Evaluation of antimalaria activity and acute toxicity of xetospongia sp

We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and establ...

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Main Authors:	Abdillah, Syamsudin, Ahmad, Rahmatul Wahidah, Parama Cita, Yatnita, Mohd Noor, Noriah
Format:	Article
Language:	English
Published:	Science Publications 2013
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/39966/ http://irep.iium.edu.my/39966/ http://irep.iium.edu.my/39966/ http://irep.iium.edu.my/39966/1/ajptsp.2013.83.88.pdf

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recordtype	eprints
spelling	iium-399662014-12-16T03:18:09Z http://irep.iium.edu.my/39966/ Evaluation of antimalaria activity and acute toxicity of xetospongia sp Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Parama Cita, Yatnita Mohd Noor, Noriah RC Internal medicine We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute toxicity of extracts of Xetospongia sp at the dose 5000 mg kg-1 on mice administeredorally exhibited no toxicity, as evident in that fact that no histopathological changes were observed in some essential organs, such as liver, heart, digestive tract and kidney. The ethanolic extracts (50-400 mg kg day-1) exhibited a significant antimalarial activity both in the 4-day early infection test and in the established infection and they were found to be relatively safe up to a dosage of 5000 mg kg-1, with an LD50 value of >500 mg kg-1. Science Publications 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/39966/1/ajptsp.2013.83.88.pdf Abdillah, Syamsudin and Ahmad, Rahmatul Wahidah and Parama Cita, Yatnita and Mohd Noor, Noriah (2013) Evaluation of antimalaria activity and acute toxicity of xetospongia sp. American Journal of Pharmacology and Toxicology , 8 (2). pp. 83-88. ISSN 1557-4962 http://thescipub.com/abstract/10.3844/ajptsp.2013.83.88 10.3844/ajptsp.2013.83.88
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Parama Cita, Yatnita Mohd Noor, Noriah Evaluation of antimalaria activity and acute toxicity of xetospongia sp
description	We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute toxicity of extracts of Xetospongia sp at the dose 5000 mg kg-1 on mice administeredorally exhibited no toxicity, as evident in that fact that no histopathological changes were observed in some essential organs, such as liver, heart, digestive tract and kidney. The ethanolic extracts (50-400 mg kg day-1) exhibited a significant antimalarial activity both in the 4-day early infection test and in the established infection and they were found to be relatively safe up to a dosage of 5000 mg kg-1, with an LD50 value of >500 mg kg-1.
format	Article
author	Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Parama Cita, Yatnita Mohd Noor, Noriah
author_facet	Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Parama Cita, Yatnita Mohd Noor, Noriah
author_sort	Abdillah, Syamsudin
title	Evaluation of antimalaria activity and acute toxicity of xetospongia sp
title_short	Evaluation of antimalaria activity and acute toxicity of xetospongia sp
title_full	Evaluation of antimalaria activity and acute toxicity of xetospongia sp
title_fullStr	Evaluation of antimalaria activity and acute toxicity of xetospongia sp
title_full_unstemmed	Evaluation of antimalaria activity and acute toxicity of xetospongia sp
title_sort	evaluation of antimalaria activity and acute toxicity of xetospongia sp
publisher	Science Publications
publishDate	2013
url	http://irep.iium.edu.my/39966/ http://irep.iium.edu.my/39966/ http://irep.iium.edu.my/39966/ http://irep.iium.edu.my/39966/1/ajptsp.2013.83.88.pdf
first_indexed	2023-09-18T20:57:22Z
last_indexed	2023-09-18T20:57:22Z
_version_	1777410394299564032

Evaluation of antimalaria activity and acute toxicity of xetospongia sp

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