The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma.

Purpose: To investigate the relationship between Doppler SD-OCT derived retinal blood flow (RBF) and the retinal nerve fiber layer (RNFL) thickness in patients with primary open angle glaucoma (POAG) and healthy age-matched controls. Methods: Thirty three POAG patients (age, 65±8 years; Humphrey Fi...

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Main Authors:	Flanagan, John G, Yusof, Firdaus, Cheng, Richard, Tayyari, Faryan, Espahbodi, Nadia, Khuu, Lee-Anne, Buys, Yvonne M, Trope, Graham, Hudson, Christopher
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	RE Ophthalmology
Online Access:	http://irep.iium.edu.my/40378/ http://irep.iium.edu.my/40378/1/Abstract_FYA_JF_ARVO_2014.pdf http://irep.iium.edu.my/40378/4/ARVO_frontf_2014.pdf

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recordtype	eprints
spelling	iium-403782015-08-04T00:42:34Z http://irep.iium.edu.my/40378/ The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. Flanagan, John G Yusof, Firdaus Cheng, Richard Tayyari, Faryan Espahbodi, Nadia Khuu, Lee-Anne Buys, Yvonne M Trope, Graham Hudson, Christopher RE Ophthalmology Purpose: To investigate the relationship between Doppler SD-OCT derived retinal blood flow (RBF) and the retinal nerve fiber layer (RNFL) thickness in patients with primary open angle glaucoma (POAG) and healthy age-matched controls. Methods: Thirty three POAG patients (age, 65±8 years; Humphrey Field Analyzer, HFA, mean deviation, MD, -2.28±3.85) and 33 healthy controls (age, 63±5 years; HFA MD -0.48±1.56) were recruited. The Doppler SD-OCT retinal blood flow measurement was taken using the circum-papillary double circular scan protocol in the RTVue system (Optovue Inc., Freemont, CA, USA). A minimum of six RBF scans were acquired. Flow parameters were calculated only from the valid scans. Peri-papillary RNFL thickness was measured using RTVue’s RNFL scan protocol. Results: The total RBF in the POAG group was significantly lower than in the control group (group mean POAG RBF = 30.61±9.29mL/min; group mean control RBF = 40.68±11.32mL/min; p=<0.01). Superior and inferior RBF were also significantly lower in the POAG group (p=<0.01 for both superior & inferior RBF). The average RNFL thickness, superior and inferior RNFL thickness were significantly lower in the POAG group (p=<0.01). Linear regression analysis showed a significant positive correlation between the total RBF and average RNFL thickness (r=0.38, p=0.03), and the superior RBF and superior RNFL thickness (r=0.37, p=0.01). There was no correlation between the inferior RBF and RNFL thickness (r=0.30,p=0.09). Conclusions: There was an association between thinning of the RNFL and reduced inner retinal perfusion in the eyes of patients with POAG. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/40378/1/Abstract_FYA_JF_ARVO_2014.pdf application/pdf en http://irep.iium.edu.my/40378/4/ARVO_frontf_2014.pdf Flanagan, John G and Yusof, Firdaus and Cheng, Richard and Tayyari, Faryan and Espahbodi, Nadia and Khuu, Lee-Anne and Buys, Yvonne M and Trope, Graham and Hudson, Christopher (2014) The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. In: ARVO 2014, May 4 – 8, 2014, Orlando, FL, USA. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Flanagan, John G Yusof, Firdaus Cheng, Richard Tayyari, Faryan Espahbodi, Nadia Khuu, Lee-Anne Buys, Yvonne M Trope, Graham Hudson, Christopher The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma.
description	Purpose: To investigate the relationship between Doppler SD-OCT derived retinal blood flow (RBF) and the retinal nerve fiber layer (RNFL) thickness in patients with primary open angle glaucoma (POAG) and healthy age-matched controls. Methods: Thirty three POAG patients (age, 65±8 years; Humphrey Field Analyzer, HFA, mean deviation, MD, -2.28±3.85) and 33 healthy controls (age, 63±5 years; HFA MD -0.48±1.56) were recruited. The Doppler SD-OCT retinal blood flow measurement was taken using the circum-papillary double circular scan protocol in the RTVue system (Optovue Inc., Freemont, CA, USA). A minimum of six RBF scans were acquired. Flow parameters were calculated only from the valid scans. Peri-papillary RNFL thickness was measured using RTVue’s RNFL scan protocol. Results: The total RBF in the POAG group was significantly lower than in the control group (group mean POAG RBF = 30.61±9.29mL/min; group mean control RBF = 40.68±11.32mL/min; p=<0.01). Superior and inferior RBF were also significantly lower in the POAG group (p=<0.01 for both superior & inferior RBF). The average RNFL thickness, superior and inferior RNFL thickness were significantly lower in the POAG group (p=<0.01). Linear regression analysis showed a significant positive correlation between the total RBF and average RNFL thickness (r=0.38, p=0.03), and the superior RBF and superior RNFL thickness (r=0.37, p=0.01). There was no correlation between the inferior RBF and RNFL thickness (r=0.30,p=0.09). Conclusions: There was an association between thinning of the RNFL and reduced inner retinal perfusion in the eyes of patients with POAG.
format	Conference or Workshop Item
author	Flanagan, John G Yusof, Firdaus Cheng, Richard Tayyari, Faryan Espahbodi, Nadia Khuu, Lee-Anne Buys, Yvonne M Trope, Graham Hudson, Christopher
author_facet	Flanagan, John G Yusof, Firdaus Cheng, Richard Tayyari, Faryan Espahbodi, Nadia Khuu, Lee-Anne Buys, Yvonne M Trope, Graham Hudson, Christopher
author_sort	Flanagan, John G
title	The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma.
title_short	The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma.
title_full	The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma.
title_fullStr	The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma.
title_full_unstemmed	The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma.
title_sort	relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma.
publishDate	2014
url	http://irep.iium.edu.my/40378/ http://irep.iium.edu.my/40378/1/Abstract_FYA_JF_ARVO_2014.pdf http://irep.iium.edu.my/40378/4/ARVO_frontf_2014.pdf
first_indexed	2023-09-18T20:57:55Z
last_indexed	2023-09-18T20:57:55Z
_version_	1777410428925640704

The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma.

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