Late Follicular Hyperprolactinemia (LF-HPRL) is not a disease

Prolactin (PRL) is an exceptional hormone of pituitary gland with important implications for normal reproduction as well as for sexual behavior. It increases in the first trimester of pregnancy (physiological hyperprolactinemia). The objective of this study is to evaluate the effectiveness of LF-HPR...

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Main Authors:	Allow, Ahmed Kaid Naji, Sadek S. M., Abdulmogny, Bracamonte, Maryam, Belqees, Ahmed Kaid
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	RG Gynecology and obstetrics
Online Access:	http://irep.iium.edu.my/39731/ http://irep.iium.edu.my/39731/1/39731_abstract.pdf http://irep.iium.edu.my/39731/2/39731_poster.pdf

id	iium-39731
recordtype	eprints
spelling	iium-397312017-03-28T03:56:48Z http://irep.iium.edu.my/39731/ Late Follicular Hyperprolactinemia (LF-HPRL) is not a disease Allow, Ahmed Kaid Naji Sadek S. M., Abdulmogny Bracamonte, Maryam Belqees, Ahmed Kaid RG Gynecology and obstetrics Prolactin (PRL) is an exceptional hormone of pituitary gland with important implications for normal reproduction as well as for sexual behavior. It increases in the first trimester of pregnancy (physiological hyperprolactinemia). The objective of this study is to evaluate the effectiveness of LF-HPRL as an indicator for early ongoing pregnancy in patients undergoing infertility treatment. Materials and patients: One hundred and eleven infertile women were involved in the present study. They were divided into: group A=76 pregnant women without anti-LF-HPRL therapy and 35 pregnant women with anti- LF-HPRL therapy as a group B. All women in both groups had been treated due to hyperprolactinemia until their PRL levels were normal. Later, after one cycle, both groups had been enrolled in a controlled ovarian hyperstimulation (COS). Their husbands were reproductively fertile. All women with an additional factor of infertility had been excluded. The COS was aimed to get 2-3 mature follicles/women/cycle. During study, the ovulation, pregnancy, abortion, cancelation and live-birth rates were evaluated. Results: no significant differences between the groups regarding age, BMI and baseline hormonal investigation (FSH, LH, LH/FSH, testosterone, estradiol and PRL (P<0.03). The progesterone level at the day 21 of cycle was significantly difference between study and control groups, (4.52±4.91 and 5.36±4.73, respectively, P<0.02). The serum PRL at the 28 day of ovulation induction cycle was significantly difference between study and control group (28.32±11.89 and 7.53±5.69, respectively, P<0.001). The ovulation, ongoing pregnancy, life-birth rates were significantly higher in study group in compare to control group (P<0.001). The early abortion and cancelation rates were significantly higher in control in compare to study groups (P<0.001). Conclusion: high level of serum prolactin levels in the late follicular menstrual phase or LF-HPRL in infertile women treated by ovulation induction after complete hyperplactinemic therapy could be used as an indicator for early pregnancy. Treatment of LF-HPRL not recommended. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/39731/1/39731_abstract.pdf application/pdf en http://irep.iium.edu.my/39731/2/39731_poster.pdf Allow, Ahmed Kaid Naji and Sadek S. M., Abdulmogny and Bracamonte, Maryam and Belqees, Ahmed Kaid (2014) Late Follicular Hyperprolactinemia (LF-HPRL) is not a disease. In: International Health Conference IIUM 2014, 3rd-4th Dec 2014, Kuantan, Pahang. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Allow, Ahmed Kaid Naji Sadek S. M., Abdulmogny Bracamonte, Maryam Belqees, Ahmed Kaid Late Follicular Hyperprolactinemia (LF-HPRL) is not a disease
description	Prolactin (PRL) is an exceptional hormone of pituitary gland with important implications for normal reproduction as well as for sexual behavior. It increases in the first trimester of pregnancy (physiological hyperprolactinemia). The objective of this study is to evaluate the effectiveness of LF-HPRL as an indicator for early ongoing pregnancy in patients undergoing infertility treatment. Materials and patients: One hundred and eleven infertile women were involved in the present study. They were divided into: group A=76 pregnant women without anti-LF-HPRL therapy and 35 pregnant women with anti- LF-HPRL therapy as a group B. All women in both groups had been treated due to hyperprolactinemia until their PRL levels were normal. Later, after one cycle, both groups had been enrolled in a controlled ovarian hyperstimulation (COS). Their husbands were reproductively fertile. All women with an additional factor of infertility had been excluded. The COS was aimed to get 2-3 mature follicles/women/cycle. During study, the ovulation, pregnancy, abortion, cancelation and live-birth rates were evaluated. Results: no significant differences between the groups regarding age, BMI and baseline hormonal investigation (FSH, LH, LH/FSH, testosterone, estradiol and PRL (P<0.03). The progesterone level at the day 21 of cycle was significantly difference between study and control groups, (4.52±4.91 and 5.36±4.73, respectively, P<0.02). The serum PRL at the 28 day of ovulation induction cycle was significantly difference between study and control group (28.32±11.89 and 7.53±5.69, respectively, P<0.001). The ovulation, ongoing pregnancy, life-birth rates were significantly higher in study group in compare to control group (P<0.001). The early abortion and cancelation rates were significantly higher in control in compare to study groups (P<0.001). Conclusion: high level of serum prolactin levels in the late follicular menstrual phase or LF-HPRL in infertile women treated by ovulation induction after complete hyperplactinemic therapy could be used as an indicator for early pregnancy. Treatment of LF-HPRL not recommended.
format	Conference or Workshop Item
author	Allow, Ahmed Kaid Naji Sadek S. M., Abdulmogny Bracamonte, Maryam Belqees, Ahmed Kaid
author_facet	Allow, Ahmed Kaid Naji Sadek S. M., Abdulmogny Bracamonte, Maryam Belqees, Ahmed Kaid
author_sort	Allow, Ahmed Kaid Naji
title	Late Follicular Hyperprolactinemia (LF-HPRL) is not a disease
title_short	Late Follicular Hyperprolactinemia (LF-HPRL) is not a disease
title_full	Late Follicular Hyperprolactinemia (LF-HPRL) is not a disease
title_fullStr	Late Follicular Hyperprolactinemia (LF-HPRL) is not a disease
title_full_unstemmed	Late Follicular Hyperprolactinemia (LF-HPRL) is not a disease
title_sort	late follicular hyperprolactinemia (lf-hprl) is not a disease
publishDate	2014
url	http://irep.iium.edu.my/39731/ http://irep.iium.edu.my/39731/1/39731_abstract.pdf http://irep.iium.edu.my/39731/2/39731_poster.pdf
first_indexed	2023-09-18T20:57:05Z
last_indexed	2023-09-18T20:57:05Z
_version_	1777410376356331520

Late Follicular Hyperprolactinemia (LF-HPRL) is not a disease

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