Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives
Natural coumarins are of great interest due to their widespread pharmacological properties and this makes them attractive for further backbone derivatization and screening them as several novel therapeutic agents. In this study, the presence of coumarin in Muraya koenigii leaves, Ocimum basilic...
| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/39615/ http://irep.iium.edu.my/39615/1/alif_edited_2.pdf http://irep.iium.edu.my/39615/4/39615_Screening%20of%20Muraya%20koenigii%2C%20Ocimum-abstract.pdf |
| Summary: | Natural coumarins are of great interest due to their widespread pharmacological properties
and this makes them attractive for further backbone derivatization and screening them as several
novel therapeutic agents. In this study, the presence of coumarin in Muraya koenigii leaves, Ocimum
basilicum leaves, and Jasminum sambac flowers, was screened. The samples were sourced locally and
then subjected to extraction process using different concentration of methanol and ethanol for
optimisation. Presence of coumarin was detected using thin layer chromatography (TLC) by comparing
against commercial standards of coumarin. Results were further analysed by measuring the retention
factor value (Rf) and estimating coumarin quantitatively using TLC Analyser. It was found that 95%
ethanol extraction produced the best yield of coumarin. Derivatives of coumarin found in Muraya
koenigii includes hydroxycoumarin and xanthotoxin, and in Ocimum basilicum includes
hydroxycoumarin, psoralen and xanthotoxin, whereas Jasminum sambac yielded xanthotoxin only. TLC
Analyser showed that the highest concentration of coumarin is contained in Muraya koenigii
suggesting it as a plant candidate for coumarin-lead compound targeting. |
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