Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats
Introduction: To investigate the neuroprotective potential of Malaysian Tualang honey in chronic cerebral hypoperfusion induced by permanent bilateral common carotid arteries ligation (2VO) in rats. Methods: Rats were randomly divided into three groups (n ¼ 10); sham control, honeyuntreated 2VO...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Anatomical Society of India.
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/40353/ http://irep.iium.edu.my/40353/1/Potential_protective_effect_of_honey.pdf |
| Summary: | Introduction: To investigate the neuroprotective potential of Malaysian Tualang honey in
chronic cerebral hypoperfusion induced by permanent bilateral common carotid arteries
ligation (2VO) in rats.
Methods: Rats were randomly divided into three groups (n ¼ 10); sham control, honeyuntreated
2VO group “2VO” and honey treated 2VO group “2VO þ H”. At 10th week of
2VO surgery, all the rat were sacrificed, brains were dissected out, the right hemisphere
was processed for histological study, neuronal counts were performed on cresyl violetstained
sections, the number of viable neurons in CA-1 region of the hippocampus were
analysed and counted.
Results: There were damaged, distorted, irregular cells with shrunken cytoplasm and dark
pykonotic nuclei in “2VO” rats. Treatment of rats with honey restored the hippocampal
cells to their normal structure and reduced loss of neurons in “2VO þ H” rats as compared
with “2VO” rats.
Discussion: This study shows that Malaysian Tualang honey might have therapeutic potential
for the treatment of chronic cerebral hypoperfusion related neurodegenerative
disorders |
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