Cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed

Aqueous extracts obtained from five Malaysian brown seaweeds; Sargassum duplicatum, Sargassum binderi, Sargassum fulvellum, Padina australis and Turbinaria turbinata, were investigated for their abilities to inhibit Nitric oxide (NO) production in lipopolysaccharide (LPS) induced macrophage RAW 264....

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Main Authors:	Jaswir, Irwandi, Monsur, Hammed Ademola, Simsek, Senay, Amid, Azura, Alam, Md Zahangir, Salleh, Mohammad Noor, Tawakalit, Asiyanbi-Hammed, Octavianti, Fitri
Format:	Article
Language:	English English English
Published:	Japan Oil Chemists' Society 2014
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/39694/ http://irep.iium.edu.my/39694/ http://irep.iium.edu.my/39694/ http://irep.iium.edu.my/39694/4/cytotoxicity_and_inhibition_of_nitric.pdf http://irep.iium.edu.my/39694/7/52661-Cytotoxicity%20and%20inhibition%20of%20nitric%20oxide%20in%20lipopolysaccharide%20induced%20mammalian%20_SCOPUS.pdf http://irep.iium.edu.my/39694/8/52661-Cytotoxicity%20and%20inhibition%20of%20nitric%20oxide%20in%20lipopolysaccharide%20induced%20mammalian%20_WOS.pdf

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spelling	iium-396942017-08-03T07:24:14Z http://irep.iium.edu.my/39694/ Cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed Jaswir, Irwandi Monsur, Hammed Ademola Simsek, Senay Amid, Azura Alam, Md Zahangir Salleh, Mohammad Noor Tawakalit, Asiyanbi-Hammed Octavianti, Fitri QD Chemistry Aqueous extracts obtained from five Malaysian brown seaweeds; Sargassum duplicatum, Sargassum binderi, Sargassum fulvellum, Padina australis and Turbinaria turbinata, were investigated for their abilities to inhibit Nitric oxide (NO) production in lipopolysaccharide (LPS) induced macrophage RAW 264.7 cell lines as well as their chemical composition. Percentage yield of extracts varied among species, with the least yield in P. australis and highest yield in T. turbinata. The chemical compositions of the extracts showed that percentage sulfate ion, uronic acid and total sugar contents vary remarkably. All extracts contain high fucose and inhibit NO secretion in a dose dependent manner. Percentage of NO inhibition correlates very well with uronic acid content of the extract. Extracts of P. australis and T. turbinata dosed as 200 g/ml where able to cause >75% NO inhibition. Cytotoxicity assay revealed that some extracts were moderately toxic while some are not. Brown seaweed of Malaysian origin can be further explored for additional anti-inflammatory biocompounds. Japan Oil Chemists' Society 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/39694/4/cytotoxicity_and_inhibition_of_nitric.pdf application/pdf en http://irep.iium.edu.my/39694/7/52661-Cytotoxicity%20and%20inhibition%20of%20nitric%20oxide%20in%20lipopolysaccharide%20induced%20mammalian%20_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/39694/8/52661-Cytotoxicity%20and%20inhibition%20of%20nitric%20oxide%20in%20lipopolysaccharide%20induced%20mammalian%20_WOS.pdf Jaswir, Irwandi and Monsur, Hammed Ademola and Simsek, Senay and Amid, Azura and Alam, Md Zahangir and Salleh, Mohammad Noor and Tawakalit, Asiyanbi-Hammed and Octavianti, Fitri (2014) Cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed. Journal of Oleo Science, 63 (8). pp. 787-794. ISSN 1345-8957 E-ISSN 1347-3352 https://www.jstage.jst.go.jp/article/jos/63/8/63_ess13185/_pdf 10.5650/jos.ess13185
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QD Chemistry
spellingShingle	QD Chemistry Jaswir, Irwandi Monsur, Hammed Ademola Simsek, Senay Amid, Azura Alam, Md Zahangir Salleh, Mohammad Noor Tawakalit, Asiyanbi-Hammed Octavianti, Fitri Cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed
description	Aqueous extracts obtained from five Malaysian brown seaweeds; Sargassum duplicatum, Sargassum binderi, Sargassum fulvellum, Padina australis and Turbinaria turbinata, were investigated for their abilities to inhibit Nitric oxide (NO) production in lipopolysaccharide (LPS) induced macrophage RAW 264.7 cell lines as well as their chemical composition. Percentage yield of extracts varied among species, with the least yield in P. australis and highest yield in T. turbinata. The chemical compositions of the extracts showed that percentage sulfate ion, uronic acid and total sugar contents vary remarkably. All extracts contain high fucose and inhibit NO secretion in a dose dependent manner. Percentage of NO inhibition correlates very well with uronic acid content of the extract. Extracts of P. australis and T. turbinata dosed as 200 g/ml where able to cause >75% NO inhibition. Cytotoxicity assay revealed that some extracts were moderately toxic while some are not. Brown seaweed of Malaysian origin can be further explored for additional anti-inflammatory biocompounds.
format	Article
author	Jaswir, Irwandi Monsur, Hammed Ademola Simsek, Senay Amid, Azura Alam, Md Zahangir Salleh, Mohammad Noor Tawakalit, Asiyanbi-Hammed Octavianti, Fitri
author_facet	Jaswir, Irwandi Monsur, Hammed Ademola Simsek, Senay Amid, Azura Alam, Md Zahangir Salleh, Mohammad Noor Tawakalit, Asiyanbi-Hammed Octavianti, Fitri
author_sort	Jaswir, Irwandi
title	Cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed
title_short	Cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed
title_full	Cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed
title_fullStr	Cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed
title_full_unstemmed	Cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed
title_sort	cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed
publisher	Japan Oil Chemists' Society
publishDate	2014
url	http://irep.iium.edu.my/39694/ http://irep.iium.edu.my/39694/ http://irep.iium.edu.my/39694/ http://irep.iium.edu.my/39694/4/cytotoxicity_and_inhibition_of_nitric.pdf http://irep.iium.edu.my/39694/7/52661-Cytotoxicity%20and%20inhibition%20of%20nitric%20oxide%20in%20lipopolysaccharide%20induced%20mammalian%20_SCOPUS.pdf http://irep.iium.edu.my/39694/8/52661-Cytotoxicity%20and%20inhibition%20of%20nitric%20oxide%20in%20lipopolysaccharide%20induced%20mammalian%20_WOS.pdf
first_indexed	2023-09-18T20:57:02Z
last_indexed	2023-09-18T20:57:02Z
_version_	1777410373302878208

Cytotoxicity and inhibition of nitric oxide in lipopolysaccharide induced mammalian cell lines by aqueous extracts of brown seaweed

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