Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats

Introduction: To investigate the neuroprotective potential of Malaysian Tualang honey in chronic cerebral hypoperfusion induced by permanent bilateral common carotid arteries ligation (2VO) in rats. Methods: Rats were randomly divided into three groups (n ¼ 10); sham control, honeyuntreated 2VO...

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Main Authors: Saxena, Anil Kumar, Phyu, Hnin P., Al-Ani, Imad Matloub Dally, Talib, Norlelawati A.
Format: Article
Language:English
Published: Anatomical Society of India. 2014
Subjects:
Online Access:http://irep.iium.edu.my/40353/
http://irep.iium.edu.my/40353/1/Potential_protective_effect_of_honey.pdf
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spelling iium-403532018-05-23T07:04:12Z http://irep.iium.edu.my/40353/ Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats Saxena, Anil Kumar Phyu, Hnin P. Al-Ani, Imad Matloub Dally Talib, Norlelawati A. QM Human anatomy QP Physiology RB Pathology RM214 Diet therapy. Diet and dietectics in disease RM300 Drugs and their action Introduction: To investigate the neuroprotective potential of Malaysian Tualang honey in chronic cerebral hypoperfusion induced by permanent bilateral common carotid arteries ligation (2VO) in rats. Methods: Rats were randomly divided into three groups (n ¼ 10); sham control, honeyuntreated 2VO group “2VO” and honey treated 2VO group “2VO þ H”. At 10th week of 2VO surgery, all the rat were sacrificed, brains were dissected out, the right hemisphere was processed for histological study, neuronal counts were performed on cresyl violetstained sections, the number of viable neurons in CA-1 region of the hippocampus were analysed and counted. Results: There were damaged, distorted, irregular cells with shrunken cytoplasm and dark pykonotic nuclei in “2VO” rats. Treatment of rats with honey restored the hippocampal cells to their normal structure and reduced loss of neurons in “2VO þ H” rats as compared with “2VO” rats. Discussion: This study shows that Malaysian Tualang honey might have therapeutic potential for the treatment of chronic cerebral hypoperfusion related neurodegenerative disorders Anatomical Society of India. 2014-12-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40353/1/Potential_protective_effect_of_honey.pdf Saxena, Anil Kumar and Phyu, Hnin P. and Al-Ani, Imad Matloub Dally and Talib, Norlelawati A. (2014) Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats. Journal of the Anatomical Society of India, 63 (Sp iss). pp. 151-155. ISSN 0003-2778 (In Press)
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QM Human anatomy
QP Physiology
RB Pathology
RM214 Diet therapy. Diet and dietectics in disease
RM300 Drugs and their action
spellingShingle QM Human anatomy
QP Physiology
RB Pathology
RM214 Diet therapy. Diet and dietectics in disease
RM300 Drugs and their action
Saxena, Anil Kumar
Phyu, Hnin P.
Al-Ani, Imad Matloub Dally
Talib, Norlelawati A.
Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats
description Introduction: To investigate the neuroprotective potential of Malaysian Tualang honey in chronic cerebral hypoperfusion induced by permanent bilateral common carotid arteries ligation (2VO) in rats. Methods: Rats were randomly divided into three groups (n ¼ 10); sham control, honeyuntreated 2VO group “2VO” and honey treated 2VO group “2VO þ H”. At 10th week of 2VO surgery, all the rat were sacrificed, brains were dissected out, the right hemisphere was processed for histological study, neuronal counts were performed on cresyl violetstained sections, the number of viable neurons in CA-1 region of the hippocampus were analysed and counted. Results: There were damaged, distorted, irregular cells with shrunken cytoplasm and dark pykonotic nuclei in “2VO” rats. Treatment of rats with honey restored the hippocampal cells to their normal structure and reduced loss of neurons in “2VO þ H” rats as compared with “2VO” rats. Discussion: This study shows that Malaysian Tualang honey might have therapeutic potential for the treatment of chronic cerebral hypoperfusion related neurodegenerative disorders
format Article
author Saxena, Anil Kumar
Phyu, Hnin P.
Al-Ani, Imad Matloub Dally
Talib, Norlelawati A.
author_facet Saxena, Anil Kumar
Phyu, Hnin P.
Al-Ani, Imad Matloub Dally
Talib, Norlelawati A.
author_sort Saxena, Anil Kumar
title Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_short Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_full Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_fullStr Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_full_unstemmed Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_sort potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats
publisher Anatomical Society of India.
publishDate 2014
url http://irep.iium.edu.my/40353/
http://irep.iium.edu.my/40353/1/Potential_protective_effect_of_honey.pdf
first_indexed 2023-09-18T20:57:53Z
last_indexed 2023-09-18T20:57:53Z
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