Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains

The incidence of epidemics due to drug resistant bacteria had posed public health concern. Thus, a novel antibacterial approach to synergize antibiotics in combination with essential oils of selected zingiberaceae plants was chosen in this study to aid in increasing the susceptibility of bacteria. T...

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Main Authors:	Mohammad Yaqoob Akhtar, Nabilah, Darnis, Deny Susanti
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/40508/ http://irep.iium.edu.my/40508/2/Slide%2C_Biomedical_Sympo_2014.pdf http://irep.iium.edu.my/40508/5/bacterial_strains.pdf

id	iium-40508
recordtype	eprints
spelling	iium-405082015-01-06T03:11:08Z http://irep.iium.edu.my/40508/ Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains Mohammad Yaqoob Akhtar, Nabilah Darnis, Deny Susanti Q Science (General) The incidence of epidemics due to drug resistant bacteria had posed public health concern. Thus, a novel antibacterial approach to synergize antibiotics in combination with essential oils of selected zingiberaceae plants was chosen in this study to aid in increasing the susceptibility of bacteria. The aim was to evaluate the in vitro interaction between the essential oils and five types of antibiotics against two gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) and two gram-negative bacteria (Esherichia coli and Pseudomonas aeruginosa). Essential oils from rhizomes of Curcuma mangga Val., Zingiber officinale var. rubrum Thelaide and Zingiber zerumbet (L.) Smith were extracted by hydrodistillation. The antibacterial testing employed was Minimum Inhibitory Concentration (MIC) using broth microdilution method. The interaction of essential oils and antibiotics was determined by Fractional Inhibitory Concentration (FIC) using chequerboard technique. Results revealed that essential oil of Curcuma mangga Val. synergized with erythromycin and tetracycline against B. cereus, and with streptomycin against E. coli. Essential oil of Z. officinale synergized with erythromycin and tetracycline against B. cereus and E. coli. Combination with penicillin also produced synergism against E.coli. Essential oil of Z. zerumbet when combined with tetracycline acted synergistically towards S. aureus, B. cereus and P. aeruginosa. Combination with penicillin acted synergistically towards B. cereus, E. coli and P. aeruginosa. When combined with streptomycin, it synergized against S. aureus and E. coli, while with ampicillin it synergized against B. cereus. From the results, all three essential oils exhibit antibacterial properties. Z. zerumbet has the most potent antibacterial property as it produced synergistic effects towards all four types of bacteria. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/40508/2/Slide%2C_Biomedical_Sympo_2014.pdf application/pdf en http://irep.iium.edu.my/40508/5/bacterial_strains.pdf Mohammad Yaqoob Akhtar, Nabilah and Darnis, Deny Susanti (2014) Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains. In: 5th Malaysian Symposium of Biomedical Science, 10th-11th May 2014, UKM Kuala Lumpur Campus, Kuala Lumpur.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Mohammad Yaqoob Akhtar, Nabilah Darnis, Deny Susanti Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains
description	The incidence of epidemics due to drug resistant bacteria had posed public health concern. Thus, a novel antibacterial approach to synergize antibiotics in combination with essential oils of selected zingiberaceae plants was chosen in this study to aid in increasing the susceptibility of bacteria. The aim was to evaluate the in vitro interaction between the essential oils and five types of antibiotics against two gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) and two gram-negative bacteria (Esherichia coli and Pseudomonas aeruginosa). Essential oils from rhizomes of Curcuma mangga Val., Zingiber officinale var. rubrum Thelaide and Zingiber zerumbet (L.) Smith were extracted by hydrodistillation. The antibacterial testing employed was Minimum Inhibitory Concentration (MIC) using broth microdilution method. The interaction of essential oils and antibiotics was determined by Fractional Inhibitory Concentration (FIC) using chequerboard technique. Results revealed that essential oil of Curcuma mangga Val. synergized with erythromycin and tetracycline against B. cereus, and with streptomycin against E. coli. Essential oil of Z. officinale synergized with erythromycin and tetracycline against B. cereus and E. coli. Combination with penicillin also produced synergism against E.coli. Essential oil of Z. zerumbet when combined with tetracycline acted synergistically towards S. aureus, B. cereus and P. aeruginosa. Combination with penicillin acted synergistically towards B. cereus, E. coli and P. aeruginosa. When combined with streptomycin, it synergized against S. aureus and E. coli, while with ampicillin it synergized against B. cereus. From the results, all three essential oils exhibit antibacterial properties. Z. zerumbet has the most potent antibacterial property as it produced synergistic effects towards all four types of bacteria.
format	Conference or Workshop Item
author	Mohammad Yaqoob Akhtar, Nabilah Darnis, Deny Susanti
author_facet	Mohammad Yaqoob Akhtar, Nabilah Darnis, Deny Susanti
author_sort	Mohammad Yaqoob Akhtar, Nabilah
title	Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains
title_short	Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains
title_full	Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains
title_fullStr	Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains
title_full_unstemmed	Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains
title_sort	synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains
publishDate	2014
url	http://irep.iium.edu.my/40508/ http://irep.iium.edu.my/40508/2/Slide%2C_Biomedical_Sympo_2014.pdf http://irep.iium.edu.my/40508/5/bacterial_strains.pdf
first_indexed	2023-09-18T20:58:09Z
last_indexed	2023-09-18T20:58:09Z
_version_	1777410442941956096

Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains

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