.my/39596/ http://irep.iium.edu.my/39596/1/%28IE%292006.pdf
first_indexed	2023-09-18T20:56:54Z
last_indexed	2023-09-18T20:56:54Z
_version_	1777410365207871488

Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan

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