Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives

Natural coumarins are of great interest due to their widespread pharmacological properties and this makes them attractive for further backbone derivatization and screening them as several novel therapeutic agents. In this study, the presence of coumarin in Muraya koenigii leaves, Ocimum basilic...

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Main Authors:	Mohd Shafri, Mohd Affendi, Abdul Salam, Muhammad Alif Nazruddin
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/39615/ http://irep.iium.edu.my/39615/1/alif_edited_2.pdf http://irep.iium.edu.my/39615/4/39615_Screening%20of%20Muraya%20koenigii%2C%20Ocimum-abstract.pdf

id	iium-39615
recordtype	eprints
spelling	iium-396152019-01-15T02:48:50Z http://irep.iium.edu.my/39615/ Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives Mohd Shafri, Mohd Affendi Abdul Salam, Muhammad Alif Nazruddin R Medicine (General) Natural coumarins are of great interest due to their widespread pharmacological properties and this makes them attractive for further backbone derivatization and screening them as several novel therapeutic agents. In this study, the presence of coumarin in Muraya koenigii leaves, Ocimum basilicum leaves, and Jasminum sambac flowers, was screened. The samples were sourced locally and then subjected to extraction process using different concentration of methanol and ethanol for optimisation. Presence of coumarin was detected using thin layer chromatography (TLC) by comparing against commercial standards of coumarin. Results were further analysed by measuring the retention factor value (Rf) and estimating coumarin quantitatively using TLC Analyser. It was found that 95% ethanol extraction produced the best yield of coumarin. Derivatives of coumarin found in Muraya koenigii includes hydroxycoumarin and xanthotoxin, and in Ocimum basilicum includes hydroxycoumarin, psoralen and xanthotoxin, whereas Jasminum sambac yielded xanthotoxin only. TLC Analyser showed that the highest concentration of coumarin is contained in Muraya koenigii suggesting it as a plant candidate for coumarin-lead compound targeting. 2014-12-03 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/39615/1/alif_edited_2.pdf application/pdf en http://irep.iium.edu.my/39615/4/39615_Screening%20of%20Muraya%20koenigii%2C%20Ocimum-abstract.pdf Mohd Shafri, Mohd Affendi and Abdul Salam, Muhammad Alif Nazruddin (2014) Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives. In: International Health Conference IIUM (IHCI) 2014, 3rd-4th Dec. 2014, Kuantan, Pahang. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mohd Shafri, Mohd Affendi Abdul Salam, Muhammad Alif Nazruddin Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives
description	Natural coumarins are of great interest due to their widespread pharmacological properties and this makes them attractive for further backbone derivatization and screening them as several novel therapeutic agents. In this study, the presence of coumarin in Muraya koenigii leaves, Ocimum basilicum leaves, and Jasminum sambac flowers, was screened. The samples were sourced locally and then subjected to extraction process using different concentration of methanol and ethanol for optimisation. Presence of coumarin was detected using thin layer chromatography (TLC) by comparing against commercial standards of coumarin. Results were further analysed by measuring the retention factor value (Rf) and estimating coumarin quantitatively using TLC Analyser. It was found that 95% ethanol extraction produced the best yield of coumarin. Derivatives of coumarin found in Muraya koenigii includes hydroxycoumarin and xanthotoxin, and in Ocimum basilicum includes hydroxycoumarin, psoralen and xanthotoxin, whereas Jasminum sambac yielded xanthotoxin only. TLC Analyser showed that the highest concentration of coumarin is contained in Muraya koenigii suggesting it as a plant candidate for coumarin-lead compound targeting.
format	Conference or Workshop Item
author	Mohd Shafri, Mohd Affendi Abdul Salam, Muhammad Alif Nazruddin
author_facet	Mohd Shafri, Mohd Affendi Abdul Salam, Muhammad Alif Nazruddin
author_sort	Mohd Shafri, Mohd Affendi
title	Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives
title_short	Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives
title_full	Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives
title_fullStr	Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives
title_full_unstemmed	Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives
title_sort	screening of muraya koenigii, ocimum basilicum and jasminum sambac for identification of coumarin and its derivatives
publishDate	2014
url	http://irep.iium.edu.my/39615/ http://irep.iium.edu.my/39615/1/alif_edited_2.pdf http://irep.iium.edu.my/39615/4/39615_Screening%20of%20Muraya%20koenigii%2C%20Ocimum-abstract.pdf
first_indexed	2023-09-18T20:56:56Z
last_indexed	2023-09-18T20:56:56Z
_version_	1777410366935924736

Screening of Muraya koenigii, Ocimum basilicum and Jasminum sambac for identification of coumarin and its derivatives

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