Microscopic diffusion properties of fixed breast tissue: preliminary findings

Microscopic diffusion properties of fixed breast tissue: preliminary findings

Purpose: To investigate the microscopic diffusion properties of formalin-fixed breast tissue. Methods: Diffusion microimaging was performed at 16.4T with 40-mm isotropic voxels on two normal and two cancer tissue samples from four patients. Results were correlated with histology of the samples....

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Main Authors: Norddin, Narina, Power, Carl, Watson, Geoffrey, Cowin, Gary, Kurniawan, Nyoman, Gluch, Laurence, Bourne, Roger
Format: Article
Language:English
English
Published: Wiley 2014
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/40078/
http://irep.iium.edu.my/40078/
http://irep.iium.edu.my/40078/
http://irep.iium.edu.my/40078/1/MRM-_Decision_on_Manuscript_-_Narina_Norddin.pdf
http://irep.iium.edu.my/40078/2/Norddin_et_al_2014_.pdf
id iium-40078
recordtype eprints
spelling iium-400782018-05-23T03:28:46Z http://irep.iium.edu.my/40078/ Microscopic diffusion properties of fixed breast tissue: preliminary findings Norddin, Narina Power, Carl Watson, Geoffrey Cowin, Gary Kurniawan, Nyoman Gluch, Laurence Bourne, Roger R Medicine (General) Purpose: To investigate the microscopic diffusion properties of formalin-fixed breast tissue. Methods: Diffusion microimaging was performed at 16.4T with 40-mm isotropic voxels on two normal and two cancer tissue samples from four patients. Results were correlated with histology of the samples. Results: Diffusion-weighted images and mean diffusivity maps demonstrated distinct diffusivity differences between breast tissue components. Mean diffusivity (MD) in normal tissue was 0.5960.24 mm2/ms for gland lobule (voxels containing epithelium and intralobular stroma) and 1.2360.34 mm2/ms for interlobular fibrous stroma. In the cancer samples, MD¼0.4560.23 mm2/ms for invasive ductal carcinoma (voxels contain epithelium and intralobular stroma) and 0.6160.35 mm2/ms for ductal carcinoma in situ. There were significant MD differences between all tissue components (P<0.005), except between gland lobule and ductal carcinoma in situ (P¼0.71). The low diffusivity of epithelium-rich cancer tissue and of normal epithelium relative to its supporting fibrous stroma was similar to that reported for prostate tissue and the esophageal wall. Conclusion: Diffusion microimaging demonstrates distinct diffusivity differences between breast tissue glandular structures. Low diffusivity may be a distinctive feature of mammalian epithelia. Wiley 2014-12-17 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40078/1/MRM-_Decision_on_Manuscript_-_Narina_Norddin.pdf application/pdf en http://irep.iium.edu.my/40078/2/Norddin_et_al_2014_.pdf Norddin, Narina and Power, Carl and Watson, Geoffrey and Cowin, Gary and Kurniawan, Nyoman and Gluch, Laurence and Bourne, Roger (2014) Microscopic diffusion properties of fixed breast tissue: preliminary findings. Magnetic Resonance in Medicine, xx (xx). pp. 1-7. (In Press) http://onlinelibrary.wiley.com/doi/10.1002/mrm.25555/abstract 10.1002/mrm.25555
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Norddin, Narina
Power, Carl
Watson, Geoffrey
Cowin, Gary
Kurniawan, Nyoman
Gluch, Laurence
Bourne, Roger
Microscopic diffusion properties of fixed breast tissue: preliminary findings
description Purpose: To investigate the microscopic diffusion properties of formalin-fixed breast tissue. Methods: Diffusion microimaging was performed at 16.4T with 40-mm isotropic voxels on two normal and two cancer tissue samples from four patients. Results were correlated with histology of the samples. Results: Diffusion-weighted images and mean diffusivity maps demonstrated distinct diffusivity differences between breast tissue components. Mean diffusivity (MD) in normal tissue was 0.5960.24 mm2/ms for gland lobule (voxels containing epithelium and intralobular stroma) and 1.2360.34 mm2/ms for interlobular fibrous stroma. In the cancer samples, MD¼0.4560.23 mm2/ms for invasive ductal carcinoma (voxels contain epithelium and intralobular stroma) and 0.6160.35 mm2/ms for ductal carcinoma in situ. There were significant MD differences between all tissue components (P<0.005), except between gland lobule and ductal carcinoma in situ (P¼0.71). The low diffusivity of epithelium-rich cancer tissue and of normal epithelium relative to its supporting fibrous stroma was similar to that reported for prostate tissue and the esophageal wall. Conclusion: Diffusion microimaging demonstrates distinct diffusivity differences between breast tissue glandular structures. Low diffusivity may be a distinctive feature of mammalian epithelia.
format Article
author Norddin, Narina
Power, Carl
Watson, Geoffrey
Cowin, Gary
Kurniawan, Nyoman
Gluch, Laurence
Bourne, Roger
author_facet Norddin, Narina
Power, Carl
Watson, Geoffrey
Cowin, Gary
Kurniawan, Nyoman
Gluch, Laurence
Bourne, Roger
author_sort Norddin, Narina
title Microscopic diffusion properties of fixed breast tissue: preliminary findings
title_short Microscopic diffusion properties of fixed breast tissue: preliminary findings
title_full Microscopic diffusion properties of fixed breast tissue: preliminary findings
title_fullStr Microscopic diffusion properties of fixed breast tissue: preliminary findings
title_full_unstemmed Microscopic diffusion properties of fixed breast tissue: preliminary findings
title_sort microscopic diffusion properties of fixed breast tissue: preliminary findings
publisher Wiley
publishDate 2014
url http://irep.iium.edu.my/40078/
http://irep.iium.edu.my/40078/
http://irep.iium.edu.my/40078/
http://irep.iium.edu.my/40078/1/MRM-_Decision_on_Manuscript_-_Narina_Norddin.pdf
http://irep.iium.edu.my/40078/2/Norddin_et_al_2014_.pdf
first_indexed 2023-09-18T20:57:30Z
last_indexed 2023-09-18T20:57:30Z
_version_ 1777410402907324416

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